The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Lipoprotein lipase increases lipoprotein binding to the artery wall and increases endothelial layer permeability by formation of lipolysis products.
Abstract
Mechanisms responsible for the accumulation of low-density lipoprotein (LDL) were investigated in a new model, the perfused hamster aorta. To do this, we developed a method to study LDL flux in real time in individually perfused arteries; each artery served as its own control. Using quantitative fluorescence microscopy, the rates of LDL accumulation and efflux were separately determined. Perfusion of arteries with buffer plus lipoprotein lipase (LpL) increased LDL accumulation 5-fold (0.1 +/- 0.03 mV/min [control] versus 0.5 +/- 0.05 mV/min [LpL]) by increasing LDL retention in the artery wall. This effect was blocked by heparin and monoclonal antibodies directed against the amino-terminal region of apolipoprotein B (apo B). This suggests that specific regions of apo B are involved in LDL accumulation within arteries. Also, the effect of hydrolysis of triglyceride-rich lipoproteins on endothelial barrier function was studied. We compared endothelial layer permeability using a water-soluble reference molecule, fluorescently labeled dextran. When LpL was added to hypertriglyceridemic plasma, dextran accumulation within the artery wall increased > 4-fold (0.024 +/- 0.01 mV/min [control] versus 0.098 +/- 0.05 mV/min [LpL]). Under the same conditions, LpL increased LDL accumulation approximately 3-fold (0.016 +/- 0.003 mV/min [control] versus 0.047 +/- 0.013 mV/min [LpL]). Rapid efflux of LDL from the artery wall indicated that increased endothelial layer permeability was the primary mechanism during periods of increased lipolysis. Our data demonstrate two LpL-mediated effects that may increase the amount of LDL in the artery wall. These findings may pertain to the observed relationship between increased postprandial lipemia and atherosclerosis.
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“In addition, ex vivo studies have shown that lipolysis leads to increased permeability of blood vessels (150), which may allow greater infiltration of LDL.”
From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [150]
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Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
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Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state
Patsch, J. R., Miesenböck, G., Hopferwieser, T., Mühlberger, V, Knapp, E., Dunn, J. K., Gotto, A. M., & Patsch, W. (1992) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.12.11.1336 · Cited by 1,122
Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis
Goldberg, I. J. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37569-6 · Cited by 1,029
Self-citationA stable, radioactive substrate emulsion for assay of lipoprotein lipase
Nilsson‐Ehle, P., & Schotz, M. C. (1976) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41752-3 · Cited by 841
Postprandial lipoprotein metabolism in normolipidemic men with and without coronary artery disease.
Groot, P. H. E., van Stiphout, W. A. H. J., Krauss, X. H., Jansen, H., van Tol, A., van Ramshorst, E., Chin-On, S., Albert Hofman, D., Cresswell, S. R., & Havekes, L. M. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.3.653 · Cited by 528
Postprandial lipoproteins and progression of coronary atherosclerosis
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Lipid-Mediated Mechanisms in Atherosclerosis
Caudle, W., Sarhan, M., Liu, Q., Martinez, J., Hodge, J., & Fan, D. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-15734-9.00059-5
Metadata
- Authors
- Rutledge, J. C., Woo, M. M., Rezai, A. A., Curtiss, L. K., & Goldberg, I. J.
- Affiliations
- Scripps Research Institute (US)
- ORCID
- Goldberg, Ira J.
- Venue
- Circulation Research
- Published
- 1997-06
- Volume
- 80
- Issue
- 6
- Pages
- 819-828
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2101670650
- Cited by
- 101
- References
- 48
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 5.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p50hl021006-17)
- National Heart, Lung, and Blood Institute (HL55667, HL45095, HL 21006, R01HL055667)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Keywords
- lipoprotein lipase, apolipoprotein B, lipolysis, endothelial permeability, triglyceride-rich lipoproteins, hypertriglyceridemia, postprandial lipemia, atherosclerosis, heparin, monoclonal antibodies
- MeSH terms
- Animals, Arteries, Capillary Permeability, Endothelium, Vascular, Cricetinae, Lipolysis, Lipoprotein Lipase, Lipoproteins, Lipoproteins, LDL, Mesocricetus, Microscopy, Fluorescence
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