CoChat
Sign Up
Cited by 175Acute Myocardial Infarction ResearchCardiac Ischemia and ReperfusionAcute Ischemic Stroke Management

The DOI matches its Crossref record.

Reduction of CK and CK-MB indexes of infarct size by intravenous nitroglycerin.

Bussmann, W D, Passek, D, Seidel, W, Kaltenbach, M·1981·Circulation
DOI 10.1161/01.cir.63.3.615
Open this paper in CoChat — free account

Abstract

The effect of i.v. nitroglycerin administration on indexes of infarct size was examined in 31 patients with acute myocardial infarction. Serial creatine kinase (CK) and CK-MB isoenzyme determinations were used to calculate infarct size. Twenty-nine patients served as controls. Two subgroups of the study group were formed to evaluate differences between early and late intervention. In the first group (n = 22), continuous infusion of nitroglycerin over 48 hours was initiated within 8 hours (mean 4.5 hours) after the onset of symptoms. Peak CK activity for the nitroglycerin-treated patients (n = 9) in this subgroup was 544 U/1 vs 871 U/1 for the controls (n = 13) (p less than 0.05). The rate of CK release was reduced from 79 to 33 U/1.hr (58%), as was total CK and CK-MB release (p less than 0.02). Calculated infarct size was 69 gEq in the controls and 48 gEq in patients receiving nitroglycerin (CK-MB: 69 vs 43 gEq, p less than 0.05). In the late intervention subgroup, nitroglycerin therapy was begun more than 8 hours (mean 12.8 hours) after the onset of symptoms. Here, too, use of the agent was associated with lower peak CK and CK-MB levels as well as a reduction in calculated infarct size (p less than 0.05). Hemodynamic measurements, recorded every 4 hours, showed that nitroglycerin also reduced left ventricular filling pressure significantly and cardiac output increased. Blood pressure fell slightly, and systemic vascular resistance declined. The results indicate that i.v. nitroglycerin reduces CK and CK-MB release and thus calculated infarct size in both early and late intervention.

Overview

Integrity signals

Registry

Crossref · 10.1161/01.cir.63.3.615

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Still being checked.

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Bussmann, W. D., Passek, D., Seidel, W., & Kaltenbach, M.
Affiliations
École Polytechnique (FR)
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1981-03
Volume
63
Issue
3
Pages
615-622
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.63.3.615
OpenAlex
W2074359473
Cited by
175
References
0
Citations by year
2022: 2 · 2021: 1 · 2015: 2 · 2013: 2 · 2012: 1
FWCI
13.82
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
  • Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Keywords
nitroglycerin, acute myocardial infarction, infarct size, creatine kinase, CK-MB, myocardial enzyme release, early versus late intervention, left ventricular filling pressure, cardiac output, systemic vascular resistance
MeSH terms
Adult, Aged, Blood Pressure, Cardiac Output, Creatine Kinase, Nitroglycerin, Hemodynamics, Humans, Injections, Intravenous, Isoenzymes, Middle Aged, Myocardial Infarction, Time Factors, Vascular Resistance

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review