Exercise training confers anticipatory protection from sudden death during acute myocardial ischemia.
Abstract
Seven conscious dogs documented to be at high risk by the occurrence of ventricular fibrillation (VF) during acute myocardial ischemia were randomly assigned to 6 weeks of either daily exercise training or cage rest followed by exercise training. After 6 weeks of daily treadmill training, heart rate variability, a marker of vagal tone, increased by 74% (P < .001); baroreflex sensitivity, a marker of the capability to reflexly augment vagal activity, increased by 69% (P < .01); the repetitive extrasystole threshold, a marker of ventricular electrical stability, increased by 44% (P < .05). After exercise training, the incidence of ventricular fibrillation during acute myocardial ischemia decreased by 100%, as all animals survived. Neither passage of time nor heart rate level during ischemia contributed to the outcome. The most likely mechanism to explain the striking change in risk status is the shift in autonomic balance characterized by increased cardiac vagal activity, which was previously shown to have an antifibrillatory effect. These results suggest that exercise training in healthy individuals may decrease their likelihood of developing lethal arrhythmias during acute myocardial ischemia.
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Habitual vigorous exertion increases basal vagal tone, resulting in increased cardiac electrical stability and in protection against ventricular fibrillation.
“However, habitual vigorous exertion increases basal vagal tone, resulting in increased cardiac electrical stability and in protection against ventricular fibrillation.27”
From Triggering of Sudden Death from Cardiac Causes by Vigorous Exertion (2000) · cites this paper as [27]
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References 20 · Cited by 299
- Authors
- Hull, S. S., Vanoli, E., Adamson, P. B., Verrier, R. L., Foreman, R. D., & Schwartz, P. J.
- Affiliations
- University of Oklahoma Health Sciences Center (US)
- Venue
- Circulation
- Published
- 1994-02
- Volume
- 89
- Issue
- 2
- Pages
- 548-552
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2083274334
- Cited by
- 299
- References
- 20
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 6 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 10 · 2014: 9 · 2013: 7 · 2012: 13
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl042321-03)
- National Heart, Lung, and Blood Institute (HL-42321-03)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- exercise training, sudden cardiac death, acute myocardial ischemia, ventricular fibrillation, heart rate variability, vagal tone, baroreflex sensitivity, sympathovagal balance, cardiac vagal activity, arrhythmia prevention, treadmill training
- MeSH terms
- Acute Disease, Animals, Death, Sudden, Dogs, Heart Rate, Physical Conditioning, Animal, Ventricular Fibrillation, Survival Analysis, Myocardial Ischemia
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