Cited by 1,099Cardiovascular and exercise physiologyHeart Failure Treatment and ManagementCardiac Health and Mental Health

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Randomized, Controlled Trial of Long-Term Moderate Exercise Training in Chronic Heart Failure: Effects on Functional Capacity, Quality of Life, and Clinical Outcome

Belardinelli, Romualdo, Georgiou, Demetrios, Cianci, Giovanni, Purcaro, Augusto·1999·Circulation

DOI 10.1161/01.cir.99.9.1173

Open this paper in CoChat — free account

Abstract

BACKGROUND: It is still a matter of debate whether exercise training (ET) is a beneficial treatment in chronic heart failure (CHF). METHODS AND RESULTS: To determine whether long-term moderate ET improves functional capacity and quality of life in patients with CHF and whether these effects translate into a favorable outcome, 110 patients with stable CHF were initially recruited, and 99 (59+/-14 years of age; 88 men and 11 women) were randomized into 2 groups. One group (group T, n=50) underwent ET at 60% of peak &f1;O2, initially 3 times a week for 8 weeks, then twice a week for 1 year. Another group (group NT, n=49) did not exercise. At baseline and at months 2 and 14, all patients underwent a cardiopulmonary exercise test, while 74 patients (37 in group T and 37 in group NT) with ischemic heart disease underwent myocardial scintigraphy. Quality of life was assessed by questionnaire. Ninety-four patients completed the protocol (48 in group T and 46 in group NT). Changes were observed only in patients in group T. Both peak &f1;O2 and thallium activity score improved at 2 months (18% and 24%, respectively; P<0. 001 for both) and did not change further after 1 year. Quality of life also improved and paralleled peak VO2. Exercise training was associated both with lower mortality (n=9 versus n=20 for those with training versus those without; relative risk (RR)=0.37; 95% CI, 0.17 to 0.84; P=0.01) and hospital readmission for heart failure (5 versus 14; RR=0.29; 95% CI, 0.11 to 0.88; P=0.02). Independent predictors of events were ventilatory threshold at baseline (beta-coefficient=0.378) and posttraining thallium activity score (beta-coefficient -0.165). CONCLUSIONS: Long-term moderate ET determines a sustained improvement in functional capacity and quality of life in patients with CHF. This benefit seems to translate into a favorable outcome.

Integrity signals

Registry

Crossref · 10.1161/01.cir.99.9.1173

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Recommendations for Quantitation of the Left Ventricle by Two-Dimensional Echocardiography
Schiller, N. B., Shah, P. M., Crawford, M., DeMaria, A. N., Devereux, R. B., Feigenbaum, H., Gutgesell, H. P., Reichek, N., Sahn, D. J., Schnittger, I., et al. (1989) · Journal of the American Society of Echocardiography · doi:10.1016/s0894-7317(89)80014-8 · Cited by 8,110
A new method for detecting anaerobic threshold by gas exchange
Beaver, W. L., Wasserman, K., & Whipp, B. J. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.60.6.2020 · Cited by 4,103
Assessment of patient outcome with the Minnesota Living with Heart Failure questionnaire: Reliability and validity during a randomized, double-blind, placebo-controlled trial of pimobendan
Rector, T. S., & Cohn, J. N. (1992) · American Heart Journal · doi:10.1016/0002-8703(92)90986-6 · Cited by 1,020
Controlled trial of physical training in chronic heart failure. Exercise performance, hemodynamics, ventilation, and autonomic function.
Coats, A. J. S., Adamopoulos, S. N., Radaelli, A., McCance, A. J., Meyer, T. E., Bernardi, L., Soldà, P. L., Davey, P. P., ORMEROD, O. J. M., & Forfar, C. (1992) · Circulation · doi:10.1161/01.cir.85.6.2119 · Cited by 953
Contribution of skeletal muscle atrophy to exercise intolerance and altered muscle metabolism in heart failure.
MANCINI, D. M., Walter, G., Reichek, N., Lenkinski, R. E., McCully, K. K., Mullen, J. L., & Wilson, J. R. (1992) · Circulation · doi:10.1161/01.cir.85.4.1364 · Cited by 736
Exercise training in patients with severe left ventricular dysfunction. Hemodynamic and metabolic effects.
Sullivan, M. J., Higginbotham, M. B., & Cobb, F. R. (1988) · Circulation · doi:10.1161/01.cir.78.3.506 · Cited by 697
Vagal stimulation and prevention of sudden death in conscious dogs with a healed myocardial infarction.
Vanoli, E., De Ferrari, G. M., Stramba-Badiale, M., Hull, S. S., Foreman, R. D., & Schwartz, P. J. (1991) · Circulation Research · doi:10.1161/01.res.68.5.1471 · Cited by 681
Physical Training Improves Endothelial Function in Patients With Chronic Heart Failure
Hornig, B., Maier, V., & Drexler, H. (1996) · Circulation · doi:10.1161/01.cir.93.2.210 · Cited by 628
Physical training in patients with stable chronic heart failure: Effects on cardiorespiratory fitness and ultrastructural abnormalities of leg muscles
Hambrecht, R., Niebauer, J., Fiehn, E., Kälberer, B., Offner, B., Hauer, K., Riede, U., Schlierf, G., Kübler, W., & Schuler, G. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)00568-b · Cited by 580
Guidelines for exercise testing
Feild, M. D. J. (1986) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(86)80208-x · Cited by 528

Show all 25 references

Research works printed but not linked: 11

10.1161/circ.78.3.3409495 · DOI
10.1161/circ.85.6.1591831 · DOI
10.1161/circ.69.6.6713619 · DOI
10.1161/circ.89.2.8313542 · DOI
10.1161/circ.97.6.553 · DOI
10.1161/circ.85.3.1537130 · DOI
10.1161/circ.93.2.210 · DOI
10.1161/circ.67.6.6851015 · DOI
10.1161/circ.94.5.978 · DOI
10.1161/res.68.5.2019002 · DOI
Inglese E, Brambilla M, Dondi M, Coccolini S, Cannizzaro G, Pirelli S, Cappagli M, Bertoli D, Pieri PL, Moscatelli G, Giordano A, Trani C, Bertelli P. Thallium-201: what do we gain from new clinical protocols and acquisition procedures? J Nucl Biol Med.. 1992;36:253–258.

Sorted by citations

Items 201–300 of 1,000

Exercise-based cardiac rehabilitation for chronic heart failure: the EXTRAMATCH II individual participant data meta-analysis
Taylor, R. S., Walker, S., Ciani, O., Warren, F. C., Smart, N. A., Piepoli, M. F., & Davos, C. H. (2019) · Health Technology Assessment · doi:10.3310/hta23250 · Cited by 80
The effect of endurance training on exercise capacity following cardiac resynchronization therapy in chronic heart failure patients: a pilot trial
Conraads, V. M., Vanderheyden, M., Paelinck, B. P., Verstreken, S., Blankoff, I., Miljoen, H., SUTTER, J. D., & Beckers, P. J. (2007) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e32801164b3 · Cited by 80
Effects of exercise training on cardiovascular adrenergic system
Leosco, D., Parisi, V., Femminella, G. D., Formisano, R., Petraglia, L., Allocca, E., & Bonaduce, D. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00348 · Cited by 81
“It has been generally accepted that regular physical activity is associated with beneficial effects on the cardiovascular system (Belardinelli et al., 1999; Hambrecht et al., 2000; Piepoli et al., 2004; Rinaldi et al., 2006; Flynn et al., 2009; Giallauria et al., 2013).”
Background
Exercise and Physical Activity in the Prevention and Treatment of Atherosclerotic Cardiovascular Disease
Thompson, P. D., Büchner, D. M., Piña, I. L., Balady, G. J., Williams, M. A., Marcus, B. H., Berra, K. A., Blair, S. N., Costa, F., Franklin, B. A., et al. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000089628.63625.d4 · Cited by 84
Dipeptidyl peptidase-4 inhibitor improved exercise capacity and mitochondrial biogenesis in mice with heart failure via activation of glucagon-like peptide-1 receptor signalling
Takada, S., Masaki, Y., Kinugawa, S., Matsumoto, J., Furihata, T., Mizushima, W., Kadoguchi, T., Fukushima, A., Homma, T., Takahashi, M., et al. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw182 · Cited by 78
Exercise reverses preamyloid oligomer and prolongs survival in αB-crystallin-based desmin-related cardiomyopathy
Maloyan, A., Gulick, J. M., Glabe, C. G., Kayed, R., & Robbins, J. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609202104 · Cited by 80
Hemodynamic Responses During Aerobic and Resistance Exercise
Karlsdottir, A. E., Foster, C., Porcari, J. P., Palmer-McLean, K., White-Kube, R., & Backes, R. (2002) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200205000-00008 · Cited by 79
Selective low-level leg muscle training alleviates dyspnea in patients with heart failure
Beniaminovitz, A., Lang, C. C., LaManca, J. J., & MANCINI, D. M. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02342-2 · Cited by 79
Effect of Psychosocial Factors on Physiologic Outcomes in Patients with Heart Failure
Moser, D. K., & Worster, P. L. (2000) · The Journal of Cardiovascular Nursing · doi:10.1097/00005082-200007000-00008 · Cited by 79
The effects of exercise training on the kinetics of oxygen uptake in patients with chronic heart failure
Roditis, P., Dimopoulos, S. K., Sakellariou, D., Sarafoglou, S., Kaldara, E., Venetsanakos, J., Vogiatzis, J., ANASTASIOU‐NANA, M. I., Roussos, C., & Nanas, S. (2007) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e32808621a3 · Cited by 79
Exercise training improves peripheral chemoreflex function in heart failure rabbits
Li, Y.-L., Ding, Y., Agnew, C., & Schultz, H. D. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90533.2008 · Cited by 78
Exercise training improves aortic depressor nerve sensitivity in rats with ischemia-induced heart failure
Rondon, E., Brasileiro‐Santos, M. S., Moreira, E. D., Rondon, M. U. P. B., Mattos, K. C., Coelho, M. A., da Silva, G. J. J., Brum, P. C., Fiorino, P., Irigoyen, M. C., et al. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01352.2005 · Cited by 76
“The consistent findings of reduced sympathetic nerve activity after exercise training (18, 26) may lead to an increase in quality of life with exercise (3), possibly reducing the mortality”
Background
Exercise training early after acute myocardial infarction reduces stress-induced hypoperfusion and improves left ventricular function
Giallauria, F., Acampa, W., Ricci, F., Vitelli, A., Torella, G., Lucci, R., Prete, G. D., Zampella, E., Assante, R., Rengo, G., et al. (2012) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-012-2302-x · Cited by 78
Cardiopulmonary exercise testing is more accurate than ECG-stress testing in diagnosing myocardial ischemia in subjects with chest pain
Belardinelli, R., Lacalaprice, F., Tiano, L., Muçaj, A., & Perna, G. P. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.04.102 · Cited by 76
Self-citation
Skeletal muscle training in chronic heart failure
Piepoli, M. F., Scott, A., Capucci, A., & Coats, A. J. S. (2001) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2001.00831.x · Cited by 76
Recovery of Cardiac Autonomic Responsiveness with Low-Intensity Physical Training in Patients with cHronic Heart Failure
Malfatto, G., Branzi, G., Riva, B., Sala, L., Leonetti, G., & Facchini, M. (2002) · European Journal of Heart Failure · doi:10.1016/s1388-9842(01)00221-5 · Cited by 72
Effects of exercise training on aerobic capacity and quality of life in individuals with heart failure
Collins, E. G., Langbein, W. E., Dilan-Koetje, J., Bammert, C., Hanson, K. J., Reda, D. J., & Edwards, L. C. (2004) · Heart & Lung · doi:10.1016/j.hrtlng.2003.12.009 · Cited by 75
The effect of cardiac rehabilitation on quality of life, anxiety and depression in patients with congestive heart failure. A randomized controlled trial, short-term results.
Külcü, D. G., Kurtaiş, Y., Tur, B. S., Güleç, S., & Seçkin, B. (2007) · PubMed · Cited by 75
Exercise, Nrf2 and Antioxidant Signaling in Cardiac Aging
Narasimhan, M., & Rajasekaran, N. S. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00241 · Cited by 78
“Prior studies have demonstrated that a short- and long-term MET in animals and humans with ischemic heart disease, and cardiac heart failure showed improvements in myocardial perfusion and functional capacity (Laughlin and McAllister, 1992; Belardinelli et al., 1998, 1999).”
Background
Exercise training enhances baroreflex control of heart rate by a vagal mechanism in rabbits with heart failure
Liu, J., Kulakofsky, J., & Zucker, I. H. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00039.2002 · Cited by 74
“(4) have shown increased survival and reduced coronary events in patients with CHF who underwent a 5-yr Ex program.”
Background
Effects of Interval Cycle Training With or Without Strength Training on Vascular Reactivity in Heart Failure Patients
Anagnostakou, V., Chatzimichail, K., Dimopoulos, S. K., Karatzanos, E., Papazachou, O., Tasoulis, A., ANASTASIOU‐NANA, M. I., Roussos, C., & Nanas, S. (2011) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2011.02.009 · Cited by 73
Exercise Training and Implantable Cardioverter-Defibrillator Shocks in Patients With Heart Failure
Piccini, J. P., Hellkamp, A. S., Whellan, D. J., Ellis, S. J., Keteyian, S. J., Kraus, W. E., Hernandez, A. F., Daubert, J. P., Piña, I. L., & O’Connor, C. M. (2013) · JACC Heart Failure · doi:10.1016/j.jchf.2013.01.005 · Cited by 73
Optimal Pharmacologic and Non-pharmacologic Management of Cardiac Transplant Candidates: Approaches to Be Considered Prior to Transplant Evaluation: International Society for Heart and Lung Transplantation Guidelines for the Care of Cardiac Transplant Candidates—2006
Jessup, M. L., Banner, N. R., Brozena, S. C., Campana, C., Costard‐Jäckle, A., Dengler, T. J., Hunt, S. A., Metra, M., Rahmel, A. O., Renlund, D. G., et al. (2006) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2006.06.007 · Cited by 73
Exercise-based cardiac rehabilitation for adults with heart failure
Molloy, C., Long, L., Mordi, I. R., Bridges, C., Sagar, V. A., Davies, E. J., Coats, A. J. S., Dalal, H. M., Rees, K., Singh, S., et al. (2024) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003331.pub6 · Cited by 93
Mechanisms of the Improvement in Peak VO2 With Exercise Training in Heart Failure With Reduced or Preserved Ejection Fraction
Tucker, W. J., Lijauco, C. C., Hearon, C. M., Angadi, S. S., Nelson, M. D., Sarma, S., Nanayakkara, S., Gerche, A. L., & Haykowsky, M. J. (2017) · Heart Lung and Circulation · doi:10.1016/j.hlc.2017.07.002 · Cited by 72
Endurance Exercise Training in Older Patients with Heart Failure: Results from a Randomized, Controlled, Single‐Blind Trial
Brubaker, P. H., Moore, J. B., Stewart, K. P., Wesley, D. J., & Kitzman, D. W. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02499.x · Cited by 70
The Effects of Two Modes of Exercise on Aerobic Fitness and Fat Mass in an Overweight Population
Wallman, K. E., Plant, L. A., Rakimov, B., & Maiorana, A. (2009) · Research in Sports Medicine · doi:10.1080/15438620903120215 · Cited by 72
Exercise & Sports Science Australia Position Statement on exercise training and chronic heart failure
Selig, S., Levinger, I., Williams, A. D., Smart, N. A., Holland, D. J., Maiorana, A., GREEN, D. J., & Hare, D. L. (2010) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2010.01.004 · Cited by 74
Effect of physical training on exercise capacity, gas exchange and N-terminal pro-brain natriuretic peptide levels in patients with chronic heart failure
Sarullo, F. M., Gristina, T., Brusca, I., Milia, S., Raimondi, R., Sajeva, M., Chiusa, S. M. L., Serio, G., Paterna, S., Pasquale, P. D., et al. (2006) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000238396.42718.61 · Cited by 71
The 2001 Canadian Cardiovascular Society consensus guideline update for the management and prevention of heart failure.
Liu, P. J., Arnold, M., Belenkie, I., Howlett, J. G., Huckell, V. F., Ignazewski, A., LeBlanc, M. H., McKelvie, R. S., Niznick, J., Parker, J. D., et al. (2001) · PubMed · Cited by 71
Long-term effect of social relationships on mortality in patients with congestive heart failure
Murberg, T. A. (2004) · The International Journal of Psychiatry in Medicine · doi:10.2190/gkj2-p8bd-v59x-mjnq · Cited by 68
Impact of exercise training on redox signaling in cardiovascular diseases
Campos, J. C., Gomes, M. K., & Ferreira, J. C. B. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.08.035 · Cited by 74
Six-Month Aerobic Exercise Training Ameliorates Central Sleep Apnea in Patients With Chronic Heart Failure
Yamamoto, U., Mohri, M., Shimada, K., Origuchi, H., Miyata, K., Ito, K., Abe, K., & Yamamoto, H. (2007) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2007.08.001 · Cited by 73
Measurement of Health-Related Quality of Life in Chronic Heart Failure, from a Nursing Perspective—a Review of the Literature
Johansson, P., Agnebrink, M., Dahlström, U., & Broström, A. (2004) · European Journal of Cardiovascular Nursing · doi:10.1016/j.ejcnurse.2003.09.004 · Cited by 70
Exercise training in heart failure: practical guidance
Conraads, V. M., & Beckers, P. J. (2010) · Heart · doi:10.1136/hrt.2009.183889 · Cited by 67
Impact of Gender on Benefits of Exercise Training on Sympathetic Nerve Activity and Muscle Blood Flow in Heart Failure
Antunes‐Correa, L. M., de Melo, R. C., Nobre, T. S., Ueno, L. M., Franco, F. G. M., Braga, A. M. W., Rondon, M. U. P. B., Brum, P. C., Barretto, A. C. P., Middlekauff, H. R., et al. (2009) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfp168 · Cited by 69
Determination of exercise training heart rate in patients on β-blockers after myocardial infarction
Tabet, J., Meurin, P., Driss, A. B., Thabut, G., Weber, H., Renaud, N., Odjinkem, N., & Solal, A. C. (2006) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000209813.05573.4d · Cited by 70
Depressive symptoms and mortality in patients with congestive heart failure: a six-year follow-up study.
Murberg, T. A., & Furze, G. (2004) · PubMed · Cited by 67
EFFECTS OF EXERCISE AND CARDIAC REHABILITATION ON CARDIOVASCULAR OUTCOMES
Ades, P. A., & Coello, C. E. (2000) · Medical Clinics of North America · doi:10.1016/s0025-7125(05)70217-0 · Cited by 66
Exercise Training and Sympathetic Regulation in Experimental Heart Failure
Zucker, I. H., Patel, K. P., Schultz, H. D., Li, Y.-F., Wang, W., & Pliquett, R. U. (2004) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200407000-00006 · Cited by 67
“The data from the studies described above demonstrate that exercise training of animals with experimental CHF results in: (1) a decrease in resting sympathetic outflow, (2) a normalization in cardiovascular reflex sensitivity, (3) a reduction in plasma angiotensin II, (4) a downregulation in AT1 receptors in the brain…”
BackgroundMethod
Effects of the Characteristics of Teaching on the Outcomes of Heart Failure Patient Education Interventions: A Systematic Review
Fredericks, S., Beanlands, H. J., Spalding, K., & Silva, M. D. (2009) · European Journal of Cardiovascular Nursing · doi:10.1016/j.ejcnurse.2009.08.002 · Cited by 69
Clinical Role of Exercise Training in the Management of Patients With Chronic Heart Failure
Keteyian, S. J., Piña, I. L., Hibner, B. A., & Fleg, J. L. (2010) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0b013e3181d0c1c1 · Cited by 66
Surgical Prehabilitation
Whittle, J., Wischmeyer, P. E., Grocott, M. P. W., & Miller, T. E. (2018) · Anesthesiology Clinics · doi:10.1016/j.anclin.2018.07.013 · Cited by 66
Exercise-induced changes in calcium handling in left ventricular cardiomyocytes
Kemi, O. J. (2007) · Frontiers in bioscience · doi:10.2741/2685 · Cited by 65
“Clinical studies have already demonstrated that regular exercise training is beneficial in cardiovascular disease patients and in those at risk of developing disease (91-94), and that the level of aerobic fitness predicts survival in healthy as well as in a cardiovascular disease population, even when other traditiona…”
Background
Insulin Signalling and Resistance in Patients with Chronic Heart Failure
Kemppainen, J., Tsuchida, H., Stolen, K. Q., Karlsson, H., Björnholm, M., Heinonen, O. J., Nuutila, P., Krook, A., Knuuti, J. M., & Zierath, J. R. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.042648 · Cited by 65
“Regular moderate exercise is known to improve quality of life, functional capacity, peripheral blood flow and muscular adaptations in patients with CHF (Magnusson et al. 1996; Hambrecht et al. 1997, 1998; Belardinelli et al. 1999).”
Background
Exercise Training for Heart Failure
Coats, A. J. S. (1999) · Circulation · doi:10.1161/01.cir.99.9.1138 · Cited by 65
Predictors of a sustained response to exercise training in patients with chronic heart failure: A telemonitoring study
Smart, N., Haluska, B., Jeffriess, L., & Marwick, T. H. (2005) · American Heart Journal · doi:10.1016/j.ahj.2005.01.035 · Cited by 64
Aerobic interval training attenuates remodelling and mitochondrial dysfunction in the post-infarction failing rat heart
Kraljević, J., Marinović, J., Pravdić, D., Maslov, P. Z., Dujić, Ž., Wisløff, U., & Ljubković, M. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt080 · Cited by 64
Mechanisms of exercise‐induced improvements in the contractile apparatus of the mammalian myocardium
Kemi, O. J., & Wisløff, U. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02132.x · Cited by 85
“…cardiac function, health and quality of life, and reduces morbidity and mortality to significant degrees in both sexes, in patients of all ages and at all stages of the disease (Paffenbarger et al. 1993, Blair et al. 1995, Belardinelli et al. 1999, Jolliffe et al. 2001, Gulati et al. 2003).”
Background
Long Non-Coding RNAs in Cardiovascular Diseases: Potential Function as Biomarkers and Therapeutic Targets of Exercise Training
Correia, C. C. M., Rodrigues, L. F., Pelozin, B. R. D. A., de Oliveira, E. M., & Fernandes, T. M. (2021) · Non-Coding RNA · doi:10.3390/ncrna7040065 · Cited by 64
The Comparative Effectiveness of Heart Disease Prevention and Treatment Strategies
Kottke, T. E., Faith, D., Jordan, C. O., Pronk, N. P., Thomas, R. J., & Capewell, S. (2008) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2008.09.010 · Cited by 61
Predictors of re-hospitalization in patients with chronic heart failure
Zaya, M. (2012) · World Journal of Cardiology · doi:10.4330/wjc.v4.i2.23 · Cited by 63
Deutsche Leitlinie zur Rehabilitation von Patienten mit Herz-Kreislauferkrankungen (DLL-KardReha)
Bjarnason‐Wehrens, B., Held, K., Hoberg, E., Karoff, M., & Rauch, B. (2007) · Clinical Research in Cardiology Supplements · doi:10.1007/s11789-007-0001-0 · Cited by 64
Changes in the Quality of Life: A Major Goal of Cardiac Rehabilitation
Shephard, R. J., & Franklin, B. A. (2001) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200107000-00001 · Cited by 62
Predictors of quality of life in patients with heart failure
Hwang, S., Liao, W., & Huang, T. (2013) · Japan Journal of Nursing Science · doi:10.1111/jjns.12034 · Cited by 61
Exercise training to improve health related quality of life in long term survivors of major burn injury: A matched controlled study
Grisbrook, T. L., Reid, S. L., Edgar, D. W., Wallman, K. E., Wood, F. M., & Elliott, C. M. (2012) · Burns · doi:10.1016/j.burns.2012.03.007 · Cited by 61
Physical exercise improves plasmatic levels of IL-10, left ventricular end-diastolic pressure, and muscle lipid peroxidation in chronic heart failure rats
Nunes, R. B., Tonetto, M. S., Machado, N., Chazan, M., Heck, T. G., da Veiga, A. B. G., & Lago, P. D. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00062.2008 · Cited by 60
“On the other hand, many studies have demonstrated that physical exercise is a powerful factor to improve peripheral function in CHF, both in humans (5, 22, 44) and in animal models (53), without increases in mortality.”
Background
Aerobic exercise training improves skeletal muscle function and Ca2+ handling-related protein expression in sympathetic hyperactivity-induced heart failure
Júnior, C. R. B., Ferreira, J. C. B., Pereira, M. G., Bacurau, A. V. N., & Brum, P. C. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00281.2010 · Cited by 61
Effects of exercise training started within 2 weeks after acute myocardial infarction on myocardial perfusion and left ventricular function: a gated SPECT imaging study
Giallauria, F., Acampa, W., Ricci, F., Vitelli, A., Maresca, L., Mancini, M. E., Grieco, A., Gallicchio, R., Xhoxhi, E., Spinelli, L., et al. (2011) · European Journal of Preventive Cardiology · doi:10.1177/1741826711425427 · Cited by 59
“Similarly, in chronic heart failure patients (n¼ 50, 45 men, mean age 56 7 years), Belardinelli et al.28 found that the percentage of both myocardial defects with increased thallium uptake was significantly higher after 2 months of exercise training in trained than in control patients.”
Background
Physical training in patients with chronic heart failure of ischemic origin: effect on exercise capacity and left ventricular remodeling
Klecha, A., Kawecka−Jaszcz, K., Bacior, B., Kubinyi, A., Pasowicz, M., Klimeczek, P., & Banyś, R. P. (2007) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3280114f12 · Cited by 61
Short-term impact of a 4-week intensive cardiac rehabilitation program on quality of life and anxiety-depression
Freitas, P. D., Haïda, A., Bousquet, M., Richard, L., Mauriège, P., & Guiraud, T. (2011) · Annals of Physical and Rehabilitation Medicine · doi:10.1016/j.rehab.2011.02.001 · Cited by 61
“, puis l’étude HF-Action ont montré que la qualité de vie des patients insuffisants cardiaques est améliorée par l’exercice lors d’une prise en charge en ambulatoire à moyen et long terme [4,10].”
Background
Cardiopulmonary Exercise Testing for Risk Prediction in Major Abdominal Surgery
Levett, D. Z. H., & Grocott, M. P. W. (2015) · Anesthesiology Clinics · doi:10.1016/j.anclin.2014.11.001 · Cited by 60
Home-based exercise improves the quality of life and physical function but not the psychological status of people with chronic heart failure: a randomised trial
Chien, C.-L., Lee, C., Wu, Y., & Wu, Y.-T. (2011) · Journal of physiotherapy · doi:10.1016/s1836-9553(11)70036-4 · Cited by 61
“Exercise training improved symptoms and quality of life in people with chronic heart failure in some studies investigating centre-based programs (Belardinelli et al 1999, McKelvie et al 2002, Rees et al 2004, van Tol et al 2006).”
Background
Exercise training restores aerobic capacity and energy transfer systems in heart failure treated with losartan
Kemi, O. J., Høydal, M. A., Haram, P. M., Garnier, A., Fortin, D., Ventura‐Clapier, R., & Ellingsen, Ø. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.06.008 · Cited by 60
T’ai Chi Exercise in Patients with Chronic Heart Failure
Yeh, G. Y., Wayne, P. M., & Phillips, R. S. (2008) · KARGER eBooks · doi:10.1159/000134300 · Cited by 59
Exercise training prevents the exaggerated exercise pressor reflex in rats with chronic heart failure
Wang, H., Pan, Y.-X., Wang, W.-Z., Gao, L., Zimmerman, M. C., Zucker, I. H., & Wang, W. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01273.2009 · Cited by 60
“However, over the past decade, numerous clinical trials and small randomized studies have demonstrated that long-term regular exercise is safe in stable CHF patients and increases the quality of life as well as survival (1, 18, 31, 54).”
Background
Increasing Lifestyle Physical Activity in Patients with Depression or Other Serious Mental Illness
Richardson, C. R., Avripas, S. A., NEAL, D. L., & Marcus, S. M. (2005) · Journal of Psychiatric Practice · doi:10.1097/00131746-200511000-00004 · Cited by 63
Efficacy and Safety of Exercise Training in Patients With Chronic Heart Failure
O’Connor, C. M., Whellan, D. J., Lee, K. L., Keteyian, S. J., Cooper, L. S., Ellis, S. J., Leifer, E., Kraus, W. E., Kitzman, D. W., Blumenthal, J. A., et al. (2017) · Cited by 60
Resistance Versus Aerobic Exercise Training in Chronic Heart Failure
Mandic, S., MYERS, J. N., Selig, S., & Levinger, I. (2011) · Current Heart Failure Reports · doi:10.1007/s11897-011-0078-0 · Cited by 61
Psychosocial Factors and Their Association with Clinical Outcomes in Patients with Heart Failure: Why Clinicians Do not Seem to Care
Moser, D. K. (2002) · European Journal of Cardiovascular Nursing · doi:10.1016/s1474-5151(02)00033-6 · Cited by 59
Guidelines for management of patients with chronic heart failure in Australia
Krum, H. (2001) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2001.tb143375.x · Cited by 59
Effect of aerobic and resistance exercise on central hemodynamic responses in severe chronic heart failure
Cheetham, C., Green, D., Collis, J., Dembo, L., & O'Driscoll, G. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01240.2001 · Cited by 58
Effect of outpatient exercise training programmes in patients with chronic heart failure: a systematic review
van der Meer, S., Zwerink, M., van Brussel, M., van der Valk, P., Wajon, E. M. C. J., & van der Palen, J. A. M. (2011) · European Journal of Preventive Cardiology · doi:10.1177/1741826711410516 · Cited by 59
Cardiac adaptation to endurance exercise in rats
Fenning, A. S., Harrison, G., Dwyer, D., Rose’Meyer, R. B., & Brown, L. (2003) · Springer eBooks · doi:10.1007/978-1-4419-9238-3_8 · Cited by 58
Heart Failure Patient Adherence
Corotto, P. S., McCarey, M. M., Adams, S., Khazanie, P., & Whellan, D. J. (2012) · Heart Failure Clinics · doi:10.1016/j.hfc.2012.09.004 · Cited by 58
A Systematic Review of the Effectiveness of Qigong Exercise in Cardiac Rehabilitation
Chan, C., Wang, C., Ho, R., Ho, A. H. Y., Ziea, E. T.-C., Wong, V. C.-W. T., & Ng, S. (2012) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x12500206 · Cited by 58
Tai Chi Enhances the Effects of Endurance Training in the Rehabilitation of Elderly Patients with Chronic Heart Failure
Caminiti, G., Volterrani, M., Marazzi, G., Cerrito, A., Massaro, R., Arisi, A., Franchini, A., Sposato, B., & Rosano, G. M. C. (2010) · Rehabilitation Research and Practice · doi:10.1155/2011/761958 · Cited by 58
“Hindawi Publishing Corporation Rehabilitation Research and Practice Volume 2011, Article ID 761958, 6 pages doi:10.1155/2011/761958”
Influential
Leitlinie körperliche Aktivität zur Sekundärprävention und Therapie kardiovaskulärer Erkrankungen
Bjarnason‐Wehrens, B., Schulz, O., Gielen, S., Halle, M., Dürsch, M., Hambrecht, R., Lowis, H., Kindermann, W., Schulze, R., & Rauch, B. (2009) · Clinical Research in Cardiology Supplements · doi:10.1007/s11789-009-0078-8 · Cited by 58
Effect of physical training on quality of life and oxygen consumption in patients with congestive heart failure
Klocek, M., Kubinyi, A., Bacior, B., & Kawecka−Jaszcz, K. (2005) · International Journal of Cardiology · doi:10.1016/j.ijcard.2004.10.021 · Cited by 58
Exercise intolerance in chronic heart failure: mechanisms and therapies. Part II
Piepoli, M. F., Guazzi, M., Boriani, G., Cicoira, M., Corrà, U., Libera, L. D., Emdin, M., Mele, D., Passino, C., Vescovo, G., et al. (2010) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e32833f3aa5 · Cited by 60
Outpatient-based physical rehabilitation for survivors of prolonged critical illness: A randomized controlled trial.
McWilliams, D. J., Benington, S., & Atkinson, D. (2016) · Physiotherapy Theory and Practice · doi:10.3109/09593985.2015.1137663 · Cited by 61
Pilates in Heart Failure Patients: A Randomized Controlled Pilot Trial
Guimarães, G. V., Carvalho, V. O., Bocchi, E. A., & d’Avila, V. M. (2011) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2011.00285.x · Cited by 57
Heart Failure Exercise And Training Camp: Effects of a multicomponent exercise training intervention in patients with heart failure
Pozehl, B., Duncan, K. A., Hertzog, M. A., & NORMAN, J. F. (2010) · Heart & Lung · doi:10.1016/j.hrtlng.2010.04.008 · Cited by 58
Predictors of Noncompliance to Exercise Training in Heart Failure
Corvera‐Tindel, T., Doering, L. V., Gómez, T., & Dracup, K. (2004) · The Journal of Cardiovascular Nursing · doi:10.1097/00005082-200407000-00006 · Cited by 55
Verbal Memory Impairment in Congestive Heart Failure
Incalzi, R. A., Trojano, L., Acanfora, D., Crisci, C., Tarantino, F., Abete, P., Rengo, F., & CHF Italian Study Investigators (2003) · Journal of Clinical and Experimental Neuropsychology · doi:10.1076/jcen.25.1.14.13635 · Cited by 57
Rehabilitación cardíaca en pacientes con infarto de miocardio. Resultados tras 10 años de seguimiento
Montero, J. M. M., Artigao, R., Durán, M. D. M., Zarzosa, C. D. P., & Abraira, V. (2005) · Revista Española de Cardiología · doi:10.1157/13079912 · Cited by 57
Relation of Physical Activity, Cardiac Function, Exercise Capacity, and Quality of Life in Patients With a Systemic Right Ventricle
Winter, M. M., Bouma, B. J., van Dijk, A. P. J., Groenink, M., Nieuwkerk, P. T., van der Plas, M. N., Sieswerda, G. T., Konings, T. C., & Mulder, B. J. M. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.06.053 · Cited by 57
Right Ventricular End-Diastolic Volume Combined With Peak Systolic Blood Pressure During Exercise Identifies Patients at Risk for Complications in Adults With a Systemic Right Ventricle
van der Bom, T., Winter, M. M., Groenink, M., Vliegen, H. W., Pieper, P. G., van Dijk, A. P. J., Sieswerda, G. T., Roos‐Hesselink, J. W., Zwinderman, A. H., Mulder, B. J. M., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.06.026 · Cited by 60
“Moreover, Belardinelli et al. (44,45) showed that, in addition to improved VO 2peak , exercise training also reduced clinical events in patients with acquired leftventricularheartfailure.”
Background
Impact of ‘‘Off-Label’’ Use of Ivabradine on Exercise Capacity, Gas Exchange, Functional Class, Quality of Life, and Neurohormonal Modulation in Patients With Ischemic Chronic Heart Failure
Sarullo, F. M., Fazio, G., Puccio, D., Fasullo, S., Paterna, S., Novo, S., & Pasquale, P. D. (2010) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248410370326 · Cited by 56
Exercise Training and Heart Failure: A Review of the Literature
Morris, J. H., & Chen, L. (2019) · Cardiac failure review · doi:10.15420/cfr.2018.31.1 · Cited by 59
Effects of Exercise Training on Myocardial Energy Metabolism and Ventricular Function Assessed by Quantitative Phosphorus-31 Magnetic Resonance Spectroscopy and Magnetic Resonance Imaging in Dilated Cardiomyopathy
Beer, M., Wagner, D., MYERS, J. N., Sandstede, J. J. W., Köstler, H., Hahn, D., Neubauer, S., & Dubach, P. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.09.075 · Cited by 58
Exercise Training for Heart Failure Patients Improves Respiratory Muscle Endurance, Exercise Tolerance, Breathlessness, and Quality of Life
McConnell, T. R., Mandak, J. S., Sykes, J. S., Fesniak, H., & Dasgupta, H. (2003) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200301000-00003 · Cited by 56
Exercise Intolerance in Pulmonary Arterial Hypertension
Fowler, R., Gain, K. R., & Gabbay, E. (2012) · Pulmonary Medicine · doi:10.1155/2012/359204 · Cited by 56
“Exercise training has well-established safety and efficacy for improving exercise capacity and QoL in chronic obstructive pulmonary disease (COPD) [6] and left heart failure (LHF) [7].”
BackgroundInfluential
Self-care Behaviors in Indigent Patients With Heart Failure
Macabasco‐O’Connell, A., Crawford, M. H., Stotts, N. A., Stewart, A. L., & Froelicher, E. S. (2008) · The Journal of Cardiovascular Nursing · doi:10.1097/01.jcn.0000317427.21716.5f · Cited by 56
Enhancement of heart rate variability by cholinergic stimulation with pyridostigmine in healthy subjects
da Nóbrega, A. C. L., dos Reis, A. F., Moraes, R. S., Bastos, B. G., Ferlin, E. L., & Ribeiro, J. P. (2001) · Clinical Autonomic Research · doi:10.1007/bf02317797 · Cited by 56
“In humans, regular aerobic exercise increases vagal tone, as evaluated by HRV, in patients after myocardial infarction [44] and with heart failure [45], an effect believed to contribute to the reduced mortality in these patients [46,47].”
Background
Effects of exercise-based cardiac rehabilitation in patients after percutaneous coronary intervention: A meta-analysis of randomized controlled trials
Yang, X., Li, Y., Ren, X., Xiong, X., Wu, L., Li, J., Wang, J., Gao, Y., Shang, H., & Xing, Y. (2017) · Scientific Reports · doi:10.1038/srep44789 · Cited by 55
Effects of a cardiac rehabilitation programme on plasma cardiac biomarkers in patients with chronic heart failure
Billebeau, G., Vodovar, N., Sadoune, M., Launay, J., Beauvais, F., & Solal, A. C. (2017) · European Journal of Preventive Cardiology · doi:10.1177/2047487317705488 · Cited by 55
“Taken together, these beneficial effects tend to improve the outcomes of CHF patients, although long-term physical exercise was proven to be difficult to sustain outside of supervised programmes.(3,10) Cardiac plasma biomarkers, mostly B-type natriuretic paptide (BNP) and cardiac troponin, are currently used for the d…”
Inter-individual variation in adaptations to endurance and resistance exercise training: genetic approaches towards understanding a complex phenotype
Vellers, H. L., Kleeberger, S. R., & Lightfoot, J. T. (2018) · Mammalian Genome · doi:10.1007/s00335-017-9732-5 · Cited by 56
The effect of physical training on workload, upper leg muscle function and muscle areas in patients with chronic heart failure
Senden, P. J., Sabelis, L. W. E., Zonderland, M. L., Hulzebos, E. H. J., Bol, E., & Mosterd, W. L. (2005) · International Journal of Cardiology · doi:10.1016/j.ijcard.2004.10.039 · Cited by 55
Device-Guided Paced Breathing in the Home Setting
Parati, G., Malfatto, G., Boarin, S., Branzi, G., Caldara, G., Giglio, A., Bilo, G., Ongaro, G., Alter, A., Gavish, B., et al. (2008) · Circulation Heart Failure · doi:10.1161/circheartfailure.108.772640 · Cited by 55

Authors: Belardinelli, R., Georgiou, D., Cianci, G., & Purcaro, A.
Affiliations: Columbia University (US)
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1999-03-09
Volume: 99
Issue: 9
Pages: 1173-1182
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.99.9.1173
OpenAlex: W2136315725
Cited by: 1,099
References: 25
Citations by year: 2026: 9 · 2025: 20 · 2024: 19 · 2023: 16 · 2022: 26 · 2021: 31 · 2020: 25 · 2019: 25 · 2018: 30 · 2017: 36 · 2016: 37 · 2015: 48 · 2014: 34 · 2013: 38 · 2012: 53
FWCI: 101.26
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords: chronic heart failure, exercise training, moderate-intensity aerobic training, functional capacity, peak oxygen uptake, quality of life, myocardial perfusion, thallium scintigraphy, mortality, hospital readmission, ischemic heart disease, ventilatory threshold, prognostic factors
MeSH terms: Aged, Echocardiography, Exercise Therapy, Female, Heart Failure, Hemodynamics, Humans, Male, Middle Aged, Myocardium, Patient Readmission, Prospective Studies, Quality of Life, Radionuclide Imaging, Thallium Radioisotopes, Multivariate Analysis, Survival Analysis, Treatment Outcome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Randomized, Controlled Trial of Long-Term Moderate Exercise Training in Chronic Heart Failure: Effects on Functional Capacity, Quality of Life, and Clinical Outcome

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks