Relation of obesity and gender to left ventricular hypertrophy in normotensive and hypertensive adults.
Open accessAbstract
Although it is recognized that both hypertension and obesity are associated with increased left ventricular mass, the relative impacts of obesity, arterial hypertension, and gender on the prevalence of ventricular hypertrophy remain uncertain. Accordingly, echocardiographic left ventricular mass normalized for height to the power of the allometric or growth relation between ventricular mass and height was compared in 164 normotensive subjects (85 men [24 obese] and 79 women [28 obese], aged 45 +/- 12 years) and 475 hypertensive patients (325 men [126 obese] and 150 women [85 obese], aged 54 +/- 10 years) from an adult employed population. Gender-specific upper normal limits were used to identify ventricular hypertrophy. Left ventricular mass/height 2.7 was higher in obese than normal-weight normotensive subjects (P < .004) independently of the level of blood pressure and identified a higher prevalence of hypertrophy (mainly eccentric) in obese than in normal-weight normotensive subjects (14% versus 5%, P < .04), a difference that was not detected by left ventricular mass/body surface area. Left ventricular mass/height identified hypertrophy in 52% of obese and 30% of normal-weight hypertensive patients (P < .0001) because of higher prevalences in obese than normal-weight patients of both eccentric (34% versus 20%) and concentric ventricular hypertrophy (18% versus 10%). The increase in left ventricular mass was independent of blood pressure values in obese normotensive women (but not men), and the prevalence of supranormal left ventricular mass/height 2.7 was even higher in hypertensive obese women (58%) than men (49%).(ABSTRACT TRUNCATED AT 250 WORDS)
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In significant obesity, LV weight/BSA is often normal or lower than normal because BSA increases more than LV weight.
“However, in the setting of significant obesity, LV weight/BSA is often normal or lower than normal because BSA increases more than LV weight (72, 73, 197).”
From Cardiac remodeling in obesity (2008) · cites this paper as [72]
Many published studies have concluded that obesity is independently associated with LV hypertrophy.
“Many published studies have concluded that obesity is independently associated with LV hypertrophy (22, 28, 63, 72, 116, 235, 242, 266, 279, 284, 377).”
From Cardiac remodeling in obesity (2008) · cites this paper as [72]
Several studies have shown synergistic effects between increasing BMI and increasing systolic blood pressure.
“Several studies have shown synergistic effects between increasing BMI and increasing systolic blood pressure (22, 72).”
From Cardiac remodeling in obesity (2008) · cites this paper as [72]
Multiple recent studies have shown a predominance of concentric geometry in obese patients.
“Unfortunately, this relatively straightforward and logical hypothesis is complicated by the fact that multiple recent studies have shown a predominance of concentric geometry in obese patients (22, 63, 72, 279, 377).”
From Cardiac remodeling in obesity (2008) · cites this paper as [72]
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References 30 · Cited by 391
Research works printed but not linked: 4
- National Institutes of.Health Consensus Development Panel on the Health Implications of Obesity. Health Implications of Obesity. Ann Intern Med 1985;103:1073-1077.
- Devereux RB. Evaluation of cardiac structure and function by echo- cardiography and other noninvasive techniques. In: Laragh JH, Brenner BM, eds. Hypertension: Pathophysiology, Diagnosis, Treatment. New York, NY: Raven Press Publishers; 1990:1479-1492.
- de Simone G, Devereux RB, Daniels SR, Meyer RA. Left ven- tricular mass in children and adults: differences in the allometric relations with body size. Clin Res. 1993;41:620A.
- de Simone G, Devereux RB. Hemorheologic abnormalities in obesity: hemodynamic and prognostic implications. Nutr Metab Cardiovasc Dis. 1992;2:185-190.
- Authors
- de Simone, G., Devereux, R. B., Roman, M. J., Alderman, M. H., & Laragh, J. H.
- Affiliations
- Division of Cardiology, New York Hospital-Cornell Medical Center, NY 10021.
- Venue
- Hypertension
- Published
- 1994-05
- Volume
- 23
- Issue
- 5
- Pages
- 600-606
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2057700688
- Cited by
- 391
- References
- 30
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 5 · 2023: 8 · 2022: 1 · 2021: 6 · 2020: 7 · 2019: 4 · 2018: 12 · 2017: 16 · 2016: 13 · 2015: 12 · 2014: 12 · 2013: 14 · 2012: 12
- FWCI
- 9.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2p50hl018323-17)
- National Heart, Lung, and Blood Institute (HL18323)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- obesity, left ventricular hypertrophy, sex differences, left ventricular mass, eccentric hypertrophy, concentric hypertrophy, normotensive subjects, echocardiography
- MeSH terms
- Adult, Aged, Body Weight, Female, Humans, Hypertension, Male, Middle Aged, Obesity, Regression Analysis, Sex Factors, Hypertrophy, Left Ventricular
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