Effects of thyroid function on blood pressure. Recognition of hypothyroid hypertension.
Open accessAbstract
Hypothyroidism has been known to be associated, at times, with diastolic hypertension. We have found in 40 thyrotoxic patients that the induction of hypothyroidism by radioiodine therapy significantly increased diastolic blood pressure, raising it above 90 mm Hg in 16 (40%) of the patients. Restoration of euthyroidism with thyroxine administration significantly reduced the systolic and diastolic blood pressures in these patients, with a fall in diastolic pressure below 90 mm Hg in nine of 16 patients. The prevalence of hypothyroidism was determined by measurements of serum thyroxine and thyrotropin concentrations in 688 consecutive hypertensive patients, referred for evaluation and therapy of their hypertension. Hypothyroidism was found in 25 (3.6%) of the patients. Restoration of normal serum thyroxine and thyrotropin levels with thyroid hormone replacement therapy lowered diastolic blood pressure to levels below 90 mm Hg in 32% of these patients who could be followed up after withdrawal of all antihypertensive drug therapy when euthyroidism had been restored (i.e., 1.2% of the 688 patients). It is concluded that diastolic hypertension resulting from hypothyroidism is a relatively common disorder, present in 1.2% of our referred hypertensive patients, that should be sought and treated.
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The prevalence of hypothyroidism in the general nonselected hypertensive population is 3-4%.
“the consistent prevalence (3-4%) of hypothyroidism in the general nonselected hypertensive population (1,2,36)”
From The Role of Thyroid Hormone in Blood Pressure Homeostasis: Evidence from Short-Term Hypothyroidism in Humans (2002) · cites this paper as [36]
The Results report hypothyroidism in 25 of 688 hypertensive patients (3.6%), supporting the 3–4% figure for this study's patients. But these were patients referred for hypertension evaluation, and the authors explicitly say their prevalence cannot be taken to represent the entire hypertensive population. The claim's extension to a general, nonselected population is therefore unsupported. (LLM, conf=0.90)
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References 22 · Cited by 172
Research works printed but not linked: 22
- Thompson WO, Dickie LFN, Moms AE, Hilkevitch BH. The high incidence of hypertension in toxic goiteT and in myxe- dema. Endocrinology 1931; 15:265-272
- Fuller H Jr, Spittell JA Jr, McConahey WM, Schirger A. Myxedema and hypertension. Postgrad Med 1966;40:425-428
- Christensen NJ. Increased level of plasma noradrenaline in hypothyroidism. J Clin Endocrinol Metab 1972;35:359-363
- Bing RF, Briggs RSJ, Burden AC, Russell GI, Swales JD, Thurston H. Reversible hypertension and hypothyroidism. Clin Endocrinol 1980;13:339-342
- Menof P. The thyroid and atherosclerotic arterial disease. S AfrMedJ 1973;47:2315-2325
- Menof P. Essential hypertension: its control by new method. S AfrMedJ 1950;24:172-18O
- EndoT, Komiyal.TsykuiT, etal. Re-evaluation of a possible high incidence of hypertension in hypothyroid patients: plasma renin activity and aldosterone concentration of patients with hyperthyroidism and hypothyroidism. Endocrinol Jpn 1973; 20:433^*38
- Streeten DHP, Anderson GH Jr, Chiang R, Smulyan H. Preva- lence and pathogenic significance of hypothyroidisra in essen- tial hypertension [Abstract 2463]. In: Proceedings of the 7th international Congress of Endocrinology, Quebec City. Am- sterdam: Excerpta Medica, 1984
- Streeten DHP, Anderson GH Jr. Outpatient experience with saralasin. Kidney Int 1979;15:S44-S52
- Streeten DHP, Tomycz N, Anderson GH Jr. Reliability of screening methods for the diagnosis of primary aldosteronism. Am J Med 1979;67:403-413
- Ingbar SH. The thyroid gland. In: Wilson JD, Foster DW, eds. Williams textbook of endocrinology. 7th ed. Philadelphia: Saunders, 1985:783
- Anderson GHJr, Streeten DHP, DalakosTG. Pressor response to l-sar-8-ala-angiotensin II (saralasin) in hypertensive sub- jects. Ore Res 1977;40:243-250
- Bouhnik J, Galen F-X, Clauser E, Menard J, Corvol P. The renin-angiotensin system in thyroidectomized rats. Endocri- nology 1981;108:647-650
- Aikawa JK. The nature of myxedema-alterations in serum elec- trolyte concentrations and radiosodium space and in exchange- able sodium and potassium content. Ann Intem Med 1956; 44:30-39
- Waters AK. Body water compartments and exchangeable body sodium in hypothyroidism. J Nucl Med Allied Sci 1978;22:43- 45
- Wiswell JG, Hurwitz GE, Coronho V, Bing OHL, Child DL. Urinary catecholamines and their metabolites in hyperthyroid- ism and hypothyroidism. J Clin Endocrinol Metab 1963;23: 1102-1106
- Christensen NJ. Plasma noradrenaline and adrenaline in pa- tients with thyrotoxicosis and myxoedema. Clin Sci Mol Med 1973;45:163-171
- Schneckloth RE, Kurland GS, Freedberg AS. Effect of vari- ation in thyroid function on the pressor response to norepineph- rine in man. Metabolism 1953;2:546-555
- Fregly MJ. Thyroid activity of spontaneously hypertensive rats. Proc Soc Exp Biol Med 1975;149:124-132
- Fregly MJ, Baker MI, Gennaro JF Jr. Comparison of effects of thyroidectomy with propylthiouracil treatment on renal hyper- tension in rats. Am J Physiol 1960; 198:4-12
- Fregly MJ. Prevention of salt hypertension by propylthiouracil treatment in rats. Proc Soc Exp Biol Med 1959;102:299-302
- Rioux F, Berkowitz BA. Role of the thyroid gland in the development and maintenance of spontaneous hypertension in rats. Circ Res 1977;40:306-312
- Authors
- Streeten, D. H., Anderson, G. H., Howland, T., Chiang, R., & Smulyan, H.
- Affiliations
- SUNY Upstate Medical University (US)
- Venue
- Hypertension
- Published
- 1988-01
- Volume
- 11
- Issue
- 1
- Pages
- 78-83
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2146641576
- Cited by
- 172
- References
- 22
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 5 · 2019: 1 · 2018: 7 · 2017: 3 · 2016: 14 · 2015: 8 · 2014: 8 · 2013: 5 · 2012: 9
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-26748)
- National Center for Research Resources (RR229)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- hypothyroidism, diastolic hypertension, thyroid function, blood pressure, thyrotoxicosis, thyroxine replacement, serum thyroxine, thyroid-stimulating hormone, hypertensive patients, antithyroid drugs
- MeSH terms
- Adult, Aged, Blood Pressure Determination, Female, Humans, Hypertension, Hyperthyroidism, Hypothyroidism, Male, Middle Aged, Thyrotropin, Thyroxine
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