The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Influence of Pregnancy on the Risk for Cardiac Events in Patients With Hereditary Long QT Syndrome
Abstract
Background —The effects of pregnancy on women with the hereditary long QT syndrome are currently unknown. The appropriate medical management of pregnant patients with the long QT syndrome has not been established. Methods and Results —The study was a retrospective analysis of the 422 women (111 probands affected with the long QT syndrome and 311 first-degree relatives) enrolled in the long QT syndrome registry who had one or more pregnancies. The first-degree relatives were classified as affected (QTc >0.47), borderline (QTc=0.45 to 0.47), and unaffected (QTc <0.45). Cardiac events were defined as the combined incidence of long QT syndrome–related death, aborted cardiac arrest, and syncope. The incidence of cardiac events was compared during equal prepregnancy, pregnancy, and postpartum intervals (40 weeks each). Multivariate logistic regression analysis was performed by use of a mixed-effects model to identify independent predictors of cardiac events among probands. The pregnancy and postpartum intervals were not associated with cardiac events among first-degree relatives. The postpartum interval was independently associated with cardiac events among probands (odds ratio [OR], 40.8; 95% confidence interval [CI], 3.1 to 540; P =.01); the pregnancy interval was not associated with cardiac events. Treatment with β-adrenergic blockers was independently associated with a decrease in the risk for cardiac events among probands (OR, 0.023; 95% CI, 0.001 to 0.44; P =.01). Conclusions —The postpartum interval is associated with a significant increase in risk for cardiac events among probands with the long QT syndrome but not among first-degree relatives. Prophylactic treatment with β-adrenergic blockers should be continued during the pregnancy and postpartum intervals in probands with the long QT syndrome.
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Cites
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Self-citationSCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome
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Self-citationThe long QT syndrome. Prospective longitudinal study of 328 families.
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Self-citationIdiopathic long QT syndrome: Progress and questions
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Priori, S. G., Blomström-Lundqvist, C., Mazzanti, A., Blom, N., Borggrefe, M., Camm, J., Elliott, P. M., Fitzsimons, D., Hatala, R., Hindricks, G., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv316 · Cited by 3,893
Zeppenfeld, K., Tfelt-Hansen, J., de Riva, M., Winkel, B. G., Behr, E. R., Blom, N. A., Charron, P., Corrado, D., Dagres, N., de Chillou, C., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac262 · Cited by 3,140
ACC/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities
Epstein, A. E., DiMarco, J. P., Ellenbogen, K. A., Estes, N. A. M., Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.02.032 · Cited by 2,546
2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy
Regitz-Zagrosek, V., Roos-Hesselink, J. W., Bauersachs, J., Blomström-Lundqvist, C., Cífková, R., De Bonis, M., Iung, B., Johnson, M. R., Kintscher, U., Kranke, P., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy340 · Cited by 2,292
ESC Guidelines on the management of cardiovascular diseases during pregnancy
Endorsed by the European Society of Gynecology (ESG), T. A. F. E. P. C. (., Authors/Task Force Members, Regitz-Zagrosek, V., Blomstrom Lundqvist, C., Borghi, C., Cifkova, R., Ferreira, R., Foidart, J.-M., Gibbs, J. S. R., Gohlke-Baerwolf, C., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr218 · Cited by 1,924
Metadata
- Authors
- Rashba, E. J., Zareba, W., Moss, A. J., Hall, W. J., Robinson, J., Locati, E. H., Schwartz, P. J., & Andrews, M.
- Venue
- Circulation
- Published
- 1998-02-10
- Volume
- 97
- Issue
- 5
- Pages
- 451-456
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1977670821
- Cited by
- 273
- References
- 42
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rashba, E. J., Zareba, W., Moss, A. J., Hall, W. J., Robinson, J., Locati, E. H., Schwartz, P. J., & Andrews, M. (1998). Influence of Pregnancy on the Risk for Cardiac Events in Patients With Hereditary Long QT Syndrome. Circulation. https://doi.org/10.1161/01.cir.97.5.451
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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