The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Borderline hypertension and obesity: two prehypertensive states with elevated cardiac output
Open accessAbstract
Systemic, renal and splanchnic hemodynamics, intravascular volume, circulating catecholamine levels and plasma renin activity were compared in 39 patients with borderline hypertension and 28 normotensive subjects, who were less than 5% (n = 42, lean patients) or more than 40% overweight (n = 25, obese patients). Lean borderline hypertensive patients had greater cardiac output (p less than 0.05), heart rate (p less than 0.01) and renal blood flow (p less than 0.05); cardiopulmonary redistribution of intravascular volume (p less than 0.05); and higher circulating norepinephrine levels (p less than 0.05). Obese normotensive subjects also showed an increased cardiac output (p less than 0.005), stroke volume (p less than 0.01), left ventricular stroke work (p less than 0.05), and renal blood flow (p less than 0.05) (but not respective indexes), but intravascular volume was expanded (p less than 0.05) without redistribution and circulating catecholamine levels were normal. Obese borderline hypertensive patients had hemodynamic characteristics similar to those of obese normotensive subjects except for an increased peripheral resistance (p less than 0.05). The data indicate that although both populations have an increased cardiac output, the lean borderline hypertensive patients have signs of enhanced adrenergic activity as evidenced by higher circulating catecholamine levels and heart rate with blood volume translocation to the cardiopulmonary circulation. In contrast, the obese subjects (whether normotensive or borderline hypertensive), who also have increased cardiac output, seem to have normal adrenergic activity and an expanded intravascular volume without cardiopulmonary redistribution.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Typically, obese patients have a higher cardiac output but a lower level of total peripheral resistance at any given level of arterial pressure (14,15).”
From Obesity and Cardiovascular Disease (2009) · cites this paper as [15]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine
Peuler, J. D., & Johnson, G. A. (1977) · Life Sciences · doi:10.1016/0024-3205(77)90070-4 · Cited by 1,899
Statistical Methods in Medical Research
Lachenbruch, P. A., & Armitage, P. (1972) · Technometrics · doi:10.2307/1266938 · Cited by 1,728
DIVITIIS, O. D., Fazio, S., Petitto, M., Maddalena, G., Contaldo, F., & Mancini, M. (1981) · Circulation · doi:10.1161/01.cir.64.3.477 · Cited by 394
Kannel, W. B. (1976) · BMJ · doi:10.1136/bmj.2.6046.1255-a · Cited by 394
Freis, E. D. (1960) · Physiological Reviews · doi:10.1152/physrev.1960.40.1.27 · Cited by 374
Age-Adjusted Plasma Norepinephrine Levels Are Similar in Normotensive and Hypertensive Subjects
Lake, C. R., Ziegler, M. G., Coleman, M. D., & Kopin, I. J. (1977) · New England Journal of Medicine · doi:10.1056/nejm197701272960408 · Cited by 313
Autonomic nervous cardiovascular regulation in borderline hypertension
Julius, S., & Esler, M. (1975) · The American Journal of Cardiology · doi:10.1016/0002-9149(75)90170-8 · Cited by 268
Prediction of the normal blood volume. Relation of blood volume to body habitus.
Feldschuh, J., & Enson, Y. (1977) · Circulation · doi:10.1161/01.cir.56.4.605 · Cited by 262
Physiological comparison of labile and essential hypertension.
Ed, F., Kozul, V. J., Rc, T., & Dustan, H. P. (1970) · PubMed · Cited by 200
Systemic and regional hemodynamics in low, normal and high cardiac output borderline hypertension.
Messerli, F. H., de Carvalho, J. G., Christie, B., & Frohlich, E. D. (1978) · Circulation · doi:10.1161/01.cir.58.3.441 · Cited by 175
Self-citation
Flagged first, then by citations
Research works printed but not linked: 3
- Julius S: Borderline hypertension: epidemiologic and clinical manifestations. In Hypertension: Physiopathology and Treatment, edited by Genest J, Koiw E, Kuchel 0. New York, McGraw-Hill, 1977, p 630
- Frohlich ED: Hemodynamics in hypertension. In Hypertension: Physiopathology and Treatment, edited by Genest J, Koiw E, Kuchel 0. New York, McGraw-Hill, 1977, p 15
- New Weight Standards for Men and Women. Statistical Bulletin, Metropolitan Life Insurance Company 40: 1, 1959
Cited by
Sorted by citations
Kopelman, P. G. (2000) · Nature · doi:10.1038/35007508 · Cited by 4,795
Obesity and Cardiovascular Disease
Lavie, C. J., Milani, R. V., & Ventura, H. O. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.12.068 · Cited by 2,326
Self-citationObesity and the risk of new-onset atrial fibrillation
Wang, T. J. (2004) · JAMA · doi:10.1001/jama.292.20.2471 · Cited by 1,427
Impact of Obesity on Plasma Natriuretic Peptide Levels
Wang, T. J., Larson, M. G., Levy, D., Benjamin, E. J., Leip, E. P., Wilson, P. W. F., & Vasan, R. S. (2004) · Circulation · doi:10.1161/01.cir.0000112582.16683.ea · Cited by 1,022
Obesity cardiomyopathy: pathophysiology and evolution of the clinical syndrome
Alpert, M. A. (2001) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200104000-00003 · Cited by 795
Metadata
- Authors
- Messerli, F. H., Ventura, H. O., Reisin, E., Dreslinski, G. R., Dunn, F. G., MacPhee, A. A., & Frohlich, E. D.
- Venue
- Circulation
- Published
- 1982-07
- Volume
- 66
- Issue
- 1
- Pages
- 55-60
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2033757938
- Cited by
- 201
- References
- 20
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 9 · 2017: 4 · 2016: 8 · 2015: 6 · 2014: 4 · 2013: 8 · 2012: 4
- FWCI
- 6.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-22506)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- borderline hypertension, obesity, prehypertension, cardiac output, hemodynamics, renal blood flow, catecholamines, norepinephrine, plasma renin activity, systemic vascular resistance, heart rate, stroke volume, left ventricular stroke work
- MeSH terms
- Adult, Blood Volume, Body Weight, Cardiac Output, Female, Heart Rate, Humans, Hypertension, Male, Middle Aged, Obesity, Renal Circulation, Stroke Volume
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
