The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Short- and Long-Term Changes in Plasma Inflammatory Markers Associated With Preeclampsia
Abstract
Preeclampsia is characterized by hypertension, dyslipidemia, and increased systemic inflammatory response and has been associated with an increased maternal risk of cardiovascular disease later in life. Low-grade chronic inflammation is a risk factor for cardiovascular disease. This study examined changes in inflammatory markers prospectively during pregnancy, the current inflammatory status of women who had a pregnancy complicated by preeclampsia 20 years previously against matched controls, and the association between inflammatory genes and risk of preeclampsia in a case (n=106) control (n=212) study. In control pregnancies (n=34), mean interleukin-10 (IL-10) levels increased 38% ( P =0.012) and tumor necrosis factor-α (TNF-α) by 33% ( P =0.024) between the first and third trimesters. The mean preeclampsia group IL-10 and TNF-α rose by 43% ( P =0.013 and P =0.0065, respectively) from the first to the third trimester. In women with preeclampsia only, plasma IL-6 increased from the first to the third trimester (1.66 [2.04] to 2.94 [2.47] pg/mL; P =0.0004). Twenty years after the index pregnancy, women who had had preeclampsia demonstrated significantly higher IL-6 to IL-10 ratio (3.96 [6.07] versus 2.12 [1.89]; P =0.034) compared with a healthy index pregnancy 20 years previously, that persisted after adjustment for smoking and current body mass index. The IL-1β (C-511T), IL-6 (G-174C), TNF-α (G-308A), E-selectin (S128R), intercellular adhesion molecule-1 (K469E), and C-reactive protein (C1059G) polymorphisms were not associated with risk of developing preeclampsia. In conclusion, preeclampsia is associated with short- and long-term changes in inflammatory status.
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Cites
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A major role for VCAM-1, but not ICAM-1, in early atherosclerosis
Cybulsky, M. I., Iiyama, K., Li, H., Zhu, S., Chen, M., Iiyama, M., Davis, V., Gutierrez-Ramos, J.-C., Connelly, P. W., & Milstone, D. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11871 · Cited by 1,217
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Cited by
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554
Rich-Edwards, J. W., Fraser, A., Lawlor, D. A., & Catov, J. M. (2014) · Epidemiologic Reviews · doi:10.1093/epirev/mxt006 · Cited by 417
Tosun, M., Celik, H., Avci, B., Yavuz, E., Alper, T., & Malatyalioğlu, E. (2010) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767051003774942 · Cited by 185
Obesity: a risk factor for preeclampsia
Walsh, S. W. (2007) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2007.09.003 · Cited by 155
Recent Progress Toward the Understanding of the Pathophysiology of Hypertension During Preeclampsia
LaMarca, B. D., Gilbert, J., & Granger, J. P. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.108837 · Cited by 142
Metadata
- Authors
- Freeman, D. J., McManus, F., Brown, E. A., Cherry, L., Norrie, J., Ramsay, J. E., Clark, P., Walker, I. D., Sattar, N., & Greer, I. A.
- Venue
- Hypertension
- Published
- 2004-11
- Volume
- 44
- Issue
- 5
- Pages
- 708-714
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2157663618
- Cited by
- 299
- References
- 44
- FWCI
- 11.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Freeman, D. J., McManus, F., Brown, E. A., Cherry, L., Norrie, J., Ramsay, J. E., Clark, P., Walker, I. D., Sattar, N., & Greer, I. A. (2004). Short- and Long-Term Changes in Plasma Inflammatory Markers Associated With Preeclampsia. Hypertension. https://doi.org/10.1161/01.hyp.0000143849.67254.ca
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