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Lewis A. Conner Memorial Lecture. Mechanisms leading to myocardial infarction: insights from studies of vascular biology.
Abstract
Myocardial infarction is the most frequent cause of mortality in the United States as well as in most western countries. In this review, the processes leading to myocardial infarction are described based on the most recent studies of vascular biology; in addition, evolving strategies for prevention are outlined. The following was specifically discussed. (1) Five phases of the progression of coronary atherosclerosis (phases 1 to 5) and eight morphologically different lesions (types I, II, III, IV, Va, Vb, Vc, and VI) in the various phases are defined. (2) The present understanding of the pathogenesis of each of the phases of progression and of the various lesion types preceding myocardial infarction is described; particular emphasis is placed on the physical, structural, cellular, and chemical characteristics of the "vulnerable or unstable plaques" prone to disruption (types IV and Va lesions). (3) The fate of plaque disruption (type VI lesion) in the genesis of the various coronary syndromes and especially acute myocardial infarction is defined; particular emphasis is placed on the combination of plaque disruption and a high thrombogenic risk profile--local factors (ie, degree of plaque disruption, exposure of lipid-macrophage-rich plaque, etc) and systemic factors (ie, catecholamines, RAS, fibrinogen, etc)--in the genesis of myocardial infarction. (4) Strategies of regression or stabilization of "vulnerable or unstable plaques" for prevention of myocardial infarction are presented within the context of recent favorable experience with risk factor modification and lipid-modifying angiographic trials, beta-blockade and angiotensin-converting enzyme inhibition, antithrombotic strategies, and the possible role of estrogens. The recent past has been very fruitful in yielding a better understanding of the processes leading to myocardial infarction, and the near future appears very promising in terms of preventing the number 1 killer in the western world.
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“However, therapies for lowering the concentration of homocysteine through vitamin supplementation did not result in the suppression of events292, 293).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [293]
Citations
Cites
(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064
A novel potent vasoconstrictor peptide produced by vascular endothelial cells
Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y. I., Kobayashi, M., Mitsui, Y., Yazaki, Y., Goto, K., & Masaki, T. (1988) · Nature · doi:10.1038/332411a0 · Cited by 10,716
The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618
The SOLVD Investigators* (1991) · New England Journal of Medicine · doi:10.1056/nejm199108013250501 · Cited by 8,029
Pfeffer, M. A., Braunwald, E., Moyé, L. A., Basta, L., Brown, E. J., Cuddy, T. E., Davis, B. R., Geltman, E. M., Goldman, S., Flaker, G. C., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271001 · Cited by 5,911
Vascular endothelial cells synthesize nitric oxide from L-arginine
Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,786
The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes
Epstein, F. H., Fuster, V., Badimón, L., Badimón, L., & Chesebro, J. H. (1992) · New England Journal of Medicine · doi:10.1056/nejm199201303260506 · Cited by 3,792
Self-citation(1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271003 · Cited by 3,725
Moncada, S., Gryglewski, R. J., Bunting, S., & Vane, J. R. (1976) · Nature · doi:10.1038/263663a0 · Cited by 3,593
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Items 701–800 of 848
Introduction to Invasive Assessment of the Coronary Circulation
Pijls, N. H. J., & Bruyne, B. D. (2000) · Developments in cardiovascular medicine · doi:10.1007/978-94-015-9564-3_3 · Cited by 1
Stress drives myelopoiesis to impair atherosclerosis resolutionPreprint
Fisher, E. A. A., Tufanlı, Ö., Scolaro, B., Civieri, G., Schlamp, F., Delbare, S., Weinstock, A., Cathomas, F., Pena, S., Berrío, A. T., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-6727599/v1 · Cited by 1
Molecular Analysis of Vascular Development and Disorders
Carmeliet, P., & Collen, D. (1999) · Developments in cardiovascular medicine · doi:10.1007/978-94-015-9321-2_18 · Cited by 1
Antithrombotic Therapy in Unstable Angina and Non-Q-Wave Myocardial Infarction
Cohen, M. C., & Blaber, R. (1999) · Contemporary cardiology · doi:10.1007/978-1-59259-731-4_16 · Cited by 1
Pathophysiological Basis of the Acute Coronary Syndromes
Huber, K., & Kaindl, F. (2000) · Springer eBooks · doi:10.1007/978-1-4612-1190-7_12 · Cited by 1
Novel Antithrombotic Strategies
Bitar, J. N., Dabaghi, S. F., Sekili, S., & Kleiman, N. S. (1998) · Developments in cardiovascular medicine · doi:10.1007/978-1-4615-5715-9_7
Mast cells and endothelial erosion: Implications for human atherothrombotic disease
Mäyränpää, M. I. (2007) · Työväentutkimus Vuosikirja
Disease state and treatment of Acute Coronary Syndrome.
光宏, 横. (1998) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.87.548
Rees, M. R., Zijlstra, F., Reiber, J. H. C., Tuinenburg, J. C., Koning, G., Janssen, J. P., Rareş, A., Lansky, A. J., Goedhart, B., Ligthart, J. M. R., et al. (2009) · Medical radiology · doi:10.1007/978-3-540-32984-8_2
Role of Hyperhomocysteinemia in Atherosclerosis
Colgan, S. M., Jacobsen, D. W., & Austin, R. C. (2006) · Springer eBooks · doi:10.1007/0-387-36279-3_16
Aterosclerosis y trombosis en la diabetes mellitusNuevos aspectos de la fisiopatología
Colwell, J. A., Lyons, T. J., Klein, R. L., Lopes-Virella, M. E., & Jokl, R. (2008) · Elsevier eBooks · doi:10.1016/b978-84-8086-367-4.50005-9
Molecular Controls of Smooth Muscle Hypertrophy and Hyperplasia
Ross, R. (1995) · Elsevier eBooks · doi:10.1016/b978-012632310-8/50011-5
Petersen, K. L. (2007) · D-Scholarship@Pitt (University of Pittsburgh)
Gibson, S. C. (2008) · Enlighten: Theses (The University of Glasgow)
Brogren, H. (2008) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Nuclear Cardiology 2: Myocardial Perfusion, Metabolism, Infarction, and Receptor Imaging
Macháč, J. (2014) · Springer eBooks · doi:10.1007/978-3-319-06112-2_15
Antiinflammatorische Therapie mit Statinen? C-reaktives Protein und Atherosklerose
Auer, J., Berent, R., Eber, B., Laßnig, E., Maurer, E., & Weber, T. (2002) · Journal für Kardiologie (Krause & Pachernegg GmbH)
Willerson, J. T. (1996) · Developments in cardiovascular medicine · doi:10.1007/978-94-009-1577-0_11
Acute Coronary Syndromes and Myocardial Infarction
Hobson, A. R., & Curzen, N. P. (2010) · doi:10.1002/9781444314502.ch13
von Schulthess, G. K., Bongartz, G. M., von Smekal, A., Layer, G., KAICK, G. V., & Heywang-Köbrunner, S. H. (1997) · Springer eBooks · doi:10.1007/978-3-642-97962-0_5
CHRONIC STRESS, INFLAMMATION, AND PROGRESSION OF CAROTID ARTERY ATHEROSCLEROSIS: A MEDIATION MODEL
Janicki, D. L. (2006) · D-Scholarship@Pitt (University of Pittsburgh)
Introduction to Invasive Assessment of the Coronary Circulation
Pijls, N. H. J., & Bruyne, B. D. (1997) · Developments in cardiovascular medicine · doi:10.1007/978-94-015-8834-8_3
Hiperhomocisteinemia, polimorfismos genéticos y síndrome coronario agudo
Pinilla, G., & Manuel, J. (2011) · Dialnet (Universidad de la Rioja)
COURAGE y el nuevo paradigma de la enfermedad coronaria
Sandoya, E. (2008) · Redalyc (Universidad Autónoma del Estado de México)
Winther, K., Husted, S., Nielsen, H. K., & Nielsen, J. D. (1996) · Developments in cardiovascular medicine · doi:10.1007/978-94-009-1577-0_10
Public health aspects of serum cholesterol
Houterman, S. (2001) · RePub (Erasmus University Rotterdam)
La aterosclerosis como desencadenante de la patología cardiovascular.
Gutiérrez‐Abejón, E. (2010) · Hispana
What pathologists want from vascular ultrasound
Pasterkamp, G., & Falk, E. (2003) · Springer eBooks · doi:10.1007/978-4-431-67871-7_2
Krist, L. (2009) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-13931
Gonçalves, I. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7425-8_16
The Vascular Biology of Atherosclerosis
Jones, H. P., & Carter, R. (2005) · CRC Press eBooks · doi:10.1201/9781420038422.ch5
The role of thrombosis in acute coronary heart disease
Fernández‐Ortíz, A., & Fuster, V. (1996) · Developments in cardiovascular medicine · doi:10.1007/978-94-009-1577-0_13
Self-citationPhysiopathologie et étiopathogénie de l'infarctus du myocarde
Benamer, H., Boudjelal, S., Chachoua, K., & Akoudad, H. (2011) · EMC - Cardiologie · doi:10.1016/s1166-4568(11)53117-1
Cholestérolémie et pathologie: le point
Schlienger, J.-L., Goichot, B., & Pradignac, A. (1998) · La Revue de Médecine Interne · doi:10.1016/s0248-8663(97)80717-5
Dragoni, F. (2013) · International Journal of Cardiovascular Research · doi:10.4172/2324-8602.1000165
Prehospital Thrombolysis in Acute Myocardial Infarction Salvages Myocardium
Gotsman, M. S., Weiss, A., Rozenman, Y., Lotan, C., Zahger, D., & Mosseri, M. (1997) · Journal of Interventional Cardiology · doi:10.1111/j.1540-8183.1997.tb00049.x
Síndrome coronario agudo sin elevación del segmento ST en medicina de urgencias
Bonnefoy‐Cudraz, E., & Sanchez, I. (2006) · EMC - Anestesia-Reanimación · doi:10.1016/s1280-4703(06)45314-7
Thompson, K. G., James, K. A. C., Arthur, D. G., Maccoll, A. J., Broadhurst, R. B., Booth, C. L., Butler, R. C., Moughan, P. J., & Lubbe, W. F. (2003) · Nutrition Research · doi:10.1016/s0271-5317(03)00032-0
Clinical Evaluation of Coronary Lesion Characteristics in Acute Myocardial Infarction
Tomoda, H., & Aoki, N. (2003) · Angiology · doi:10.1177/000331970305400303
The influence of antibiotics and statins on inflammation in coronary disease
Stojanović, R., Vasiljević, Z., Prostran, M. S., Radovanović, M., Stefanović, B., Radovanović, N., Janković, J., Lakićević, M., Mitrovic, P. M., Lasica, R., et al. (2005) · Vojnosanitetski pregled · doi:10.2298/vsp0509661s
David, C., Provost, B., & Bezon, E. (2014) · Interbloc · doi:10.1016/j.bloc.2014.01.006
Platelet-Endothelium Interaction-A key Corinection to Atherothrombotic Events
Kishi, Y., Sakita, S., Ohta, S., Watanabe, R., Watanabe, T., Kobayashi, Y., Maruyama, Y., Ashikaga, T., & Numano, F. (1998) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat1994.4.144
Restenosis: The Clinical Problem
Simon, A. D., Warshofsky, M. K., & Schwartz, A. J. (1999) · Perspectives in antisense science · doi:10.1007/978-1-4615-5183-6_1
Potential Role of Platelet Glycoprotein IIb/IIIa Antagonists in Cerebrovascular Disorders
Mousa, S. A. (2000) · CNS Drugs · doi:10.2165/00023210-200013030-00001
Evolving Understanding of Coronary Thrombosis and New Insights into Therapeutic Strategies
Fuster, V. (1998) · Medical science symposia series · doi:10.1007/978-94-011-5022-4_6
Self-citationA 39-Year-Old Woman With Hypercholesterolemia
Mittleman, M. A. (2006) · JAMA · doi:10.1001/jama.296.3.319
EDITORIAL:CYTOKINES AND CARDIOVASCULAR DISEASE
Toschi, V. (1999) · Pharmacological Research · doi:10.1006/phrs.1999.0500
Radtke, S., & Wolf, R. (2001) · Zeitschrift für Kardiologie · doi:10.1007/s003920170165
Neues zur Therapie der instabilen Angina pectoris
Neumann, F., & Schömig, A. (1999) · Der Anaesthesist · doi:10.1007/s001010050776
Aortic plaque rupture in the setting of acute lower limb ischemia
O’Donnell, D., Moloney, M. A., Killeen, R. P., Sheehan, S. J., & Brophy, D. P. (2010) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2009.12.028
Atherosclerosis Progression and Vascular Adaptation
Libby, P. (1997) · Journal of Vascular and Interventional Radiology · doi:10.1016/s1051-0443(97)70639-0
pH-Dependent nanostructure based on isoquinoline-cyclodextrin conjugate for thrombosis therapy
Li, L., Zhao, M., Li, W., Wang, Y., Liu, C., Zhang, Z., Su, S., & Peng, S. (2012) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2011.12.008
Electron-beam computed tomography for detecting coronary artery disease and cardiac events
Basu, A. G., & Verani, M. S. (2000) · Journal of Nuclear Cardiology · doi:10.1067/mnc.2000.111086
Pathophysiology of Unstable Angina
Roqué, M., Badimón, L., & Badimón, J. J. (1999) · Thrombosis Research · doi:10.1016/s0049-3848(99)00068-7
Long-term arterial patency after coronary reperfusion
Branzi, A., Melandri, G., Semprini, F., Descovich, B., Nanni, S., & Cervi, V. (1999) · International Journal of Cardiology · doi:10.1016/s0167-5273(98)00288-5
A Circadian Perspective on Myocardial Ischaemia
Gnecchi‐Ruscone, T., Montano, N., Guzzetti, S., & Pagani, M. (1995) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/174182679500200604
The Role of Macrophages and Tissue Factor
Fuster, V. (1998) · Journal of Vascular and Interventional Radiology · doi:10.1016/s1051-0443(98)70353-7
Self-citationJernberg, T. (2000) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
INFLAMMATION IN DIABETIC WOMEN WITH CARDIOVASCULAR DISEASE
Tuttle, H. A. (2003) · UA Campus Repository (The University of Arizona)
Fuster, V. (2002) · European Heart Journal Supplements · doi:10.1016/s1520-765x(02)90028-3
Self-citationHong, Y. J., Jeong, M. H., Choi, Y. H., Park, S. Y., Seon, H. J., Lee, H., Kim, Y. H., Cho, S. C., Cho, J. Y., Jeong, H. C., et al. (2014) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2014.3.2.79
ß-Blocker in der stabilen und instabilen koronaren Herzerkrankung
Strasser, R. H. (1997) · Springer eBooks · doi:10.1007/978-3-642-60716-5_8
Therapy of unstable angina with the low molecular weight heparins
Ageno, W., & Turpie, A. G. (2000) · Vascular Medicine · doi:10.1177/1358836x0000500404
Prognostic value of biochemical Markers in Ischaemic Heart Disease
Ravkilde, J. (1998) · Developments in cardiovascular medicine · doi:10.1007/978-94-017-2380-0_10
Markers of myocardial damage and inflammation in patients with coronary artery disease
Tzontcheva, A., & Postadzhiyan, A. (2004) · Jugoslovenska medicinska biohemija · doi:10.2298/jmh0403249t
LOPEZSENDON, J. (2001) · European Heart Journal Supplements · doi:10.1016/s1520-765x(01)90030-6
Stress Echocardiography and the Ulysses Syndrome
Picano, E. (1994) · Springer eBooks · doi:10.1007/978-3-662-02979-4_17
Nosovitsky, V. A., Ilegbusi, O. J., Jiang, J., Stone, P. H., & Feldman, C. L. (2002) · Computers in cardiology · doi:10.1109/cic.1995.482757
Clinical Intracoronary Ultrasound
Ligthart, J. M. R., & de Feyter, P. J. (2004) · Medical radiology · doi:10.1007/978-3-662-06419-1_4
Advances in the Detection of the Vulnerable Coronary Atherosclerotic Plaque
Vavuranakis, M., & Stefanadis, C. (2003)
LDL-cholesterol and coronary artery disease: where we've been, where we're going
Sumner, A. D. (2002)
Ferreira, M. D. L., Gonçalves, J. M., & Quininha, J. (2004)
How to best counteract the enemies? By ensuring adequate oxygen delivery
Neumann, F. (2002) · European Heart Journal Supplements · doi:10.1016/s1520-765x(02)90088-x
Eghiazarians, Y. E. Y., Oel, J., Raunstein, B. B., Skari, A. R. A., & Tone, P. E. H. S. (2000)
Fakhrzadeh, H., Alatab, S., Sharifi, F., Ghanaati, H., Mirarefin, M., Badamchizadeh, Z., Mostashfi, A., Hossein‐Nezhad, A., & Larijani, B. A. (2011) · Journal of Diabetes & Metabolic Disorders
Imaging of Arterial Inflammation
Tsao, C. W., & Vasan, R. S. (2013) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2013.09.010
Pandey, N. K., Shrestha, N., & Karki, P. (2015) · Health Renaissance · doi:10.3126/hren.v12i2.14110
Epidemiology of Arterial and Venous Thrombosis
Kee, F. (1999) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-59942-2_3
Plaque Disruption: Pathogenesis and Prevention
Forrester, J. S., & Shah, P. K. (1998) · Journal of Thrombosis and Thrombolysis · doi:10.1023/a:1008821814892
Bernardi, V., Cuello, J. L. L., Palacios, I. F., Rodríguez, A., Gold, H. K., Fuster, V., Fallon, J. T., & Moreno, P. (2026) · Revista Argentina de Cardiología · doi:10.7775/rac.v64i2.3381
Self-citationDhaliwal, B. S. (2009) · cIRcle (University of British Columbia) · doi:10.14288/1.0089056
SÍNTESE E PROPRIEDADES FARMACOLÓGICAS DOS DERIVADOS DE ESTILBENOS
Filho, M., & Araraquara, C. D. (2013)
Bertini, P. J. (2004) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2004.tde-19102005-114248
Role of Inflammatory Response and Thrombosis in Acute Coronary Syndromes
Fernández‐Ortíz, A. (2002) · Springer eBooks · doi:10.1007/978-3-642-57212-8_5
Incidence and mechanism of post carotid endarterectomy hypertension
Newman, J. E. (2014) · Figshare
Acute coronary syndromes. I. Recent advances in pathogenesis.
Yusoff, K. (1998) · PubMed
Anticoagulantes orais nas síndromes coronarianas agudas
Rangel, F. O. D. (2001) · Rev. SOCERJ
Pathophysiology of unstable angina: implications for secondary prevention.
Ribeiro, P. A. (2003) · PubMed
Concepts in acute coronary syndromes.
Foo, R., & BONO, D. P. D. (2000) · PubMed
Stenting the vulnerable plaque
Roy, P. K., & Waksman, R. (2007) · CRC Press eBooks · doi:10.3109/9781439804537-42
Overview of Imaging Atherosclerosis
Amirbekian, V., Amirbekian, S., Aguinaldo, J. G. S., Fuster, V., & Fayad, Z. A. (2007) · CRC Press eBooks · doi:10.1201/9781420005097-18
Self-citationOptical Coherence Tomography for Detection of Vulnerable Plaque
Achenbach, S. S., Moselewski, F., & Jang, I. (2004) · CRC Press eBooks · doi:10.1201/9781420037883.ch6
Pathophysiology Basics of Acute Myocardial Infarction
Parodi, G. (2009) · CRC Press eBooks · doi:10.3109/9780203093016-5
Risk stratification for revascularisation in acute ischaemic syndromes
Constantinides, S. S. (2005) · OpenGrey (Institut de l'Information Scientifique et Technique)
Valle, Y. L. (2016) · Creighton Digital Repository (CDR)
Simultaneous Plaque Rupture in Two Coronary Arteries Presenting as Acute Coronary Syndrome.
Chirde, S. R. (2016) · PubMed
Atherogenesis and Inflammation
Hayat, U., Thondapu, V., Tsay, T., & Barlis, P. (2016) · Interventional Cardiology · doi:10.1002/9781118983652.ch1
Nagai, R. (2004) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.93.545
Metadata
- Authors
- Fuster, V
- Affiliations
- Mount Sinai Hospital (US)
- Corresponding author
- Fuster, V
- ORCID
- Fuster, V
- Venue
- Circulation
- Published
- 1994-10
- Volume
- 90
- Issue
- 4
- Pages
- 2126-2146
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2110185147
- Cited by
- 848
- References
- 240
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 7 · 2023: 11 · 2022: 9 · 2021: 4 · 2020: 14 · 2019: 6 · 2018: 5 · 2017: 12 · 2016: 19 · 2015: 16 · 2014: 19 · 2013: 24 · 2012: 18
- FWCI
- 16.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Coronary Interventions and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- myocardial infarction, coronary artery disease, vulnerable plaque, plaque disruption, lesion type, plaque regression, thrombosis, coronary syndrome, risk factor control, lipid therapy, beta-adrenergic blockade, angiotensin-converting enzyme inhibition, antithrombotic therapy, estrogen, vascular biology
- MeSH terms
- Coronary Artery Disease, Coronary Thrombosis, Coronary Vessels, Humans, Myocardial Infarction, Lipid Metabolism
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