CoChat
Sign Up
Cited by 130Mitochondrial Function and PathologyCardiac Ischemia and ReperfusionCardiovascular Function and Risk Factors

The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.

Intracellular Ca 2+ Increases the Mitochondrial NADH Concentration During Elevated Work in Intact Cardiac Muscle

Brandes, Rolf, Bers, Donald M.·1997·Circulation Research
DOI 10.1161/01.res.80.1.82
Open this paper in CoChat — free account

Abstract

It is not clear how mitochondrial energy production is regulated in intact tissue when energy consumption suddenly changes. Whereas mitochondrial [NADH] ([NADH] m ) may regulate cellular respiration rate and energetic state, it is not clear how [NADH] m itself is controlled during increased work in vivo. We have varied work and [Ca 2+ ] in intact cardiac muscle while assessing [NADH] m using fluorescence spectroscopy. When increased work was accompanied by increasing average [Ca 2+ ] c (by increasing [Ca 2+ ] o or pacing frequency), [NADH] m initially fell and subsequently recovered to a new steady state level. Upon reduction of work, [NADH] m overshot and then returned to control levels. In contrast, when work was increased without increasing average [Ca 2+ ] c (by increasing sarcomere length), [NADH] m fell similarly, but no recovery or overshoot was observed. This Ca 2+ -dependent recovery and overshoot may be attributed to Ca 2+ -dependent stimulation of mitochondrial dehydrogenases. We conclude that the immediate initial increase in respiration rate upon elevation of work is not activated by increased [NADH] m (since [NADH] m rapidly fell) or by [Ca 2+ ] c (since work could also be increased at constant [Ca 2+ ] c ). However, during sustained high work, a Ca 2+ -dependent mechanism causes slow recovery of [NADH] m toward control values. This demonstrates a Ca 2+ -dependent feed-forward control mechanism of cellular energetics in cardiac muscle during increased work.

Overview

Integrity signals

Registry

Crossref · 10.1161/01.res.80.1.82

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 32 references

Research works printed but not linked: 2

  1. 10.1161/res.64.4.2702736 · DOI
  2. 10.1161/res.68.3.1742869 · DOI

Cited by

Sorted by citations

Items 101–130 of 130

Related

See all

Metadata

Authors
Brandes, R., & Bers, D. M.
Affiliations
  • the Department of Physiology, Loyola University Chicago, School of Medicine, Maywood, Ill. E-mail rbrande@luc.edu
  • Loyola University Chicago (US)
ORCID
Bers, Donald M.
Venue
Circulation Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1997-01
Volume
80
Issue
1
Pages
82-87
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
DOI
10.1161/01.res.80.1.82
OpenAlex
W1979697035
Cited by
130
References
32
Citations by year
2026: 3 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 3 · 2013: 5 · 2012: 4
FWCI
2.37
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01hl052478-05)
  • National Heart, Lung, and Blood Institute (HL52478, HL30077)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
intracellular calcium, mitochondrial NADH, myocardium, mitochondrial respiration, energy metabolism, sarcomere length, pacing rate, mitochondrial dehydrogenases, feedforward control, NADH fluorescence
MeSH terms
Animals, Calcium, Energy Metabolism, Intracellular Membranes, Kinetics, Male, Mitochondria, NAD, Osmolar Concentration, Papillary Muscles, Rats, Inbred Strains, Temperature, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review