The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Fetal-Derived Trophoblast Use the Apoptotic Cytokine Tumor Necrosis Factor-α–Related Apoptosis-Inducing Ligand to Induce Smooth Muscle Cell Death
Abstract
Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss of endothelial and smooth muscle cells (SMC) is evident in remodeled arteries but the mechanisms underlying this transformation remain unknown. This study investigated the hypothesis that fetal trophoblast invading from the placenta instigate remodeling by triggering cell death in vascular SMC. Specifically, a role for trophoblast-derived death inducing cytokine tumor necrosis factor-α–related apoptosis-inducing ligand (TRAIL) was investigated. Expression of the activating TRAIL receptors R1 and R2 was detected by flow cytometry on human aortic SMC and by immunohistochemistry on spiral artery SMC. Recombinant human TRAIL induced human aortic SMC apoptosis, which was inhibited by antibodies against TRAIL-R1 or -R2. Perfusion of denuded spiral artery segments with recombinant human TRAIL also induced SMC apoptosis. Trophoblasts isolated from first trimester placenta expressed membrane-associated TRAIL and induced apoptosis of human aortic SMC; apoptosis was significantly inhibited by a recombinant human TRAIL-R1:Fc construct. Trophoblast within the first trimester placental bed also expressed TRAIL. These data show that: 1) TRAIL causes SMC death; 2) trophoblast produce the apoptotic cytokine TRAIL; and 3) trophoblast induce SMC apoptosis via a TRAIL-dependent mechanism. We conclude that TRAIL produced by trophoblast causes apoptosis of SMC and thus may contribute to SMC loss during spiral artery remodeling in pregnancy.
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“There is widespread agreement [416] that a poor connection of the placenta to the uterus leads to ischaemia and thus oxidative stress, with a substantial involvement of apoptosis during the placental remodelling [417-423].”
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KHONG, T. Y., DE WOLF, F., ROBERTSON, W. B., & BROSENS, I. (1986) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1986.tb07830.x · Cited by 1,591
The Uterine Spiral Arteries In Human Pregnancy: Facts and Controversies
Pijnenborg, R., Vercruysse, L., & HANSSENS, M. C. A. J. A. (2006) · Placenta · doi:10.1016/j.placenta.2005.12.006 · Cited by 1,229
Kaufmann, P., Black, S., & Huppertz, B. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.102.014977 · Cited by 1,210
Zhou, Y., Fisher, S. J., Janatpour, M. J., Genbačev, O., Dejana, E., Wheelock, M., & Damsky, C. H. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119387 · Cited by 957
Meekins, J. W., Pijnenborg, R., HANSSENS, M. C. A. J. A., McFadyen, I., & van Asshe, A. (1994) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1994.tb13182.x · Cited by 901
Jo, M., Kim, T., Seol, D., Esplen, J. E., Dorko, K., Billiar, T. R., & Strom, S. C. (2000) · Nature Medicine · doi:10.1038/75045 · Cited by 841
EMERGING ROLES FOR CYSTEINE PROTEASES IN HUMAN BIOLOGY
Chapman, H. A., Riese, R. J., & Shi, G. (1997) · Annual Review of Physiology · doi:10.1146/annurev.physiol.59.1.63 · Cited by 793
Cell Surface Trafficking of Fas: A Rapid Mechanism of p53-Mediated Apoptosis
Bennett, M. R., Macdonald, K., Chan, S., Luzio, J. P., Simari, R. D., & Weissberg, P. L. (1998) · Science · doi:10.1126/science.282.5387.290 · Cited by 755
Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy
Almasan, A., & Ashkenazi, A. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(03)00029-7 · Cited by 547
Kim, Y. M., Bujold, E., Chaiworapongsa, T., Gómez, R., Yoon, B. H., Thaler, H. T., Rotmensch, S., & Romero, R. J. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1067/s0002-9378(03)00838-x · Cited by 387
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Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554
Smith, S. D., Dunk, C., Aplin, J., Harris, L. K., & Jones, R. L. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080995 · Cited by 466
Self-citationTracking placental development in health and disease
Aplin, J., Myers, J., Timms, K., & Westwood, M. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0372-6 · Cited by 401
Self-citationHuman Tumour Necrosis Factor: Physiological and Pathological Roles in Placenta and Endometrium
Haider, S., & Knöfler, M. (2008) · Placenta · doi:10.1016/j.placenta.2008.10.012 · Cited by 344
Remodelling at the maternal–fetal interface: relevance to human pregnancy disorders
Cartwright, J. E., Fraser, R., Leslie, K., Wallace, A. E., & James, J. L. (2010) · Reproduction · doi:10.1530/rep-10-0294 · Cited by 274
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Metadata
- Authors
- Keogh, R. J., Harris, L. K., Freeman, A., Baker, P. N., Aplin, J. D., Whitley, G. S., & Cartwright, J. E.
- Affiliations
- St George's, University of London (GB)
- From the Centre for Developmental and Endocrine Signalling, Division of Basic Medical Sciences (R.J.K., A.F., G.StJ.W., J.E.C.), St. George’s, University of London, Cranmer Terrace, London, UK; and Division of Human Development (L.K.H., P.N.B., J.D.A.), University of Manchester, St. Mary’s Hospital, Hathersage Road, Manchester, UK.
- Venue
- Circulation Research
- Published
- 2007-03-30
- Volume
- 100
- Issue
- 6
- Pages
- 834-841
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2151162913
- Cited by
- 114
- References
- 36
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 9 · 2019: 5 · 2018: 4 · 2017: 7 · 2016: 3 · 2015: 7 · 2014: 1 · 2013: 6 · 2012: 6
- FWCI
- 15.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- St George's Online Research Archive (St George's University of London) (acceptedVersion)
- Funders
- Wellcome Trust (069939)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- tumor necrosis factor-related apoptosis-inducing ligand, TRAIL, trophoblast, smooth muscle cell apoptosis, spiral artery remodeling, uterine spiral arteries, TRAIL receptors, placenta, pregnancy, vascular remodeling, apoptosis
- MeSH terms
- Arteries, Cells, Cultured, Decidua, Female, Fetus, Humans, Muscle, Smooth, Vascular, Myometrium, Pregnancy, Pregnancy Trimester, First, Time Factors, Trophoblasts, Apoptosis, Receptors, Tumor Necrosis Factor, Microscopy, Video, Receptors, TNF-Related Apoptosis-Inducing Ligand, TNF-Related Apoptosis-Inducing Ligand
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