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The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Prospective Study of C-Reactive Protein and the Risk of Future Cardiovascular Events Among Apparently Healthy Women

Open access
Ridker, Paul M., Buring, Julie E., Shih, Jessie, Matias, Mathew, Hennekens, Charles H.·1998·Circulation

Abstract

Background —C-reactive protein (CRP) predicts risk of myocardial infarction (MI) and stroke among apparently healthy men, but in women, virtually no data are available. Methods and Results —CRP was measured in baseline blood samples from 122 apparently healthy participants in the Women’s Health Study who subsequently suffered a first cardiovascular event and from 244 age- and smoking-matched control subjects who remained free of cardiovascular disease during a 3-year follow-up period. Women who developed cardiovascular events had higher baseline CRP levels than control subjects ( P =0.0001), such that those with the highest levels at baseline had a 5-fold increase in risk of any vascular event (RR=4.8; 95% CI, 2.3 to 10.1; P =0.0001) and a 7-fold increase in risk of MI or stroke (RR=7.3; 95% CI, 2.7 to 19.9; P =0.0001). Risk estimates were independent of other risk factors, and prediction models that included CRP provided a better method to predict risk than models that excluded CRP (all P values <0.01). In stratified analyses, CRP was a predictor among subgroups of women with low as well as high risk as defined by other cardiovascular risk factors. Conclusions —In these prospective data among women, CRP is a strong independent risk factor for cardiovascular disease that adds to the predictive value of risk models based on usual factors alone.

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Metadata

Authors
Ridker, P. M., Buring, J. E., Shih, J., Matias, M., & Hennekens, C. H.
Venue
Circulation
Published
1998-08-25
Volume
98
Issue
8
Pages
731-733
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W2135568455
Cited by
1,642
References
11
FWCI
75.09
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Prospective Study of C-Reactive Protein and the Risk of Future Cardiovascular Events Among Apparently Healthy Women. https://app.cochat.ai/papers/10.1161/01.cir.98.8.731
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Ridker, P. M., Buring, J. E., Shih, J., Matias, M., & Hennekens, C. H. (1998). Prospective Study of C-Reactive Protein and the Risk of Future Cardiovascular Events Among Apparently Healthy Women. Circulation. https://doi.org/10.1161/01.cir.98.8.731

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