Cited by 344Lipid metabolism and disordersLipoproteins and Cardiovascular HealthParaoxonase enzyme and polymorphisms

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Lipoprotein Lipase Mutations, Plasma Lipids and Lipoproteins, and Risk of Ischemic Heart Disease: A Meta-Analysis

Wittrup, Hans H., Tybjærg-Hansen, Anne, Nordestgaard, Børge G.·1999·Circulation

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Abstract

Background —We assessed in meta-analyses the effect of the Gly188Glu, Asp9Asn, Asn291Ser, and Ser447Ter substitutions in lipoprotein lipase in the heterozygous state on lipid metabolism and risk of ischemic heart disease (same order used below). Methods and Results —In 29 separate studies, 20 903 white subjects were screened for ≥1 of these substitutions; each meta-analysis included only some of these individuals. In population-based studies, heterozygote frequencies ranged from 0.04% to 0.2%, 2% to 4%, 1% to 7%, and 17% to 22% for the respective substitutions. Postheparin plasma lipoprotein lipase activity decreased 53% (95% CI, 31% to 75%) (only 1 study), 30% (22% to 37%), and 22% (8% to 35%) and was unchanged at 4% (−10% to 19%), respectively. Plasma triglycerides increased 78% (95% CI, 64% to 92%), 20% (9% to 33%), and 31% (20% to 43%) and decreased 8% (4% to 11%), respectively. HDL cholesterol decreased 0.25 mmol/L (0.18 to 0.32), 0.08 mmol/L (0.04 to 0.12), and 0.12 mmol/L (0.10 to 0.15) and increased 0.04 mmol/L (0.02 to 0.06), respectively. Odds ratios for ischemic heart disease were 4.9 (95% CI, 1.2 to 20) (only 1 study), 1.4 (0.8 to 2.4), 1.2 (0.9 to 1.5), and 0.8 (0.7 to 1.0), respectively. Subgroup analysis indicated that women with the Asn291Ser substitution may have an increased risk of ischemic heart disease. Conclusions —These meta-analyses suggest that compared with noncarriers, carriers of the Gly188Glu, Asp9Asn, and Asn291Ser substitutions have an atherogenic lipoprotein profile, whereas carriers of the Ser447Ter substitution have a protective lipoprotein profile. Accordingly, risk of ischemic heart disease in heterozygous carriers is increased for Gly188Glu carriers; at most, the increase is borderline for Asp9Asn and Asn291Ser carriers; and risk is possibly decreased for Ser447Ter carriers.

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Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease
(1959) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/22.4.719 · Cited by 14,689
The Metabolic and Molecular Bases of Inherited Disease
Scriver, R. C. (1995) · Medical Entomology and Zoology · Cited by 12,101
Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies
Hokanson, J. E., & Austin, M. A. (1996) · Journal of Cardiovascular Risk · doi:10.1097/00043798-199604000-00014 · Cited by 1,706
Some Statistical Methods for Combining Experimental Results
Laird, N. M., & Mosteller, F. C. (1990) · International Journal of Technology Assessment in Health Care · doi:10.1017/s0266462300008916 · Cited by 564
Cochrane Collaboration Handbook
Mulrow, C. (1996) · Medical Entomology and Zoology · Cited by 403
High density lipoproteins and coronary heart disease
Barter, P. J., & Rye, K.-A. (1996) · Atherosclerosis · doi:10.1016/0021-9150(95)05675-0 · Cited by 377
Selective Retention of VLDL, IDL, and LDL in the Arterial Intima of Genetically Hyperlipidemic Rabbits In Vivo: Molecular Size as a Determinant of Fractional Loss From the Intima–Inner Media
Nordestgaard, B. G., Wootton, R., & Lewis, B. (1995) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.15.4.534 · Cited by 334
Self-citation
Premature Atherosclerosis in Patients with Familial Chylomicronemia Caused by Mutations in the Lipoprotein Lipase Gene
Benlian, P., Gennes, J. L. D., Foubert, L., Zhang, H., Gagné, S., & Hayden, M. R. (1996) · New England Journal of Medicine · doi:10.1056/nejm199609193351203 · Cited by 296
Familial lipoprotein lipase deficiency and other causes of the chylomicronemia syndrome.
Brunzell, J. (1989) · Medical Entomology and Zoology · Cited by 285
A lipoprotein lipase mutation (Asn291Ser) is associated with reduced HDL cholesterol levels in premature atherosclerosis
Reymer, P. W. A., Gagné, E., Groenemeyer, B. E., Zhang, H., Forsyth, I., Jansen, H., Seidell, J. C., Kromhout, D., Lie, K. I., Kastelein, J., et al. (1995) · Nature Genetics · doi:10.1038/ng0595-28 · Cited by 239

Show all 45 references

Research works printed but not linked: 13

10.1161/circ.96.3.733 · DOI
10.1161/circ.95.12.2628 · DOI
10.1161/atvb.15.4.468 · DOI
10.1161/atv91.14.7.7912549 · DOI
10.1161/atvb.15.10.1704 · DOI
10.1161/circ.94.12.3239 · DOI
10.1161/circ.96.6.1737 · DOI
10.1161/circ.94.8.1913 · DOI
10.1161/atvb.15.10.1695 · DOI
Jemaa R, Fumeron F, Poirier O, Lecerf L, Evans A, Arveiler D, Luc G, Cambou JP, Bard JM, Fruchart JC, Apfelbaum, Cambien F, Tiret L. Lipoprotein lipase gene polymorphisms: associations with myocardial infarction and lipoprotein levels: the ECTIM study. J Lipid Res. 1995;36:2141–2146.
Armitage P Berry G eds. Statistical Methods in Medical Research. Oxford UK: Blackwell Science Ltd; 1994:66–71 85–88 301–311 527–528 560–561.
10.1161/atvb.15.4.534 · DOI
10.1161/atvb.17.10.1969 · DOI

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Authors: Wittrup, H. H., Tybjærg-Hansen, A., & Nordestgaard, B. G.
Affiliations: Herlev Hospital (DK)
From the Department of Clinical Biochemistry, Herlev University Hospital (H.H.W., A.T.-H.), Herlev, Denmark, and Department of Clinical Biochemistry, Glostrup University Hospital (B.G.N.), Glostrup, Denmark.
ORCID: Nordestgaard, Børge G.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1999-06-08
Volume: 99
Issue: 22
Pages: 2901-2907
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.99.22.2901
OpenAlex: W2011468836
Cited by: 344
References: 45
Citations by year: 2026: 2 · 2025: 8 · 2024: 4 · 2023: 1 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 11 · 2016: 17 · 2015: 13 · 2014: 11 · 2013: 12 · 2012: 11
FWCI: 3.64
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Funders: Hjerteforeningen
Sundhed og Sygdom, Det Frie Forskningsråd
Medical Research Council
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords: lipoprotein lipase, heterozygous carriers, ischemic heart disease risk, plasma triglycerides, HDL cholesterol, lipid metabolism, sex differences, genetic susceptibility
MeSH terms: Apolipoproteins B, Cholesterol, Cross-Sectional Studies, Female, Heparin, Humans, Lipids, Lipoprotein Lipase, Lipoproteins, Cholesterol, HDL, Male, Mutation, Risk Factors, Triglycerides, Case-Control Studies, Apolipoprotein A-I, Myocardial Ischemia

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Lipoprotein Lipase Mutations, Plasma Lipids and Lipoproteins, and Risk of Ischemic Heart Disease: A Meta-Analysis

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