The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Fructose-induced insulin resistance and hypertension in rats.
Abstract
To determine if hypertension could be produced in normal rats by feeding them a fructose-enriched diet, Sprague-Dawley rats were fed either normal chow or a diet containing 66% fructose as a percentage of total calories for approximately 2 weeks. At the end of this period systolic blood pressure had increased from 124 +/- 2 to 145 +/- 2 (SEM) mm Hg in the fructose-fed rats, whereas no change occurred in the control group. In addition, hyperinsulinemia and hypertriglyceridemia were associated with hypertension in fructose-fed rats. The addition of clonidine to the drinking water inhibited fructose-induced hypertension, but not the increase in plasma insulin or triglyceride concentration seen in fructose-fed rats. Thus, the metabolic changes associated with fructose-induced hypertension are unlikely to be secondary to an increase in sympathetic activity. Whether or not this is also true of the hypertension remains to be clarified.
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Cites
Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.
Modan, M., Halkin, H., Almog, S., Lusky, A., Eshkol, A., Shefi, M., Shitrit, A., & Fuchs, Z. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111776 · Cited by 1,465
Effect of Insulin and Glucose Infusions on Sympathetic Nervous System Activity in Normal Man
Rowe, J. W., Young, J. B., Minaker, K. L., Stevens, A. L., Pallotta, J., & Landsberg, L. (1981) · Diabetes · doi:10.2337/diab.30.3.219 · Cited by 1,143
Cited by
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Self-citationReaven, G. M., Lithell, H., & Landsberg, L. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602083340607 · Cited by 1,435
Self-citationMetabolic Effects of Fructose and the Worldwide Increase in Obesity
Tappy, L., & Lê, K.-A. (2010) · Physiological Reviews · doi:10.1152/physrev.00019.2009 · Cited by 1,256
Te Morenga, L. A., Howatson, A. J., Jones, R. M., & Mann, J. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.081521 · Cited by 509
Scherrer, U., & Sartori, C. (1997) · Circulation · doi:10.1161/01.cir.96.11.4104 · Cited by 371
Metadata
- Authors
- Hwang, I. S., Ho, H., Hoffman, B. B., & Reaven, G. M.
- Venue
- Hypertension
- Published
- 1987-11
- Volume
- 10
- Issue
- 5
- Pages
- 512-516
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2167196393
- Cited by
- 889
- References
- 2
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hwang, I. S., Ho, H., Hoffman, B. B., & Reaven, G. M. (1987). Fructose-induced insulin resistance and hypertension in rats. Hypertension. https://doi.org/10.1161/01.hyp.10.5.512
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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