Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases: Structure, Function, and Biochemistry
Open accessAbstract
Matrix metalloproteinases (MMPs), also designated matrixins, hydrolyze components of the extracellular matrix. These proteinases play a central role in many biological processes, such as embryogenesis, normal tissue remodeling, wound healing, and angiogenesis, and in diseases such as atheroma, arthritis, cancer, and tissue ulceration. Currently 23 MMP genes have been identified in humans, and most are multidomain proteins. This review describes the members of the matrixin family and discusses substrate specificity, domain structure and function, the activation of proMMPs, the regulation of matrixin activity by tissue inhibitors of metalloproteinases, and their pathophysiological implication.
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MMPs are important enzymes capable of hydrolyzing components, playing a critical role in ECM maintenance and various physiological processes.
“Within the ECM, matrix metalloproteases (MMPs) are important enzymes that are capable of hydrolyzing components, hereby playing a critical role in ECM maintenance and various other physiological processes.”
From Unraveling and Harnessing the Immune Response at the Cell–Biomaterial Interface for Tissue Engineering Purposes (2024) · cites this paper as [254]
TIMPs are specific inhibitors that bind MMPs in a 1:1 ratio and directly determine the level of MMP activity.
“Tissue inhibitors of metalloproteinases (TIMPs) are specific inhibitors that bind MMPs in a 1:1 ratio and directly determine the level of MMP activity.[139]”
From Foreign body reaction to biomaterials (2008) · cites this paper as [139]
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References 199 · Cited by 4,575
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- Authors
- Visse, R., & Nagase, H.
- Affiliations
- Imperial College London (GB)
- ORCID
- Nagase, Hideaki
- Venue
- Circulation Research
- Published
- 2003-05-02
- Volume
- 92
- Issue
- 8
- Pages
- 827-839
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2154401382
- Cited by
- 4,575
- References
- 199
- Citations by year
- 2026: 123 · 2025: 126 · 2024: 142 · 2023: 171 · 2022: 187 · 2021: 195 · 2020: 207 · 2019: 181 · 2018: 167 · 2017: 219 · 2016: 213 · 2015: 276 · 2014: 281 · 2013: 271 · 2012: 253
- FWCI
- 15.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Circulation Research
- Funders
- Wellcome Trust (057508)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- matrix metalloproteinases, tissue inhibitors of metalloproteinases, extracellular matrix degradation, MMP activation, substrate specificity, tissue remodeling, angiogenesis, wound healing, atherosclerotic plaque, arthritis, cancer
- MeSH terms
- Chromosome Mapping, Enzyme Precursors, Multigene Family, Humans, Models, Molecular, Protein Conformation, Tissue Inhibitor of Metalloproteinases, Matrix Metalloproteinases
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