The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Accumulation of activated mast cells in the shoulder region of human coronary atheroma, the predilection site of atheromatous rupture.
Abstract
BACKGROUND: Rupture in the shoulder region of a coronary atheroma is considered to be a sequel to local extracellular matrix degradation in this highly vulnerable site. Such degradation could be triggered by mast cells, which are filled with neutral proteases and are present in coronary atheromas. However, the distribution and phenotype of mast cells within coronary atheromas have not been studied. METHODS AND RESULTS: Specimens of normal and atherosclerotic human coronary intima from 32 autopsy cases with ages ranging from 13 to 67 years were stained with monoclonal antibodies against the two major proteases of mast cells, tryptase and chymase. Of the tryptase-containing mast cells, a variable proportion (average, 40%; range, 0% to 100%) also contained chymase. In the normal coronary intimas, mast cells amounted to 0.1% of all nucleated cells. In the fatty streaks, this proportion was higher by 9-fold, and in the cap, core, and shoulder regions of atheromas by 5-, 5-, and 10-fold, respectively. Electron and light microscopic studies of mast cells in the shoulder region of atheromas revealed degranulation of mast cells, a sign of their activation, and moreover, that the proportion of activated mast cells was much higher (85%) in this region than in the normal intima (18%). CONCLUSIONS: The far higher proportion (50-fold) of activated mast cells in the shoulder region of atheromas supports the hypothesis that mast cells, a cell type capable of triggering matrix degradation, actively participate in the destabilization and ensuing rupture of coronary atheromas and thus may trigger an acute coronary event.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,630
Metalloproteinases and their inhibitors in matrix remodeling
Matrisian, L. M. (1990) · Trends in Genetics · doi:10.1016/0168-9525(90)90126-q · Cited by 1,605
Zsebo, K. M., Williams, D. A., Geissler, E. N., Broudy, V. C., Martin, F. H., Atkins, H. L., Hsu, R.-Y., Birkett, N. C., Okino, K. H., Murdock, D. C., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90302-u · Cited by 1,388
RICHARDSON, P. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90953-7 · Cited by 1,258
Two types of human mast cells that have distinct neutral protease compositions.
Irani, A. A., Schechter, N. M., Craig, S. S., DeBlois, G., & Schwartz, L. B. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4464 · Cited by 1,005
Anderson, D. M., Lyman, S. D., Baird, A., Wignall, J. M., Eisenman, J., Rauch, C., March, C. J., Boswell, H. S., Gimpel, S. D., Cosman, D., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90304-w · Cited by 831
Gown, A. M., Tsukada, T., & Ross, R. (1986) · PubMed · Cited by 676
Involvement of the immune system in human atherogenesis: current knowledge and unanswered questions.
Libby, P., & Hansson, G. K. (1991) · PubMed · Cited by 663
Stary, H. C., Blankenhorn, D. H., Chandler, A. B., Glagov, S., Insull, W., Richardson, M., Rosenfeld, M. E., Schaffer, S. A., Schwartz, C. J., & Wagner, W. D. (1992) · Circulation · doi:10.1161/01.cir.85.1.391 · Cited by 627
Galli, S. J. (1990) · Pathology Reviews • 1990 · doi:10.1007/978-1-4612-0485-5_5 · Cited by 615
Cited by
Falk, E., Shah, P. K., & Fuster, V. (1995) · Circulation · doi:10.1161/01.cir.92.3.657 · Cited by 3,536
INFLAMMATION AND ATHEROSCLEROSIS
Hansson, G. K., Robertson, A.-K. L., & Söderberg-Nauclér, C. (2006) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100100 · Cited by 1,046
Taipale, J., Lohi, J., Saarinen, J., Kovanen, P. T., & Keski-Oja, J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.9.4689 · Cited by 398
Self-citationLaine, P., Kaartinen, M., Penttilä, A., Panula, P., Paavonen, T., & Kovanen, P. T. (1999) · Circulation · doi:10.1161/01.cir.99.3.361 · Cited by 342
Self-citationIntracellular versus extracellular granzyme B in immunity and disease: challenging the dogma
Boivin, W. A., Cooper, D. M., Hiebert, P. R., & Granville, D. J. (2009) · Laboratory Investigation · doi:10.1038/labinvest.2009.91 · Cited by 314
Metadata
- Authors
- Kaartinen, M., Penttilä, A., & Kovanen, P. T.
- Venue
- Circulation
- Published
- 1994-10
- Volume
- 90
- Issue
- 4
- Pages
- 1669-1678
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2084554873
- Cited by
- 444
- References
- 32
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Accumulation of activated mast cells in the shoulder region of human coronary atheroma, the predilection site of atheromatous rupture. https://app.cochat.ai/papers/10.1161/01.cir.90.4.1669
- The paper
- Kaartinen, M., Penttilä, A., & Kovanen, P. T. (1994). Accumulation of activated mast cells in the shoulder region of human coronary atheroma, the predilection site of atheromatous rupture. Circulation. https://doi.org/10.1161/01.cir.90.4.1669
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
