The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cardiovascular effects of inhaled nitric oxide in patients with left ventricular dysfunction.
Open accessAbstract
BACKGROUND: Pulmonary vascular resistance (PVR) is frequently elevated in patients with advanced heart failure. Nitric oxide (NO), which contributes to the activity of endothelium-derived relaxing factor, causes relaxation of pulmonary arteries and veins in vitro. Inhalation of NO gas causes pulmonary vasodilation in patients with primary and secondary forms of pulmonary hypertension. METHODS AND RESULTS: To test the hypothesis that inhalation of NO gas lowers PVR in patients with heart failure, we studied the hemodynamic effects of a 10-minute inhalation of NO (80 ppm) in 19 patients with New York Heart Association class III (n = 5) and class IV (n = 14) heart failure due to left ventricular (LV) dysfunction. Although inhalation of NO had no effect on pulmonary artery pressures, the PVR decreased by 31 +/- 7% (P < .001) due to a 23 +/- 7% increase (P < .001) in pulmonary artery wedge pressure and despite a 4 +/- 2% (P < .05) decrease in cardiac index. The magnitude of the decrease in PVR with inhaled NO was inversely related (r = -.713; P < .001) to the baseline PVR. Inhaled NO had no effect on heart rate, systemic arterial pressure, systemic vascular resistance, or LV peak +dP/dt or -dP/dt. CONCLUSIONS: In patients with heart failure due to LV dysfunction, inhalation of NO causes a decrease in the PVR associated with an increase in LV filling pressure. These findings predict that inhaled NO, if used alone at this dose (80 ppm), may have adverse effects in patients with LV failure.
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Cites
Inhaled Nitric Oxide as a Cause of Selective Pulmonary Vasodilatation in Pulmonary Hypertension
PEPKE-ZABA, J., HIGENBOTTAM, T. W., DINH-XUAN, A. T., STONE, D., & WALLWORK, J. (1992) · Survey of Anesthesiology · doi:10.1097/00132586-199212000-00001 · Cited by 47
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Sildenafil Improves Exercise Hemodynamics and Oxygen Uptake in Patients With Systolic Heart Failure
Lewis, G. D., Lachmann, J., Camuso, J., Lepore, J. J., Shin, J., Martinovic, M. E., Systrom, D. M., Bloch, K. D., & Semigran, M. J. (2007) · Circulation · doi:10.1161/circulationaha.106.626226 · Cited by 353
Bonderman, D., Ghio, S., Felix, S. B., Ghofrani, H.-A., Michelakis, E., Mitrovic, V., Oudiz, R. J., Boateng, F., Scalise, A.-V., Roessig, L., et al. (2013) · Circulation · doi:10.1161/circulationaha.113.001458 · Cited by 326
Chronic sodium nitrite therapy augments ischemia-induced angiogenesis and arteriogenesis
Kumar, D., Branch, B. G., Pattillo, C. B., Hood, J., Thoma, S., Simpson, S., Illum, S., Arora, N., Chidlow, J. H., Langston, W., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711480105 · Cited by 187
Dietary nitrate supplementation improves revascularization in chronic ischemia
Hendgen-Cotta, U. B., Luedike, P., Totzeck, M., Kropp, M., Schicho, A., Stock, P., Rammos, C., Niessen, M., Heiss, C., Lundberg, J. O., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.112912 · Cited by 110
L‐Arginine reduces heart rate and improves hemodynamics in severe congestive heart failure
Bocchi, E. A., De Moraes, A. V., Esteves‐Filho, A., Bacal, F., Auler, J. O., Carmona, M. J., Bellotti, G., & Ramires, A. F. (2000) · Clinical Cardiology · doi:10.1002/clc.4960230314 · Cited by 45
Metadata
- Authors
- Loh, E., Stamler, J. S., Hare, J. M., Loscalzo, J., & Colucci, W. S.
- Venue
- Circulation
- Published
- 1994-12
- Volume
- 90
- Issue
- 6
- Pages
- 2780-2785
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2161671586
- Cited by
- 258
- References
- 1
- FWCI
- 10.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Loh, E., Stamler, J. S., Hare, J. M., Loscalzo, J., & Colucci, W. S. (1994). Cardiovascular effects of inhaled nitric oxide in patients with left ventricular dysfunction. Circulation. https://doi.org/10.1161/01.cir.90.6.2780
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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