HLA-DR/DQ antigens and reactivity to B cell alloantigen D8/17 in Indian patients with rheumatic heart disease.
Abstract
D8/17, a B cell alloantigen, and its occurrence with DR/DQ antigens was examined in 54 patients with rheumatic heart disease and matched North Indian controls. Thirty-four patients (62.9%) carried D8/17 as compared with a frequency of 12.5% in controls (chi 2 by Yates', 18.75; p less than 0.0001). A marginally increased frequency of human leukocyte antigen (HLA)-DR3 (44.2% vs. 28.8%) and a significantly reduced frequency of HLA-DR2 (21.1% vs. 46.6%; p less than 0.005) was observed in patients as compared with controls. However, the most significant positive association was observed with HLA-DQw2 (63.4% in patients and 31.5% in controls; chi 2 by Yates', 9.85; p less than 0.005). The DQw2 association was significant only in the D8/17-positive patients. These observations suggest that the disease susceptibility gene in rheumatic heart disease may be nearer to the HLA-DQ locus than to the HLA-DR.
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A high frequency of in vitro elevated D8/17 binding to B lymphocytes has been found as a susceptibility marker for developing ARF more than PSRA.
“A high frequency of in vitro elevated D8/17 binding to B lymphocytes has been found as a susceptibility marker for developing ARF more than PSRA [7, 8, 24].”
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Jansen, T. L. T. A. (2009) · International Journal of Rheumatology · doi:10.1155/2009/286951
“A high frequency of in vitro elevated D8/17 binding to B lymphocytes has been found as a susceptibility marker for developing ARF more than PSRA [7, 8, 24].”
Background
- Authors
- Taneja, V, Mehra, N. K., Reddy, K. S., Narula, J., Tandon, R., Vaidya, M. C., & Bhatia, M. L.
- Affiliations
- All India Institute of Medical Sciences (IN)
- Venue
- Circulation
- Published
- 1989-08
- Volume
- 80
- Issue
- 2
- Pages
- 335-340
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2078296260
- Cited by
- 55
- References
- 0
- Citations by year
- 2023: 1 · 2020: 1 · 2015: 2 · 2013: 1 · 2012: 2
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Circulation
- Funders
- Indian Council of Medical Research
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Streptococcal Infections and Treatments
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- rheumatic heart disease, HLA-DR, HLA-DQ, HLA-DQ2, HLA-DR3, HLA-DR2, susceptibility genes, genetic association, Indian patients
- MeSH terms
- Antigens, Differentiation, B-Lymphocyte, Disease Susceptibility, Female, Gene Frequency, Histocompatibility Testing, HLA-DQ Antigens, HLA-DR Antigens, Humans, India, Isoantigens, Male, Phenotype, Rheumatic Heart Disease
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