The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Stimulation of soluble guanylate cyclase by an acetylcholine-induced endothelium-derived factor from rabbit and canine arteries
Open accessAbstract
The present study was designed to investigate the hypothesis that, during acetylcholine-induced endothelium-dependent relaxation, a factor(s) is released from endothelial cells which directly activates soluble guanylate cyclase. We attempted to determine what similarities or differences existed between this factor and endothelium-derived relaxing factor. The study was performed on segments of rabbit aorta and canine femoral artery. Purified soluble guanylate cyclase was injected into the lumen of these vascular segments, together with its substrate, for intraluminal incubation of the enzyme. In endothelium-intact vascular segments, the activity of guanylate cyclase was enhanced over control values obtained by incubation in test tubes. The stimulation was further increased by acetylcholine in concentrations which caused relaxation of the vascular segments. The stimulating principle could not be transferred from the vessel lumen to an external solution of guanylate cyclase, indicating a short life-time. Removal of the endothelium prevented formation and release of the guanylate cyclase stimulating factor(s). Atropine, mepacrine, or nordihydroguaiaretic acid, which inhibit acetylcholine-induced endothelium-dependent relaxations, also inhibited acetylcholine-induced endothelium-mediated activation of guanylate cyclase. The results support the hypothesis that acetylcholine-induced endothelium-derived relaxing factor increases cyclic guanosine monophosphate levels of vascular smooth muscle by a stimulation of soluble guanylate cyclase.
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“NO synthesized by NOS in the endothelium diffuses into the vessel wall where it activates sGC in vascular smooth muscle; this leads to a rise in cyclic GMP (cGMP) and elicits relaxation of the vessel [96-102].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [98]
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Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064
Role of endothelium in responses of vascular smooth muscle.
Furchgott, R. F. (1983) · Circulation Research · doi:10.1161/01.res.53.5.557 · Cited by 1,961
The Role of Endothelium in the Responses of Vascular Smooth Muscle to Drugs
Furchgott, R. F. (1984) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.24.040184.001135 · Cited by 937
The Pharmacological and Physiological Role of Cyclic GMP in Vascular Smooth Muscle Relaxation
Ignarro, L. J., & Kadowitz, P. J. (1985) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.25.040185.001131 · Cited by 679
The nature of endothelium-derived vascular relaxant factor
Griffith, T. M., Edwards, D. H., LEWIS, M. J., Newby, A. C., & Henderson, A. H. (1984) · Nature · doi:10.1038/308645a0 · Cited by 581
The regeneration of aortic endothelium
Poole, J. C. F., Sanders, A. G., & Florey, H. W. (1958) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700750116 · Cited by 371
Mey, J. G. R. D., Claeys, M., & Vanhoutte, P. (1982) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)33169-1 · Cited by 353
Endothelial Cells as Mediators of Vasodilation of Arteries
Furchgott, R. F., Cherry, P. D., Zawadzki, J. V., & Jothianandan, D. (1984) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-198406002-00008 · Cited by 322
Ignarro, L. J., Burke, T. M., Wood, K. S., Wolin, M. S., & Kadowitz, P. J. (1984) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21916-4 · Cited by 265
Rapoport, R. M., & Murad, F. (1983) · PubMed · Cited by 259
The role of prostaglandins in the endothelium-mediated vasodilatory response to hypoxia
Busse, R., F�rstermann, U., Matsuda, H., & Pohl, U. (1984) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00581536 · Cited by 179
Self-citationEndothelial cells are involved in the vasodilatory response to hypoxia
Busse, R., Pohl, U., Kellner, C., & Klemm, U. (1983) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00585175 · Cited by 146
Self-citationPurifieation of a Soluble, Sodium‐Nitroprusside‐Stimulated Guanylate Cyclase from Bovine Lung
Gerzer, R., Hofmann, F. B., & Schultz, G. (1981) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1981.tb05361.x · Cited by 146
Species-dependent differences in the nature of endothelium-derived vascular relaxing factor
Förstermann, U., Trogisch, G., & Busse, R. (1984) · European Journal of Pharmacology · doi:10.1016/0014-2999(84)90071-2 · Cited by 113
Self-citationRapoport, R. M., Draznin, M. B., & Murad, F. (1984) · Circulation Research · doi:10.1161/01.res.55.4.468 · Cited by 80
Diamond, J., & Eb, C. (1983) · PubMed · Cited by 75
Miller, R. C., Mony, M. M., Schini‐Kerth, V. B., Schoeffter, P., & Stoclet, J. C. (1984) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1984.tb16530.x · Cited by 73
Förstermann, U., & Neufang, B. (1984) · European Journal of Pharmacology · doi:10.1016/0014-2999(84)90190-0 · Cited by 73
Self-citationGruetter, D. Y., Gruetter, C. A., Barry, B. K., Baricos, W. H., Hyman, A. L., Kadowitz, P. J., & Ignarro, L. J. (1980) · Biochemical Pharmacology · doi:10.1016/0006-2952(80)90042-8 · Cited by 62
Guanylate Cyclase: Regulation of Cyclic GMP Metabolism
Mittal, C. K., & Murad, F. (1982) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-68111-0_5 · Cited by 47
Böhme, E., Grossmann, G., Herz, J., Mülsch, A., Spies, C., & Schultz, G. (1984) · PubMed · Cited by 42
Self-citation
Research works printed but not linked: 2
- Bohme E, Gerzer R, Grossmann G, Herz J, Mulsch A, Spies C, Schultz G (1983) Regulation of soluble guanylate cyclase activ- ity. In Hormones and Cell Regulation, vol 7, edited by JE Dumont, J Nunez, RM Denton. Amsterdam, Elsevier Biomedi- cal Press, pp 147-161
- Furchgott RF, Zawadzki JV, Cherry PD (1981) Role of endothe- lium in the vasodilator response to acetylcholine. In Vasodila- tion, edited by PM Vanhoutte, I Leusen. New York, Raven Press, pp 49-66
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Sorted by citations
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074
Nitric oxide synthases: regulation and function
Forstermann, U., & Sessa, W. C. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr304 · Cited by 4,409
Self-citationAbnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension
Panza, J. A., Quyyumi, A. A., Brush, J. E., & Epstein, S. E. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007053230105 · Cited by 2,366
Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions.
Förstermann, U., Closs, E. I., Pollock, J. S., Nakane, M., Schwarz, P., Gath, I., & Kleinert, H. (1994) · Hypertension · doi:10.1161/01.hyp.23.6.1121 · Cited by 1,122
Self-citationPollock, J. S., Förstermann, U., Mitchell, J. A., Warner, T. D., Schmidt, H. H. H. W., Nakane, M., & Murad, F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10480 · Cited by 979
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Metadata
- Authors
- Förstermann, U., Mülsch, A., Böhme, E., & Busse, R.
- Venue
- Circulation Research
- Published
- 1986-04
- Volume
- 58
- Issue
- 4
- Pages
- 531-538
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2130054105
- Cited by
- 288
- References
- 21
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 7 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 3 · 2016: 2 · 2015: 6 · 2014: 7 · 2013: 2 · 2012: 6
- FWCI
- 22.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- soluble guanylate cyclase, acetylcholine, endothelium-derived relaxing factor, endothelium-dependent relaxation, cyclic GMP, vascular smooth muscle, endothelial cells, aorta, femoral artery, atropine, quinacrine, nordihydroguaiaretic acid, guanylate cyclase activation
- MeSH terms
- Acetylcholine, Animals, Aorta, Thoracic, Cyclic CMP, Dogs, Endothelium, Enzyme Activation, Femoral Artery, Guanylate Cyclase, Muscle Relaxation, Muscle, Smooth, Vascular, Nitric Oxide, Nitroprusside, Rabbits, Vasodilator Agents
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