Sympathetic outflow to muscles during treatment of hypertension with metoprolol
Open accessAbstract
Microelectrode recordings of multiunit sympathetic vasoconstrictor activity were made in muscle branches of the peroneal nerve in patients with essential hypertension before and during long-term treatment with the cardioselective beta-adrenergic receptor antagonist metoprolol. Nerve activity was quantified by counting the number of sympathetic bursts in the mean voltage neurogram. Metoprolol treatment lowered blood pressure and heart rate in all subjects. During long-term treatment, nerve activity was reduced both when compared to the level of activity after the first dose of the drug (p less than 0.01) and when compared to the control level before treatment (p less than 0.05). It is suggested that the reduction of sympathetic vasoconstrictor outflow to muscles contributed to the blood pressure reduction.
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The increased sympathetic activity in EHT+LVH was not attributable to antihypertensive treatment.
“Therefore, the increased activity in EHT + LVH was not attributable to antihypertensive treatment and, in fact, was still apparent despite the use of agents”
From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [30]
Chronic administration of atenolol or metoprolol may have either no effect on or reduce the resting mean frequency of sympathetic discharge in essential hypertension.
“However, chronic administration, as in this study, with agents such as atenolol (29)and metoprolol (30)may, respectively, have either no effect on or reduce the resting mean frequency of sympathetic discharge in EHT.”
From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [30]
Although an effect of medications in the two hypertensive groups cannot be completely excluded, they could not have entirely caused the excessive sympathetic hyperactivity.
“Therefore, although we cannot completely exclude an effect of medications in our 2 hypertensive groups, they could not have entirely caused the excessive sympathetic hyperactivity.”
From Sympathetic Neural Activation in Nondiabetic Metabolic Syndrome and Its Further Augmentation by Hypertension (2004) · cites this paper as [24]
β-blockers may have no effect or decrease MSNA in hypertensive patients.
“Although we cannot entirely exclude some influence of these agents, it is known in hypertensive patients that chronic ACE inhibitor therapy does not affect MSNA levels, 22 ARBs may decrease it, 23 and -blockers may have no effect or decrease MSNA.24,25”
From Sympathetic Neural Activation in Nondiabetic Metabolic Syndrome and Its Further Augmentation by Hypertension (2004) · cites this paper as [24]
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References 18 · Cited by 86
- Authors
- Wallin, B. G., Sundlöf, G., Strömgren, E., & Aberg, H.
- Venue
- Hypertension
- Published
- 1984-07
- Volume
- 6
- Issue
- 4
- Pages
- 557-562
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2076073800
- Cited by
- 86
- References
- 18
- Citations by year
- 2025: 2 · 2021: 1 · 2019: 1 · 2018: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- metoprolol, essential hypertension, peroneal nerve, beta-blockers, blood pressure reduction, heart rate reduction, microelectrode recording
- MeSH terms
- Adult, Blood Pressure, Female, Heart Rate, Humans, Hypertension, Male, Metoprolol, Microelectrodes, Middle Aged, Muscles, Norepinephrine, Renin, Sympathetic Nervous System
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