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Cited by 381

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Reduction of coronary reserve: a mechanism for angina pectoris in patients with arterial hypertension and normal coronary arteries.

Opherk, D, Mall, G, Zebe, H, Schwarz, F, Weihe, E, Manthey, J, Kübler, W·1984·Circulation

Abstract

The pathogenesis of angina pectoris in patients with left ventricular hypertrophy secondary to arterial hypertension and with normal coronary arteries remains uncertain. We measured coronary blood flow (argon method) in 12 control subjects and in 16 patients with arterial hypertension at rest and after intravenous administration of dipyridamole (0.5 mg/kg). In the patients with arterial hypertension, coronary blood flow response to dipyridamole was markedly reduced (p less than .001 as compared with control values). During coronary vasodilation there was a linear correlation between coronary resistance and left ventricular end-diastolic pressure (r = .67, p less than .001). Left ventricular catheter biopsy specimens did not reveal alterations in myocardial microvasculature. These findings suggest that reduction of coronary reserve may be an important contributor to the pathogenesis of angina pectoris in these patients.

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Metadata

Authors
Opherk, D., Mall, G., Zebe, H., Schwarz, F., Weihe, E., Manthey, J., & Kübler, W.
Venue
Circulation
Published
1984-01
Volume
69
Issue
1
Pages
1-7
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W2052333785
Cited by
381
References
0
FWCI
13.61
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Reduction of coronary reserve: a mechanism for angina pectoris in patients with arterial hypertension and normal coronary arteries. https://app.cochat.ai/papers/10.1161/01.cir.69.1.1
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Opherk, D., Mall, G., Zebe, H., Schwarz, F., Weihe, E., Manthey, J., & Kübler, W. (1984). Reduction of coronary reserve: a mechanism for angina pectoris in patients with arterial hypertension and normal coronary arteries. Circulation. https://doi.org/10.1161/01.cir.69.1.1

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.