The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
LDL-Apheresis Atherosclerosis Regression Study (LAARS): Effect of Aggressive Versus Conventional Lipid Lowering Treatment on Coronary Atherosclerosis
Open accessAbstract
Background Intensive lipid lowering may retard the progression of coronary atherosclerosis. LDL-apheresis has the potential to decrease LDL cholesterol to very low levels. To assess the effect of more aggressive lipid lowering with LDL-apheresis, we set up a randomized study in men with hypercholesterolemia and severe coronary atherosclerosis. Methods and Results For 2 years, 42 men were treated with either biweekly LDL-apheresis plus medication or medication alone. In both groups a dose of simvastatin of 40 mg per day was administered. Baseline (mean±SD) LDL cholesterol was 7.8±1.9 mmol·L −1 and 7.9±2.3 mmol·L −1 in the apheresis and medication groups, respectively. The mean reduction in LDL cholesterol was 63% (to 3.0 mmol·L −1 ) and 47% (to 4.1 mmol·L −1 ), respectively. Primary quantitative coronary angiographic end points were changes in average mean segment diameter and minimal obstruction diameter. No differences between the apheresis and medication groups were found in mean segment diameter (−0.01±0.16 mm versus 0.03±0.16 mm, respectively) or in minimal obstruction diameter (−0.01±0.13 mm versus 0.01±0.11 mm, respectively), expressed as means per patient. On the basis of coronary segment, mean percent stenosis of all lesions showed a tendency to decrease; only in the apheresis group more minor lesions disappeared in comparison to the medication group. On bicycle exercise tests, the time to 0.1 mV ST-segment depression increased significantly by 39% and the maximum level of ST depression decreased significantly by 0.07 mV in the apheresis group versus no changes in the medication group. Conclusions Two years of lipid lowering both with medication alone or LDL-apheresis with medication showed angiographic arrest of the progression of coronary artery disease. However, more aggressive treatment induced functional improvement, which may precede anatomic changes.
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Cited by
Familial Hypercholesterolemia: Screening, diagnosis and management of pediatric and adult patients
Goldberg, A. C., Hopkins, P. N., Toth, P. P., Ballantyne, C. M., Rader, D. J., Robinson, J. G., Daniels, S. R., Gidding, S. S., de Ferranti, S. D., Ito, M. K., et al. (2011) · Journal of clinical lipidology · doi:10.1016/j.jacl.2011.03.001 · Cited by 622
Guidelines for the diagnosis and management of heterozygous familial hypercholesterolemia
Civeira, F. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2003.11.010 · Cited by 495
Lea, A. P., & McTavish, D. (1997) · Drugs · doi:10.2165/00003495-199753050-00011 · Cited by 290
Recommendations for the use of LDL apheresis
Thompson, G. R. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.02.009 · Cited by 270
Pijlman, A. H., Huijgen, R., Verhagen, S. N., Imholz, B. P. M., Liem, A. H., Kastelein, J. J. P., Abbink, E. J., Stalenhoef, A. F. H., & Visseren, F. L. J. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.09.014 · Cited by 238
Self-citation
Metadata
- Authors
- Kroon, A. A., Aengevaeren, W. R. M., van der Werf, T., Uijen, G. J. H., Reiber, J. H. C., Bruschke, A. V. G., & Stalenhoef, A. F. H.
- Venue
- Circulation
- Published
- 1996-05-15
- Volume
- 93
- Issue
- 10
- Pages
- 1826-1835
- ISSN
- 0009-7322
- 1524-4539
- OpenAlex
- W1991899835
- Cited by
- 275
- References
- 53
- FWCI
- 22.50
- Type
- journal article
- Language
- en
- Open access
- green
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- Kroon, A. A., Aengevaeren, W. R. M., van der Werf, T., Uijen, G. J. H., Reiber, J. H. C., Bruschke, A. V. G., & Stalenhoef, A. F. H. (1996). LDL-Apheresis Atherosclerosis Regression Study (LAARS): Effect of Aggressive Versus Conventional Lipid Lowering Treatment on Coronary Atherosclerosis. Circulation. https://doi.org/10.1161/01.cir.93.10.1826
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