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Reactivity of Vascular Smooth Muscle in Hypertensive Rats
Open accessAbstract
The reactivity of vascular smooth muscle in helical strips from femoral arteries of normotensive, spontaneously hypertensive, renal hypertensive, and deoxycorticosterone acetate-- (DCA-) hypertensive rats was studied. Spontaneous rhythmic contractions occurred in 25 of the 30 strips from the three groups of hypertensive rats and in only 2 of the 10 strips from normotensive rats. Strips from renal and DCA hypertensive rats had lower thresholds to epinephrine and potassium chloride (KCl) than did strips from spontaneously hypertensive and normotensive rats. Lanthanum (2.5 mM) caused contraction of all 10 strips from spontaneously hypertensive rats but failed to cause contraction of any strip from the other three groups of rats. Strontium (5 mM) caused contraction in 8 of 10 strips from spontaneously hypertensive rats but caused contraction in only 7 of the 30 strips from the other three groups. The optimal calcium concentration for tension development in response to a KCl stimulus was approximately twice as high for strips from hypertensive rats as it was for strips from normotensive rats. Strips from DCA-hypertensive rats showed less tachyphylaxis to angiotensin II than did strips from the other three groups of rats. These results quantify our earlier observation that the reactivity of vascular smooth muscle from hypertensive rats is importantly different from that of normotensive rats. In addition, the study delineates individuality in vascular smooth muscle reactivity in different types of experimental hypertension. The results suggest that the cell membrane of the vascular smooth muscle in the hypertensive rat is more labile than that in the normal rat.
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Citations
Cited by
de Wardener, H. E., & MacGregor, G. A. (1980) · Kidney International · doi:10.1038/ki.1980.104 · Cited by 375
Vasomotion: Mechanisms and Physiological Importance
Nilsson, H. (2003) · Molecular Interventions · doi:10.1124/mi.3.2.79 · Cited by 342
Regulation of smooth muscle calcium sensitivity: KCl as a calcium-sensitizing stimulus
Ratz, P. H., Berg, K. M., Urban, N. H., & Miner, A. S. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00529.2004 · Cited by 287
Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension
Brown, I. A. M., Diederich, L., Good, M. E., DeLalio, L. J., Murphy, S. A., Cortese-Krott, M. M., Hall, J. L., Le, T. H., & Isakson, B. E. (2018) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.118.311229 · Cited by 266
Calcium metabolism and parathyroid function in primary aldosteronism
Resnick, L. M., & Laragh, J. H. (1985) · The American Journal of Medicine · doi:10.1016/0002-9343(85)90328-6 · Cited by 111
Metadata
- Authors
- HOLLOWAY, E. T., & BOHR, D. F.
- Venue
- Circulation Research
- Published
- 1973-12
- Volume
- 33
- Issue
- 6
- Pages
- 678-685
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2101574407
- Cited by
- 199
- References
- 0
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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- HOLLOWAY, E. T., & BOHR, D. F. (1973). Reactivity of Vascular Smooth Muscle in Hypertensive Rats. Circulation Research. https://doi.org/10.1161/01.res.33.6.678
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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