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Dissecting aortic aneurysm associated with congenital bicuspid aortic valve.
Abstract
Among 119 cases of fatal dissecting aneurysm of the aorta, exclusive of those iatrogenically caused or associated with arachnodactyly or aortic stenosis, there were observed 11 cases of congenital bicuspid aortic valve (9%). The ages ranged from 17 to 69 years, five of the patients being 29 years old or younger. Among the latter, three had coarctation of the aorta and one had Turner's syndrome without coarctation. In one of the older patients, aortic insufficiency was present. Hypertension was either established or inferred from cardiac weight in 73% of the cases. In each case, cystic medial necrosis of the aorta was present. Prolapse of valves other than the aortic was observed in 45% of the cases with bicuspid aortic valve. Compared to an estimated incidence of bicuspid aortic valve of about 1 to 2% in the population, the high incidence among subjects with dissecting aneurysm suggests a causative relationship between bicuspid aortic valve and aortic dissecting aneurysm.
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Citations
Cited by
Clinical significance of the bicuspid aortic valve
Ward, C. (2000) · Heart · doi:10.1136/heart.83.1.81 · Cited by 803
Bicuspid aortic valve is heritable
Cripe, L., Andelfinger, G., Martin, L. J., Shooner, K., & Benson, D. W. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.03.050 · Cited by 635
Hahn, R. T., Roman, M. J., Mogtadek, A. H., & Devereux, R. B. (1992) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(92)90479-7 · Cited by 406
Hypertension is a major risk factor for aortic root dilatation in women with Turner's syndrome
Elsheikh, M., Casadei, B., Conway, G. S., & Wass, J. A. H. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01154.x · Cited by 173
Metadata
- Authors
- Edwards, W. D., Leaf, D. S., & Edwards, J. E.
- Venue
- Circulation
- Published
- 1978-05
- Volume
- 57
- Issue
- 5
- Pages
- 1022-1025
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2040749098
- Cited by
- 266
- References
- 0
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Dissecting aortic aneurysm associated with congenital bicuspid aortic valve. https://app.cochat.ai/papers/10.1161/01.cir.57.5.1022
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- Edwards, W. D., Leaf, D. S., & Edwards, J. E. (1978). Dissecting aortic aneurysm associated with congenital bicuspid aortic valve. Circulation. https://doi.org/10.1161/01.cir.57.5.1022
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
