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Angiotensin I converting enzyme and the changes in our concepts through the years. Lewis K. Dahl memorial lecture.
Open accessAbstract
Changes in our concepts of angiotensin I converting enzyme are reviewed briefly. The actions of this enzyme go beyond liberating angiotensin II from angiotensin I or inactivating bradykinin. Its very wide distribution in the body and its activity in vitro indicate involvement in the metabolism of other biologically active peptides. The recent molecular cloning of the human enzyme confirmed the existence of a hydrophobic C-terminal peptide that forms the short transmembrane domain of this plasma membrane-bound enzyme. The much longer external portion contains two homologous active site domains but probably only one functional active center. Finally, in spite of the great progress made in studying angiotensin converting enzyme, there are many challenging problems waiting to be solved.
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Cambien, F., Poirier, O., Lecerf, L., Evans, A., Cambou, J.-P., Arveiler, D., Luc, G., Bard, J.-M., Bara, L., Ricard, S., et al. (1992) · Nature · doi:10.1038/359641a0 · Cited by 1,913
Regulation of Intrarenal Angiotensin II in Hypertension
Navar, L. G., Harrison-Bernard, L. M., Nishiyama, A., & Kobori, H. (2002) · Hypertension · doi:10.1161/hy0202.103821 · Cited by 375
[18] Peptidyl dipeptidase A: Angiotensin I-converting enzyme
Corvol, P., Williams, T. A., & Soubrier, F. (1995) · Methods in Enzymology · doi:10.1016/0076-6879(95)48020-x · Cited by 277
ACE Inhibitor???Induced Angioedema: Incidence, Prevention and Management
Vleeming, W., van Amsterdam, J. G. C., Stricker, B. H., & de Wildt, D. J. (1998) · Drug Safety · doi:10.2165/00002018-199818030-00003 · Cited by 243
Metadata
- Authors
- Erdös, E. G.
- Venue
- Hypertension
- Published
- 1990-10
- Volume
- 16
- Issue
- 4
- Pages
- 363-370
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2041670760
- Cited by
- 412
- References
- 0
- FWCI
- 10.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Erdös, E. G. (1990). Angiotensin I converting enzyme and the changes in our concepts through the years. Lewis K. Dahl memorial lecture. Hypertension. https://doi.org/10.1161/01.hyp.16.4.363
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