The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Physiological Basis of Myocardial Contrast Enhancement in Fast Magnetic Resonance Images of 2-Day-Old Reperfused Canine Infarcts
Abstract
Background Contrast-enhanced fast magnetic resonance (MR) images of acute, reperfused human infarcts demonstrate regions of hypoenhancement and hyperenhancement. The relations between the spatial extent and time course of these enhancement patterns to myocardial risk, infarct, and no-reflow regions have not been well characterized. Methods and Results The proximal left anterior descending coronary artery was occluded in 11 closed-chest dogs for 90 minutes followed by 2 days of reperfusion. Regional blood flow was determined by use of radioactive microspheres. The animals were studied at the 2-day time point with contrast-enhanced fast MRI (Signa 1.5 T, General Electric). Thioflavin-S was administered to demarcate no-reflow regions. The hearts were then excised, sectioned into five base-to-apex slices, stained with 2,3,5-triphenyltetrazolium chloride (TTC), and photographed under room light (for TTC) and ultraviolet light (for thioflavin). The spatial extents of thioflavin-negative, TTC-negative, and risk regions were compared planimetrically with MRI hypoenhanced and hyperenhanced regions. The spatial locations of subendocardial hypoenhancement in MR images correlated closely with those of thioflavin-negative regions. Microsphere blood flow in these regions was significantly reduced compared with remote regions (0.37±0.09 versus 0.88±0.10 mL/min per gram, respectively, P <.001) and with baseline (0.37±0.09 versus 0.87±0.15 mL/min per gram, P <.01). The spatial extent of hyperenhancement was smaller than the risk region ( r =.64, slope=0.48, P <.001) but highly correlated with TTC-negative regions and were, on average, 12% larger ( r =.93, slope=1.12, P =.035). Conclusions In contrast-enhanced MR images of 2-day-old reperfused canine infarcts, myocardial regions of hypoenhancement are related to the no-reflow phenomenon. Approximately 90% of the myocardium within hyperenhanced regions is nonviable.
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Citations
Cites
The “no-reflow” phenomenon after temporary coronary occlusion in the dog
Kloner, R. A., Ganote, C. E., & Jennings, R. B. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107898 · Cited by 1,842
Cited by
Clinical indications for cardiovascular magnetic resonance (CMR): Consensus Panel report?
PENNELL, D. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.06.040 · Cited by 747
Amado, L. C., Gerber, B. L., Gupta, S. N., Rettmann, D. W., Szarf, G., Schock, R., Nasir, K., Kraitchman, D. L., & Lima, J. A. C. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.09.020 · Cited by 508
Self-citationWeir, R. A. P., Murphy, C. A., Petrie, C. J., Martin, T. N., Balmain, S., Clements, S., Steedman, T., Wagner, G. S., Dargie, H. J., & McMurray, J. J. V. (2010) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.109.897439 · Cited by 86
Metadata
- Authors
- Judd, R. M., Lugo-Olivieri, C. H., Arai, M., Kondo, T., Croisille, P., Lima, J. A. C., Mohan, V., Becker, L. C., & Zerhouni, E. A.
- Venue
- Circulation
- Published
- 1995-10
- Volume
- 92
- Issue
- 7
- Pages
- 1902-1910
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2066789731
- Cited by
- 463
- References
- 1
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Physiological Basis of Myocardial Contrast Enhancement in Fast Magnetic Resonance Images of 2-Day-Old Reperfused Canine Infarcts. https://app.cochat.ai/papers/10.1161/01.cir.92.7.1902
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- Judd, R. M., Lugo-Olivieri, C. H., Arai, M., Kondo, T., Croisille, P., Lima, J. A. C., Mohan, V., Becker, L. C., & Zerhouni, E. A. (1995). Physiological Basis of Myocardial Contrast Enhancement in Fast Magnetic Resonance Images of 2-Day-Old Reperfused Canine Infarcts. Circulation. https://doi.org/10.1161/01.cir.92.7.1902
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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