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Angiotensin increases inositol trisphosphate and calcium in vascular smooth muscle.
Open accessAbstract
Angiotensin II stimulated the breakdown of phosphatidylinositol-4,5-bisphosphate (PIP2) and the generation of inositol trisphosphate (IP3) in cultured rat aortic smooth muscle cells. The decrease in PIP2 and increase in IP3 levels were rapid (measurable at 5 seconds; maximum IP3 levels at 15 seconds). The time course of these changes was comparable to that of angiotensin II-induced increases in cytosolic free calcium, as measured by the calcium-sensitive fluorescent indicator quin 2. The IP3 formation was not stimulated by the calcium ionophore A23187 (5 microM), nor were angiotensin II-induced changes in IP3 formation inhibited by the removal of extracellular calcium with EGTA. Angiotensin II appears to be capable of generating more IP3 than is required for maximal release of intracellular calcium. These data are consistent with the hypothesis that generation of IP3 plays a role in the angiotensin II-induced mobilization of calcium from intracellular storage sites in vascular smooth muscle cells.
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Cited by
Identification of angiotensin II receptor subtypes
Chiu, A. T., Herblin, W. F., McCall, D. E., Ardecky, R. J., Carini, D. J., Duncia, J. V., Pease, L. J., Wong, P. C., Wexler, R. R., Johnson, A. L., et al. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)91054-1 · Cited by 819
Role of Angiotensin and Oxidative Stress in Essential Hypertension
Romero, J. C., & Reckelhoff, J. F. (1999) · Hypertension · doi:10.1161/01.hyp.34.4.943 · Cited by 358
K depletion alters angiotensin II receptor expression in vascular smooth muscle cells
Linas, S. L., Marzec-Calvert, R., & Ullian, M. E. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.258.5.c849 · Cited by 58
Metadata
- Authors
- Alexander, R. W., Brock, T. A., Gimbrone, M. A., & Rittenhouse, S. E.
- Venue
- Hypertension
- Published
- 1985-05
- Volume
- 7
- Issue
- 3_pt_1
- Pages
- 447-451
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2046649233
- Cited by
- 253
- References
- 0
- FWCI
- 21.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Alexander, R. W., Brock, T. A., Gimbrone, M. A., & Rittenhouse, S. E. (1985). Angiotensin increases inositol trisphosphate and calcium in vascular smooth muscle. Hypertension. https://doi.org/10.1161/01.hyp.7.3.447
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