Atherogenesis: a postprandial phenomenon.
Open accessAbstract
The hypothesis that plasma chylomicrons in persons who ingest a cholesterol-rich diet are atherogenic is evaluated. Evidence is presented that in humans, and experimental animals, chylomicron remnants as well as low-density lipoproteins are taken up by arterial cells. In persons who do not have familial hyperlipoproteinemia, atherogenesis may occur during the postprandial period. Research directions that may contribute to the evaluation of chylomicron remnants as a risk factor for atherogenesis are discussed. Lipoprotein studies after administration of a test meal containing fat and cholesterol are urgently needed.
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The increase in the postprandial levels of remnant lipoprotein after meals can cause atherosclerosis.
“Zilversmit et al. proposed that the increase in the postprandial levels of remnant lipoprotein after meals can cause atherosclerosis. Considerable evidence has been accumulated thereafter, and this hypothesis has therefore been established as the disease concept238, 243–245).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [243]
Hyper-remnant-lipoproteinemia can explain part of the residual risk of all-cause mortality in patients with CAD.
“In addition, hyper-remnant-lipoproteinemia can explain part of the residual risk of allcause mortality in patients with CAD243).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [243]
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References 112 · Cited by 1,701
Research works printed but not linked: 2
- Smith EB, Smith RH: Early changes in aortic intima. In Atherosclerosis Reviews, vol 1, edited by Paoletti RP, Gotto AM Jr. New York, Raven Press, 1976, p 119
- Hazzard WR, Chait A, Brunzell J, Goldberg A, Applebaum D, Kushwaha RPS, Albers JJ: Type II hyperlipoproteinemia: pathophysiological implications of its paradoxical hypo- lipidemic response to estrogen. In Protides of the Biological Fluids, edited by Peeters H. New York, Pergamon Press, 1978, p 183
- Authors
- Zilversmit, D. B.
- Corresponding author
- Zilversmit, D B
- Venue
- Circulation
- Published
- 1979-09
- Volume
- 60
- Issue
- 3
- Pages
- 473-485
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1975936284
- Cited by
- 1,701
- References
- 112
- Citations by year
- 2026: 18 · 2025: 15 · 2024: 17 · 2023: 19 · 2022: 22 · 2021: 23 · 2020: 27 · 2019: 26 · 2018: 39 · 2017: 33 · 2016: 34 · 2015: 43 · 2014: 57 · 2013: 55 · 2012: 50
- FWCI
- 29.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Circulation
- Funders
- American Heart Association
- National Institutes of Health
- U.S. Public Health Service
- National Heart, Lung, and Blood Institute
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- atherogenesis, postprandial lipemia, chylomicron remnants, low-density lipoprotein, dietary cholesterol, familial hyperlipoproteinemia, atherosclerosis risk factors
- MeSH terms
- Animals, Haplorhini, Arteries, Arteriosclerosis, Cholesterol, Chylomicrons, Diet, Atherogenic, Dogs, Humans, Hypercholesterolemia, Intestinal Mucosa, Lipoproteins, Lipoproteins, LDL, Lipoproteins, VLDL, Liver, Rabbits, Swine, Rats
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