The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Pulmonary Hypertension in Transgenic Mice Expressing a Dominant-Negative BMPRII Gene in Smooth Muscle
Abstract
Bone morphogenetic peptides (BMPs), a family of cytokines critical to normal development, were recently implicated in the pathogenesis of familial pulmonary arterial hypertension. The type-II receptor (BMPRII) is required for recognition of all BMPs, and targeted deletion of BMPRII in mice results in fetal lethality before gastrulation. To overcome this limitation and study the role of BMP signaling in postnatal vascular disease, we constructed a smooth muscle–specific transgenic mouse expressing a dominant-negative BMPRII under control of the tetracycline gene switch (SM22-tet-BMPRII delx4+ mice). When the mutation was activated after birth, mice developed increased pulmonary artery pressure, RV/LV+S ratio, and pulmonary arterial muscularization with no increase in systemic arterial pressure. Studies with SM22-tet-BMPRII delx4+ mice support the hypothesis that loss of BMPRII signaling in smooth muscle is sufficient to produce the pulmonary hypertensive phenotype.
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Lane, K. B., Machado, R. D., Pauciulo, M. W., Thomson, J. R., Phillips, J. A., Loyd, J. E., Nichols, W. C., & Trembath, R. C. (2000) · Nature Genetics · doi:10.1038/79226 · Cited by 1,495
Self-citationDeng, Z., Morse, J. H., Slager, S. L., Cuervo, N., Moore, K. J., Venetos, G., Kalachikov, S., Cayanis, E., Fischer, S. G., Barst, R. J., et al. (2000) · The American Journal of Human Genetics · doi:10.1086/303059 · Cited by 1,206
TARASEVICIENE‐STEWART, L., KASAHARA, Y., ALGER, L., HIRTH, P., MAHON, G. M., WALTENBERGER, J., VOELKEL, N. F., & TUDER, R. M. (2001) · The FASEB Journal · doi:10.1096/fj.00-0343com · Cited by 817
Self-citationDoxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.
Kistner, A., Gossen, M., Zimmermann, F., Jerecic, J., Ullmer, C., Lübbert, H., & Bujard, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.10933 · Cited by 778
Thomson, J. R., Machado, R. D., Pauciulo, M. W., Morgan, N. V., Humbert, M., Elliott, G. C., Ward, K., Yacoub, M., Mikhail, G., Rogers, P., et al. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.10.741 · Cited by 732
Atkinson, C., Stewart, S., Upton, P. D., Machado, R., Thomson, J. R., Trembath, R. C., & Morrell, N. W. (2002) · Circulation · doi:10.1161/01.cir.0000012754.72951.3d · Cited by 697
Jonk, L. J. C., Itoh, S., Heldin, C.-H., ten Dijke, P., & Kruijer, W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.33.21145 · Cited by 568
BMPR2 Haploinsufficiency as the Inherited Molecular Mechanism for Primary Pulmonary Hypertension
Machado, R. D., Pauciulo, M. W., Thomson, J. R., Lane, K. B., Morgan, N. V., Wheeler, L., Phillips III, J. A., Newman, J., Williams, D., Galiè, N., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/316947 · Cited by 535
Self-citationPrimary pulmonary hypertension
Runo, J. R., & Loyd, J. E. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13167-4 · Cited by 521
Bellusci, S., Henderson, R., Winnier, G., Oikawa, T., & Hogan, B. L. M. (1996) · Development · doi:10.1242/dev.122.6.1693 · Cited by 483
Cited by
ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension
McLaughlin, V. V., Archer, S. L., Badesch, D. B., Barst, R. J., Farber, H. W., Lindner, J. R., Mathier, M. A., McGoon, M. D., Park, M. H., Rosenson, R. S., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.01.004 · Cited by 2,360
Cellular and Molecular Basis of Pulmonary Arterial Hypertension
Morrell, N. W., Adnot, S., Archer, S. L., Dupuis, J., Lloyd Jones, P., MacLean, M. R., McMurtry, I. F., Stenmark, K. R., Thistlethwaite, P. A., Weissmann, N., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.04.018 · Cited by 819
Stenmark, K. R., Meyrick, B., Galie, N., Mooi, W. J., & McMurtry, I. F. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00217.2009 · Cited by 774
Interleukin-6 Overexpression Induces Pulmonary Hypertension
Steiner, M. K., Syrkina, O. L., Kolliputi, N., Mark, E. J., Hales, C. A., & Waxman, A. B. (2009) · Circulation Research · doi:10.1161/circresaha.108.182014 · Cited by 655
TGF-β signaling in vascular biology and dysfunction
Goumans, M.-J., Liu, Z., & ten Dijke, P. (2009) · Cell Research · doi:10.1038/cr.2008.326 · Cited by 601
Metadata
- Authors
- West, J., Fagan, K., Steudel, W., Fouty, B., Lane, K., Harral, J., Hoedt-Miller, M., Tada, Y., Ozimek, J., Tuder, R., & Rodman, D. M.
- Venue
- Circulation Research
- Published
- 2004-04-30
- Volume
- 94
- Issue
- 8
- Pages
- 1109-1114
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2171273257
- Cited by
- 263
- References
- 20
- FWCI
- 15.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Pulmonary Hypertension in Transgenic Mice Expressing a Dominant-Negative BMPRII Gene in Smooth Muscle. https://app.cochat.ai/papers/10.1161/01.res.0000126047.82846.20
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- West, J., Fagan, K., Steudel, W., Fouty, B., Lane, K., Harral, J., Hoedt-Miller, M., Tada, Y., Ozimek, J., Tuder, R., & Rodman, D. M. (2004). Pulmonary Hypertension in Transgenic Mice Expressing a Dominant-Negative BMPRII Gene in Smooth Muscle. Circulation Research. https://doi.org/10.1161/01.res.0000126047.82846.20
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
