The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Cytokine-Induced Modulation of Cardiac Function
Open accessAbstract
Cytokines act in an autocrine and/or paracrine fashion to induce a diverse variety of biological responses. Several cardiac diseases are associated with cytokine activation, and such activation significantly influences several physiologic parameters, including cardiac mechanical function. This review summarizes the current concepts regarding the modulation of myocardial function by cytokines and provides rationale for the sometimes-conflicting results in the literature regarding underlying mechanisms and patterns of dysfunction. Although traditionally considered cardiodepressant mediators, contractile responses are complex and bimodal, with an early response (within minutes) of variable direction, stimulatory or depressant, depending on the ambient physiologic milieu and relative contributions of the underlying signaling pathways that are activated. These pathways include sphingomyelinase-, nitric oxide (NO)-, and phospholipase A2-dependent signaling with resultant combined effects on contraction and the Ca 2+ transient. This is subsequently followed by a profoundly cardiodepressant late response lasting hours to days, depending on the production of secondary mediators and the combined influence of NO generated from inducible NO synthase, reactive oxygen species, and alterations in β-adrenergic receptor signaling. The interrelationships between these pathways and the time-dependence of their activation are important considerations in the evaluation of cytokine-dependent dysfunction during both acute cardiac injury and chronic cardiac pathologies.
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Shock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448
Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide
Finkel, M. S., Oddis, C. V., Jacob, T. D., Watkins, S. C., Hattler, B. G., & Simmons, R. L. (1992) · Science · doi:10.1126/science.1631560 · Cited by 1,628
Stamler (2001) · doi:10.1016/s0092-8674(01)00495-0 · Cited by 1,261
Inflammatory Mediators and the Failing Heart: Past, Present, and the Foreseeable Future
Mann, D. L. (2002) · Circulation Research · doi:10.1161/01.res.0000043825.01705.1b · Cited by 988
Okusawa, S., Gelfand, J. A., Ikejima, T., Connolly, R. J., & Dinarello, C. A. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113431 · Cited by 983
Interleukin-1 receptor antagonist reduces mortality from endotoxin shock
Ohlsson, K., Björk, P., Bergenfeldt, M., Hageman, R., & Thompson, R. C. (1990) · Nature · doi:10.1038/348550a0 · Cited by 853
Kubota, T., McTiernan, C. F., Frye, C. S., Slawson, S. E., Lemster, B. H., Koretsky, A. P., Demetris, A. J., & Feldman, A. M. (1997) · Circulation Research · doi:10.1161/01.res.81.4.627 · Cited by 829
Bozkurt, B., Kribbs, S. B., Clubb, F. J., Michael, L. H., Didenko, V. V., Hornsby, P. J., Seta, Y., Oral, H., Spinale, F. G., & Mann, D. L. (1998) · Circulation · doi:10.1161/01.cir.97.14.1382 · Cited by 821
Nathan, C., & Sporn, M. (1991) · The Journal of cell biology · doi:10.1083/jcb.113.5.981 · Cited by 800
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Griffith, L. G., & Swartz, M. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1858 · Cited by 2,290
Tan, Y., Zhang, Z., Zheng, C., Wintergerst, K. A., Keller, B. B., & Cai, L. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0339-2 · Cited by 835
Essandoh, K., Yang, L., Wang, X., Huang, W., Qin, D., Hao, J., Wang, Y., Zingarelli, B., Peng, T., & Fan, G.-C. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.08.010 · Cited by 441
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Afari, M. E., & Bhat, T. (2016) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2016.1154788 · Cited by 439
The varying faces of IL-6: From cardiac protection to cardiac failure
Fontes, J. A., Rose, N. R., & Čiháková, D. (2015) · Cytokine · doi:10.1016/j.cyto.2014.12.024 · Cited by 337
Metadata
- Authors
- Prabhu, S. D.
- Venue
- Circulation Research
- Published
- 2004-12-10
- Volume
- 95
- Issue
- 12
- Pages
- 1140-1153
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2162210935
- Cited by
- 375
- References
- 99
- FWCI
- 7.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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