The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Elevated Sarcoplasmic Reticulum Ca 2+ Leak in Intact Ventricular Myocytes From Rabbits in Heart Failure
Abstract
Altered sarcoplasmic reticulum (SR) Ca 2+ -ATPase and Na + -Ca 2+ exchange (NCX) function have been implicated in depressing SR Ca 2+ content and contractile function in heart failure (HF). Enhanced diastolic ryanodine receptor (RyR) leak could also lower SR Ca 2+ load in HF, but direct cellular measurements are lacking. In this study, we measure SR Ca 2+ leak directly in intact isolated rabbit ventricular myocytes from a well-developed nonischemic HF model. Abrupt block of SR Ca 2+ leak by tetracaine shifts Ca 2+ from the cytosol to SR. The tetracaine-induced decline in [Ca 2+ ] i and increase total SR Ca 2+ load ([Ca 2+ ] SRT ) directly indicate the SR Ca 2+ leak (before tetracaine). Diastolic SR Ca 2+ leak increases with [Ca 2+ ] SRT , and for any [Ca 2+ ] SRT is greater in HF versus control. Mathematical modeling was used to compare the relative impact of alterations in SR Ca 2+ leak, SR Ca 2+ -ATPase, and Na + -Ca 2+ exchange on SR Ca 2+ load in HF. We conclude that increased diastolic SR Ca 2+ leak in HF may contribute to reductions in SR Ca 2+ content, but changes in NCX in this HF model have more impact on [Ca 2+ ] SRT .
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Cites
PKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor)
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Excitation-Contraction Coupling and Cardiac Contractile Force
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Self-citationExcitation-Contraction Coupling and Cardiac Contractile Force
Bers, D. M. (2001) · Developments in Cardiovascular Medicine · doi:10.1007/978-94-010-0658-3 · Cited by 1,548
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Self-citationFractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes
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Self-citationCellular basis of abnormal calcium transients of failing human ventricular myocytes
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Cited by
Cardiac excitation–contraction coupling
Bers, D. M. (2002) · Nature · doi:10.1038/415198a · Cited by 4,744
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Self-citationLehnart, S. E., Wehrens, X. H. T., Reiken, S., Warrier, S., Belevych, A. E., Harvey, R. D., Richter, W., Jin, S.-L. C., Conti, M., & Marks, A. R. (2005) · Cell · doi:10.1016/j.cell.2005.07.030 · Cited by 517
Jiang, D., Xiao, B., Yang, D., Wang, R., Choi, P., Zhang, L., Cheng, H., & Chen, S. R. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402388101 · Cited by 440
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Metadata
- Authors
- Shannon, T. R., Pogwizd, S. M., & Bers, D. M.
- Venue
- Circulation Research
- Published
- 2003-10-03
- Volume
- 93
- Issue
- 7
- Pages
- 592-594
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2127952198
- Cited by
- 310
- References
- 24
- FWCI
- 9.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shannon, T. R., Pogwizd, S. M., & Bers, D. M. (2003). Elevated Sarcoplasmic Reticulum Ca 2+ Leak in Intact Ventricular Myocytes From Rabbits in Heart Failure. Circulation Research. https://doi.org/10.1161/01.res.0000093399.11734.b3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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