Muscle sympathetic nerve activity in renovascular hypertension and primary aldosteronism.
Abstract
Previous studies, including our own, have demonstrated that muscle sympathetic nerve activity (MSNA) is increased in patients with essential hypertension compared with normotensive subjects. However, the features of sympathetic nerve activity are still unknown in secondary hypertension. We examined MSNA in eight patients with renovascular hypertension and in 11 patients with primary aldosteronism. Twenty patients with essential hypertension and 20 normotensive subjects who were age-matched to the patients with renovascular hypertension and those with primary aldosteronism were also studied. The MSNA of a bundle of the tibial nerve was recorded by microneurography in supine subjects and expressed as both burst rate (bursts/min) and burst incidence (bursts/100 heart beats). Plasma renin activity and the plasma concentration of angiotensin II and aldosterone were also measured. MSNA was increased in the patients with renovascular hypertension compared with the patients with primary aldosteronism and those with essential hypertension and the normotensive subjects (p less than 0.01 for each). MSNA was decreased in the patients with primary aldosteronism compared with those with essential hypertension (p less than 0.01), and it was smaller than in the normotensive subjects (p less than 0.1). Furthermore, MSNA, plasma renin activity, and the plasma concentration of angiotensin II decreased significantly in five patients with renovascular hypertension 4-10 days after successful percutaneous renal angioplasty. Thus, the changes in MSNA seem to characterize the pathophysiology of renovascular hypertension and primary aldosteronism. Activation of the renin-angiotensin system may be involved in the increase in the central outflow of sympathetic nerve activity, thus exacerbating hypertension in patients with renovascular hypertension.
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Some studies have reported that patients with hypertension secondary to renal artery stenosis or primary aldosteronism display an increase in sympathetic nerve traffic to skeletal muscle circulation.
“Some studies have reported that patients with hypertension secondary to renal artery stenosis or primary aldosteronism also display an increase in sympathetic nerve traffic to skeletal muscle circulation54–56.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [54]
Other microneurographic studies failed to show an increase in sympathetic nerve traffic in hypertension secondary to renal artery stenosis or primary aldosteronism.
“In contrast, other microneurographic studies failed to show an increase in sympathetic nerve traffic in these forms of secondary hypertension38,54.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [54]
The results obtained from MSNA recordings in this study were similar to those previously published in age-comparable hypertensive subjects.
“The results obtained from MSNA recordings in this study were similar to those previously published in age-comparable hypertensive subjects (15,16,25,26,28).”
From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [28]
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References 22 · Cited by 163
- Authors
- Miyajima, E., Yamada, Y., Yoshida, Y., Matsukawa, T., Shionoiri, H., Tochikubo, O., & Ishii, M.
- Affiliations
- Yokohama City University (JP)
- Venue
- Hypertension
- Published
- 1991-06
- Volume
- 17
- Issue
- 6_pt_2
- Pages
- 1057-1062
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W1976289196
- Cited by
- 163
- References
- 22
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 11 · 2014: 7 · 2013: 7 · 2012: 10
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal and Vascular Pathologies
- Keywords
- muscle sympathetic nerve activity, renovascular hypertension, primary aldosteronism, essential hypertension, sympathetic nervous system, renin-angiotensin system, plasma renin activity, angiotensin II, aldosterone, tibial nerve
- MeSH terms
- Adolescent, Adult, Angiography, Angioplasty, Balloon, Angiotensin II, Humans, Hyperaldosteronism, Hypertension, Renovascular, Middle Aged, Muscles, Reference Values, Renal Circulation, Renin, Sympathetic Nervous System
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