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Cited by 386

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Antiplatelet treatment with ticlopidine in unstable angina. A controlled multicenter clinical trial. The Studio della Ticlopidina nell'Angina Instabile Group.

Open access
Balsano, F, Rizzon, P, Violi, F, Scrutinio, D, Cimminiello, C, Aguglia, F, Pasotti, C, Rudelli, G·1990·Circulation
DOI 10.1161/01.cir.82.1.17
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Abstract

We conducted a controlled multicenter trial with central randomization and evaluation of events under blind conditions involving 652 patients with unstable angina. Patients were treated either with conventional therapy alone (group C) (n = 338) or with conventional therapy combined with an inhibitor of platelet aggregation, ticlopidine 250 mg b.i.d. (group C + T) (n = 314). Patients were assigned randomly within 48 hours of admission and followed up for 6 months. With the "intention-to-treat" approach, the primary end points, vascular death and nonfatal myocardial infarction, were observed in 13.6% of the patients in group C and in 7.3% of the patients in group C + T, which is a reduction in risk of 46.3% (p = 0.009). Vascular mortality was 4.7% in patients in group C and 2.5% in patients in group C + T, which is a reduction in risk of 46.8% (p = 0.139). The risk of nonfatal myocardial infarction was reduced by 46.1% (p = 0.039), with a frequency of 8.9% in patients in group C and 4.8% in patients in group C + T. New Q wave myocardial infarction occurred with a frequency of 6.8% in patients in group C and 3.8% in patients in group C + T, which is a reduction in risk of 44.1% (p = 0.091). Fatal and nonfatal myocardial infarction was 10.9% in patients in group C and 5.1% in patients in group C + T, which is a reduction in risk of 53.2% (p = 0.006). These findings confirm the importance of platelets in the pathogenesis of unstable angina and the usefulness of antiplatelet treatment for the prevention of cardiovascular events.

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Metadata

Authors
Balsano, F., Rizzon, P., Violi, F., Scrutinio, D., Cimminiello, C., Aguglia, F., Pasotti, C., & Rudelli, G.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1990-07
Volume
82
Issue
1
Pages
17-26
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.82.1.17
OpenAlex
W1990963444
Cited by
386
References
27
FWCI
16.88
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Antiplatelet treatment with ticlopidine in unstable angina. A controlled multicenter clinical trial. The Studio della Ticlopidina nell'Angina Instabile Group. https://app.cochat.ai/papers/10.1161/01.cir.82.1.17
The paper
Balsano, F., Rizzon, P., Violi, F., Scrutinio, D., Cimminiello, C., Aguglia, F., Pasotti, C., & Rudelli, G. (1990). Antiplatelet treatment with ticlopidine in unstable angina. A controlled multicenter clinical trial. The Studio della Ticlopidina nell'Angina Instabile Group. Circulation. https://doi.org/10.1161/01.cir.82.1.17

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.