Cited by 399Cardiac electrophysiology and arrhythmiasCardiac Arrhythmias and TreatmentsIon Transport and Channel Regulation

The DOI matches its Crossref record; 48 of the 49 references it cites were found in a registry or an index.

Upregulation of Na+/Ca2+Exchanger Expression and Function in an Arrhythmogenic Rabbit Model of Heart Failure

Open access

Pogwizd, Steven M., Qi, Ming, Yuan, Weilong, Samarel, Allen M., Bers, Donald M.·1999·Circulation Research

DOI 10.1161/01.res.85.11.1009

Open this paper in CoChat — free account Open PDF

Abstract

Abstract—Three-dimensional cardiac mapping in rabbits with nonischemic cardiomyopathy has shown that ventricular arrhythmias initiate by a nonreentrant mechanism that may be due to triggered activity from delayed afterdepolarizations. Delayed afterdepolarizations are thought to be due to spontaneous release of Ca 2+from the sarcoplasmic reticulum (SR) and consequent activation of an inward Na+/Ca 2+exchange (NaCaX) current. The goal of this study was to determine whether there is enhanced NaCaX gene expression and functional activity that may contribute to nonreentrant activation. Heart failure (HF) was induced in rabbits by combined aortic insufficiency and aortic constriction. HF rabbits had left ventricular enlargement (left ventricular end-diastolic dimension increased from 1.43±0.03 to 1.97±0.05 cm) and severely depressed function (fractional shortening reduced from 37% to 26%,P<0.02). Heart-to-body weight was increased by 79% in HF. Western blots showed a 93% increase in NaCaX protein in HF (P<0.04). NaCaX mRNA (7-kb transcript) was increased by 104% relative to the 18S rRNA in HF. A 14-kb NaCaX transcript was also seen in the HF rabbits, raising total NaCaX mRNA to 2.7-fold compared with controls. The amplitude of caffeine-induced contractures, used to assess SR Ca 2+load, was not significantly different in HF. Relaxation and [Ca 2+]i decline during caffeine-induced contractures is attributable to Ca 2+transport by NaCaX and was 61% and 45% faster in HF (P<0.05), respectively. NaCaX current measured under controlled voltage clamp conditions was also 2-fold higher in HF cells. SR Ca 2+-ATPase mRNA and protein levels and Ca 2+current density were not significantly altered in HF. Twitch amplitudes from HF myocytes were 26% smaller compared with control (P<0.02), but twitch relaxation and [Ca 2+]i decline (due largely to SR Ca 2+-ATPase) were not altered. Thus myocytes and myocardium from HF rabbits exhibit enhanced NaCaX expression and function. The enhanced NaCaX activity may contribute to depressed contractions, increased transient inward current (for a given SR Ca 2+release), delayed afterdepolarizations, and nonreentrant initiation of ventricular tachycardia in this arrhythmogenic model of HF.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/01.res.85.11.1009

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.
Towbin, H., Staehelin, T., & Gordon, J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.9.4350 · Cited by 53,218
Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.
Sahn, D. J., DeMaria, A. N., KISSLO, J. A., & Weyman, A. E. (1978) · Circulation · doi:10.1161/01.cir.58.6.1072 · Cited by 7,430
Calcium Sparks: Elementary Events Underlying Excitation-Contraction Coupling in Heart Muscle
Cheng, H., Lederer, W. J., & Cannell, M. B. (1993) · Science · doi:10.1126/science.8235594 · Cited by 1,945
Evaluation of aortic insufficiency by Doppler color flow mapping
Perry, G. J., Helmcke, F., Nanda, N. C., Byard, C., & Soto, B. (1987) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(87)80254-1 · Cited by 881
Mechanisms of Altered Excitation-Contraction Coupling in Canine Tachycardia-Induced Heart Failure, II
Winslow, R. L., Rice, J. J., Jafri, S., Marbán, E., & O'Rourke, B. P. (1999) · Circulation Research · doi:10.1161/01.res.84.5.571 · Cited by 797
Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure
Gomez, A. M., Valdivia, H. H., Cheng, H., Lederer, M. R., Santana, L. F., Cannell, M. B., McCune, S. A., Altschuld, R. A., & Lederer, W. J. (1997) · Science · doi:10.1126/science.276.5313.800 · Cited by 758
Relaxation in rabbit and rat cardiac cells: species-dependent differences in cellular mechanisms
Bassani, J. W., Bassani, R. A., & Bers, D. M. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020130 · Cited by 662
Self-citation
Gene expression of the cardiac Na(+)-Ca2+ exchanger in end-stage human heart failure.
Studer, R., Reinecke, H., Bilger, J., Thomas Eschenhagen, A., Böhm, M., Hasenfuss, G. P., Just, H., Holtz, J., & Drexler, H. (1994) · Circulation Research · doi:10.1161/01.res.75.3.443 · Cited by 633
Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes
Bassani, J. W. M., Yuan, W., & Bers, D. M. (1995) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1995.268.5.c1313 · Cited by 549
Self-citation

Show all 49 references

Research works printed but not linked: 17

10.1161/circ.72.4.2863012 · DOI
10.1161/circ.92.4.1034 · DOI
10.1161/res.75.3.8062418 · DOI
10.1161/circ.94.5.992 · DOI
10.1161/res.72.2.8418995 · DOI
10.1161/res.74.4.8137493 · DOI
10.1016/0003-2697(87)90021-2 · DOI
10.1161/res.84.5.562 · DOI
Rose J, O’Rourke B, Kass DA, Tomaselli GF. Na+-Ca2+ exchange (NCX) current density is unchanged in heart failure despite an increase in NCX protein. Circulation. 1998;98:I-679 (abstract).
10.1161/res.74.2.8293564 · DOI
10.1161/res.81.6.1083 · DOI
10.1161/res.85.1.38 · DOI
10.1161/circ.99.5.641 · DOI
10.1161/res.73.1.8508529 · DOI
10.1161/circ.90.2.8044934 · DOI
10.1161/circ.92.11.3220 · DOI
10.1161/res.82.6.657 · DOI

Sorted by citations

Items 301–397 of 397

Ventricular Arrhythmias Following Exposure of Failing Hearts to Oxidative Stress in Vitro
Brigadeau, F., Gelé, P., Marquié, C., Soudan, B., & Lacroix, D. (2005) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2005.40584.x · Cited by 11
Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity
Ang, R., & Marina, N. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00236 · Cited by 10
Prominent Heart Organ-Level Performance Deficits in a Genetic Model of Targeted Severe and Progressive SERCA2 Deficiency
Heinis, F. I., Andersson, K. B., Christensen, G., & Metzger, J. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079609 · Cited by 10
Alteration of Myocardial Sarcoplasmic Reticulum Ca2+-ATPase and Na+–Ca2+ Exchanger Expression in Human Left Ventricular Volume Overload
Leszek, P., Szperl, M., Klisiewicz, A., Janas, J., Biederman, A., Rywik, T. M., Piotrowski, W., Kopacz, M., & Korewicki, J. (2007) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2007.01.011 · Cited by 10
Would modulation of intracellular Ca2+ be antiarrhythmic?
Boyden, P. A., & ter Keurs, H. E. D. J. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.03.011 · Cited by 10
Retinoic acid increased expression of the Na+/Ca2+ exchanger in the heart and brain.
Hudecová, S., Štefánik, P., Macejová, D., Brtko, J., & Križanová, O. (2004) · PubMed · Cited by 10
The Ins and Outs of Calcium in Heart Failure
O'Rourke, B. P. (2008) · Circulation Research · doi:10.1161/circresaha.108.178095 · Cited by 10
Influence of a constitutive increase in myofilament Ca2+-sensitivity on Ca2+-fluxes and contraction of mouse heart ventricular myocytes
Puglisi, J. L., Goldspink, P. H., Gomes, A. V., Utter, M. S., Bers, D. M., & Solaro, R. J. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.01.019 · Cited by 9
Self-citation
Ryanodine receptor Ca2+sensitivity and excitation-contraction coupling in muscular dystrophy and heart failure: similar and yet different
Shannon, T. R. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00945.2009 · Cited by 9
Activation of protein kinase C ε enhanced movement ability and paracrine function of rat bone marrow mesenchymal stem cells partly at least independent of SDF-1/CXCR4 axis and PI3K/AKT pathway.
He, H., Zhao, Z., Han, F., Wang, X., & Zeng, Y.-J. (2015) · Europe PMC (PubMed Central) · Cited by 9
Pathways Regulating Na+/Ca2+ Exchanger Expression in the Heart
Menick, D. R., Xu, L., Kappler, C. S., JIANG, W., WITHERS, P. R., Shepherd, N., Conway, S. J., & Müller, J. G. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04746.x · Cited by 9
Combined parasympathetic-sympathetic nerve discharge and pulmonary vein afterdepolarizations: A new unifying concept with basic and clinical relevance
Nattel, S. (2005) · Heart Rhythm · doi:10.1016/j.hrthm.2005.03.001 · Cited by 9
Evidence for a modulatory effect of external potassium ions on ionic current mediated by the cardiac Na+–Ca2+ exchanger
Zhang, Y. (2003) · Cell Calcium · doi:10.1016/s0143-4160(02)00181-1 · Cited by 9
Inhibition of the sarcoplasmic reticulum Ca2+ pump with thapsigargin to estimate the contribution of Na+-Ca2+ exchange to ventricular myocyte relaxation
Bassani, R. A., & Bassani, J. W. M. (2003) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2003001200014 · Cited by 8
Na+-K+-ATPase α2-isoform expression in guinea pig hearts during transition from compensation to decompensation
Trouvé, P., Carré, F., Bélikova, I., Leclercq, C., Dakhli, T., Soufir, L., Coquard, I., Ramirez‐Gil, J. F., & Charlemagne, D. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.4.h1972 · Cited by 8
Increased sodium/calcium exchanger activity enhances beta-adrenergic–mediated increase in heart rate: Whole-heart study in a homozygous sodium/calcium exchanger overexpressor mouse model
Kaese, S., Bögeholz, N., Pauls, P., Dechering, D. G., Olligs, J., Kölker, K., Badawi, S., Frommeyer, G., Pott, C., & Eckardt, L. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.05.001 · Cited by 8
RETRACTION: Pre- or Post-Ischemic Treatment with a Novel Na+/Ca2+ Exchange Inhibitor, KB-R7943, Shows Renal Protective Effects in Rats with Ischemic Acute Renal Failure
Yamashita, J., Itoh, M., Kuro, T., Kobayashi, Y., Ogata, M., Takaoka, M., & Matsumura, Y. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38749-x · Cited by 8
Sudden cardiac arrest in patients with preserved left ventricular systolic function: A clinical dilemma
Sawhney, N. S., & Narayan, S. M. (2008) · Heart Rhythm · doi:10.1016/j.hrthm.2008.10.006 · Cited by 7
Ion channel trafficking implications in heart failure
Reisqs, J., Qu, Y. S., & Boutjdir, M. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1351496 · Cited by 6
Instabilities of the resting state in a mathematical model of calcium handling in cardiac myocytes
Tveito, A., Lines, G. T., Hake, J. E., & Edwards, A. G. (2012) · Mathematical Biosciences · doi:10.1016/j.mbs.2012.02.005 · Cited by 6
Fosinopril and Carvedilol Reverse Hypertrophy and Change the Levels of Protein Kinase Cɛ and Components of its Signaling Complex
He, H., Wang, W., Zhang, H., Ma, L., Wu, H., Wang, P., & Gao, J. (2006) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-006-0079-5 · Cited by 6
Molecular and Pharmacological Aspects
Shigekawa, M., & Iwamoto, T. (2001) · Cited by 6
Targeting SERCA2a as an innovative approach to the therapy of congestive heart failure
Ferrari, P., Micheletti, R., Valentini, G., & Bianchi, G. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.08.045 · Cited by 6
Does enhanced expression of the Na+-CA2+ exchanger increase myocardial vulnerability to ischemia/reperfusion injury in rabbit hearts?
Matsumoto, T., Miura, T., Miki, T., Nishino, Y., Nakamura, Y., & Shimamoto, K. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1024140419688 · Cited by 6
Local Ca 2+ Release in Heart Failure
Sipido, K. R. (2000) · Circulation Research · doi:10.1161/01.res.87.11.966 · Cited by 6
Pharmacokinetics and safety of intramuscular injection of concentrated certriaxone in children.
Bradley, J. S., Compogiannis, L. S., Murray, W. E., Acosta, M., & Tsu, G. L. (1992) · PubMed · Cited by 6
A method to increase reproducibility in adult ventricular myocyte sizing and flow cytometry: Avoiding cell size bias in single cell preparations
López, J. E., Jaradeh, K., Silva, E., Aminololama‐Shakeri, S., & Simpson, P. C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186792 · Cited by 6
Altered sarco(endo)plasmic reticulum calcium adenosine triphosphatase 2a content: Targets for heart failure therapy
Liu, G., Li, S. Q., Hu, P. P., & Tong, X. Y. (2018) · Diabetes and Vascular Disease Research · doi:10.1177/1479164118774313 · Cited by 6
Using a Failing Human Ventricular Cardiomyocyte Model to Re-Evaluate Ca2+ Cycling, Voltage Dependence, and Spark Characteristics
Alvarez, J. A. E., Jafri, M. S., & Ullah, A. (2024) · Biomolecules · doi:10.3390/biom14111371 · Cited by 5
Contribution of Sarcoplasmic Reticulum Ca2+ Release and Ca2+ Transporters on Sarcolemmal Channels to Ca2+ Transient in Fetal Mouse Heart
Takizawa, M., Ishiwata, T., Kawamura, Y., Kanai, T., Kurokawa, T., Nishiyama, M., Ishida, H., Asano, Y., & Nonoyama, S. (2010) · Pediatric Research · doi:10.1203/pdr.0b013e31820bc69b · Cited by 5
Electrical and mechanical alternans during ventricular tachycardia with moderate chronic heart failure
Chinyere, I. R., Moukabary, T., Goldman, S., & Juneman, E. B. (2017) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2017.09.002 · Cited by 5
Measuring Intranuclear and Nuclear Envelope [Ca2+] vs. Cytosolic [Ca2+]
Ljubojević-Holzer, S., & Bers, D. M. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1755-6_12 · Cited by 5
Self-citation
The role of stretch, tachycardia and sodium‐calcium exchanger in induction of early cardiac remodelling
Djalinac, N., Ljubojević-Holzer, S., Matzer, I., Kolesnik, E., Jandl, K., Lohberger, B., Rainer, P. P., Heinemann, Á., Sedej, S., von Lewinski, D., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15504 · Cited by 5
Basic Physiology and Hemodynamics of Cardiac Pacing
Prinzen, F. W., Spinelli, J., & Auricchio, A. (2007) · Elsevier eBooks · doi:10.1016/b978-1-4160-2536-8.50014-5 · Cited by 5
CaMKII in the Heart: From Homeostasis to Pathology
Mattiazzi, A. R., & Bers, D. M. (2026) · Annual Review of Physiology · doi:10.1146/annurev-physiol-043024-114759 · Cited by 6
Self-citation
Early changes in contractility indices and fibrosis in two minimally invasive congestive heart failure models☆
Vilarinho, K. A. D. S., Petrucci, O., Baker, R. S., Vassallo, J., Schenka, A. A., Duffy, J. Y., de Oliveira, P. P. M., & Vieira, R. W. (2009) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2009.06.011 · Cited by 4
Rise of palmitoylation: A new trick to tune NCX1 activity
Gök, Ç., & Fuller, W. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2024.119719 · Cited by 4
Physiology of Cardiac Pacing and Resynchronization
Prinzen, F. W., Vernooy, K., Lumens, J., & Auricchio, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-37804-8.00007-9 · Cited by 4
Lysophosphatidylcholine Increases Na+/Ca2+ Exchanger Expression via RhoB-Geranylgeranylation in H9c2 Cells
Maeda, S., Sakamoto, K., Matsuoka, I., Iwamoto, T., & Kimura, J. (2009) · Journal of Pharmacological Sciences · doi:10.1254/jphs.08253fp · Cited by 4
Molecular and Cellular Mechanisms of Cardiac Arrhythmias
DeMazumder, D., & Tomaselli, G. F. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-381510-1.00041-7 · Cited by 4
Electrical and Structural Remodeling of the Ventricular Myocardium in Disease
Armoundas, A. A., & Tomaselli, G. F. (2003) · Contemporary cardiology · doi:10.1007/978-1-59259-362-0_7 · Cited by 4
Beneficial action potential duration–shortening effects, but deleterious negative inotropism of IKs-activator docosahexaenoyl glycine in long QT syndrome type 2
Louradour, J., Hornyik, T., de la Cruz, A., Iñigo, I. H., Alerni, N., Barbieri, M., López, R., Perez‐Feliz, S., Serrato, L. A. M., Nimani, S., et al. (2025) · EP Europace · doi:10.1093/europace/euaf168 · Cited by 5
Sarcoplasmic Reticulum Ca Homeostasis and Heart Failure
Zima, A. V., & Terentyev, D. A. (2013) · Biological and medical physics series · doi:10.1007/978-1-4614-7678-8_2 · Cited by 3
Atrial remodeling: evolving concepts.
Biffi, M., & Boriani, G. (2003) · PubMed · Cited by 3
Modulation of the Na+/Ca2+ Exchanger by Isoprenaline, Adenosine, and Endothelin‐1 in Guinea Pig Ventricular Myocytes
Zhang, Y. H., Hinde, A. K., James, A. F., & Hancox, J. C. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04789.x · Cited by 3
Effect of Nifekalant, a Class III Anti-Arrhythmic Agent, on Ca2+ Waves in Rat Intact Trabeculae
Hirose, M., Miura, M., Wakayama, Y., Endo, H., Sugai, Y., Stuyvers, B. D. M. Y., Kagaya, Y., Watanabe, J., ter Keurs, H. E., & Shirato, K. (2005) · Circulation Journal · doi:10.1253/circj.69.739 · Cited by 3
WITHDRAWN: Simvastatin prevents decreased SERCA2a activity in non-ischemic heart failure in rabbits via inhibition of β-adrenergic signaling
Zou, C., Liu, Z., Qu, F., Lu, W., Han, L., Song, J., Jiang, B., & Yang, X. (2010) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2010.09.015 · Cited by 2
Retracted
Ryanodine Receptor Channelopathies in Skeletal and Cardiac Muscle
Hanna, A. D., Sharp, L., & Hamilton, S. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802002-9.00003-0 · Cited by 2
Oxidative Stress and Modulation of Cardiac Kv1.5 Channel
Bhuyan, R., & Chakraborti, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-8273-4_9 · Cited by 2
Ion Channels and Cardiac Arrhythmia in Heart Disease
Makielski, J. C., & Fozzard, H. A. (2002) · Comprehensive physiology · doi:10.1002/cphy.cp020119 · Cited by 2
α1-Adrenergic Stress Induces Downregulation of Na+/Ca2+ Exchanger in Myocardial Preparations from Rabbits at Physiological Preload
Schillinger, W., Christians, C., Sossalla, S. T., Teucher, N., Văn, P. N., Kögler, H., Zeitz, O., & Hasenfuss, G. P. (2007) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2006.10.014 · Cited by 2
Excitation–contraction coupling in the MLP knockout mouse
Hoit, B. D. (2006) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.01.004 · Cited by 2
Effect of losartan on the Na+/Ca2+ exchanger in left ventricle of the insulin resistant and hypertensive hHTg rat.
Križanová, O., ŠEBÖKOVÁ, E., & Klimeś, I. (2002) · PubMed · Cited by 2
Amiodarone prevents wave front-tail interactions in patients with heart failure: an in silico study
Gray, R. A., & Franz, M. R. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00227.2023 · Cited by 1
Model Systems for Addressing Mechanism of Arrhythmogenesis in Cardiac Repair
Zhang, X.-D., Thai, P. N., Lieu, D. K., & Chiamvimonvat, N. (2021) · Current Cardiology Reports · doi:10.1007/s11886-021-01498-z · Cited by 1
Increased Risk for Atrial Alternans in Rabbit Heart Failure: The Role of Ca2+/Calmodulin-Dependent Kinase II and Inositol-1,4,5-trisphosphate Signaling
Kanaporis, G., & Blatter, L. A. (2023) · Biomolecules · doi:10.3390/biom14010053 · Cited by 1
Small Animal Models for Arrhythmia Studies
Lee, J., & Tsuji, Y. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6658-2_13 · Cited by 1
Integrated Calcium Management in Cardiac Myocytes
Shannon, T. R. (2005) · Lecture notes in mathematics · doi:10.1007/11406501_3 · Cited by 1
Cardiovascular Activity
Vogel, H. G. (2007) · Springer eBooks · doi:10.1007/978-3-540-70995-4_2 · Cited by 1
Mitochondrial Origin of Ischemia‐Reperfusion Arrhythmias
O'Rourke, B. P. (2009) · doi:10.1002/9780470561416.ch15 · Cited by 1
Membrane Proteins | L-Type Calcium Channels in Health and Disease: The Case of Heart Failure
Katat, A. A., Segura, É., & Parent, L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819460-7.00077-3 · Cited by 1
Increased expression of Na+−Ca2+ exchanger in the myocardium. Impact on contractility and arrhythmogenesis in heart failure
Schillinger, W., & Hasenfuss, G. P. (2003) · Progress in experimental cardiology · doi:10.1007/978-1-4419-9262-8_5 · Cited by 1
Roles of Cell Junctions and the Cytoskeleton in Substrate-free Cell Sheet Engineering
Wei, Q. (2014) · doi:10.7916/d8mp51d6
Hipertrofia cardíaca patológica: estudio experimental de su modificación con el ejercicio-vías de señalización intracelular involucradas
Nolly, M. B. (2012) · El Servicio de Difusión de la Creación Intelectual (National University of La Plata) · doi:10.35537/10915/2767
Myocardial Infarction Agents
Billman, G. E., & Altschuld, R. A. (2003) · Burger's Medicinal Chemistry and Drug Discovery · doi:10.1002/0471266949.bmc043
Effects of Endurance Exercise Training on Cardiac Autonomic Regulation and Susceptibility to Sudden Cardiac Death: A Nonpharmacological Approach for the Prevention of Ventricular Fibrillation
Billman, G. E. (2009) · Wiley eBooks · doi:10.1002/9780470561416.ch20
Ion Channel Remodeling and Arrhythmias
Aiba, T., & Tomaselli, G. F. (2009) · doi:10.1002/9780470561416.ch9
Untersuchungen zur kardialen Funktion eines mRen2/SERCA2a doppelt-transgenen Hypertoniemodells
Trinks, S. (2013) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-8887
Calcium Remodeling through Different Signaling Pathways in Heart Failure: Arrhythmogenesis Studies of Pyk2, Dystrophin, and Beta-adrenergic Receptor Signaling
Lang, D. (2013) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7kk98sd
Simvastatin prevents decreased SERCA2a activity in non-ischemic heart failure in rabbits via inhibition of β-adrenergic signaling
Zou, C., Liu, Z., Qu, F., Lu, W., Han, L., Song, J., Jiang, B., & Yang, X. (2011) · Biomedicine & Aging Pathology · doi:10.1016/j.biomag.2010.09.003
Receptor-Mediated Hypertrophic Signaling Via Protein Kinase D and Histone Deacetylase 5 in Adult Myocytes
Chang, C.-W. (2012) · Loyola eCommons (Loyola University of Chicago)
Modulation of the Cardiomyocyte Hypertrophic Responses to Endothelin-1 by Adipocytes
Bairwa, S. C. (2014) · Scholarship@Western (Western University)
Sarcoplasmic reticulum calcium release function and FK binding proteins in heart failure: another piece of a complex jigsaw
Terracciano, C. M. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00207-8
SARCOPLASMIC RETICULUM CALCIUM CYCLING AND CARDIAC DISEASE
Gregory, K. N. (2005) · OhioLink ETD Center (Ohio Library and Information Network)
A nanophysiometer to study force excitation coupling in single cardiac myocytes.
Werdich, A. A. (2006) · Europe PMC (PubMed Central)
Dual V m /Ca Imaging of Premature Ventricular Contractions
Ripplinger, C. M., & Efimov, I. R. (2015) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.115.002916
Budowa i czynność serca u młodzieży wyczynowo uprawiającej sport
Siniawski, A. (2014)
Ca-Homeostasis and Heart Failure: Focus on the Biophysics of Surface Membrane Ca-Fluxes
Banach, K. (2013) · Biological and medical physics series · doi:10.1007/978-1-4614-7678-8_3
The A BC o f S olute C arriers
Quednau, B. D., Nicoll, D. A., & Philipson, K. D. (2004)
Restricted diffusion of ions regulates cardiac function
Swift, F. (2007) · NORA - Norwegian Open Research Archives
Management of Ventricular Arrhythmias in Heart Failure
Tedrow, U. B., & Stevenson, W. G. (2006) · Fundamental and clinical cardiology · doi:10.3109/9781420020168.011
SERCA2a Gene Therapy for Heart Failure
Chaanine, A. H., Yaroshinsky, A., & Hajjar, R. J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801888-0.00030-8
Histidine-Rich Ca Binding Protein and Cardiac Functions
Chen, S. (2009) · OhioLink ETD Center (Ohio Library and Information Network)
Novel Compound, 84F2, Inhibits Calmodulin Deficient RyR2
Klipp, R. C. (2017) · doi:10.15760/etd.3360
Structure-function studies of the sodium-calcium exchanger isoforms, NCX1 and NCX2
de Moissac, D. (2009) · Mspace (University of Manitoba)
Substrate Remodeling in Heart Failure
Iakovou, A., Guymer, S., & Chowdhury, R. A. (2019) · Learning materials in biosciences · doi:10.1007/978-3-030-24219-0_13
An Exercise Mimetic That Targets Nitroso-Redox Balance as a Therapeutic for Heart Disease
Shettigar, V., & Ziolo, M. T. (2019) · Springer eBooks · doi:10.1007/978-981-13-8946-7_22
Heart Failure
Su, J. B., & Berdeaux, A. (2014) · Methods and principles in medicinal chemistry · doi:10.1002/9783527679348.ch21
Novel Compound, 84F2, Inhibits Calmodulin Deficient RyR2
Klipp, R. C. (2000) · doi:10.15760/etd.5368
Calcium handling
Alexander, C., Smith, G. L., & Myles, R. C. (2022) · doi:10.1093/med/9780198766223.003.0015
Sex Differences in the Function of Cardiac Sodium-Calcium Exchanger in Physiological and Pathophysiological Settings: Implications for Cardiac Arrhythmias
Nagy, N., & Baczkó, I. (2023) · Advances in biochemistry in health and disease · doi:10.1007/978-3-031-39928-2_23
Ion Channels and Cardiac Arrhythmia in Heart Disease
Makielski, J. C., & Fozzard, H. A. (2002) · Comprehensive physiology · doi:10.1002/j.2040-4603.2002.tb00955.x
Regulation of sodium/calcium homeostasis by BacNa v gene therapy rescues cardiac dysfunction in chronic heart failure
Wu, T., Li, Y., Perelli, R. M., Siu, Y. Y., Tornatore, A., Moran, J. N., Jiang, X., DeLuca, S., Bers, D. M., Henriquez, C. S., et al. (2026) · Science Advances · doi:10.1126/sciadv.ady4551
Self-citation
Régulations monoaminergiques AMPc-dépendantes du coeur sain et pathologique
Meschin, P. (2014) · theses.fr (ABES) · doi:10.70675/e129a5b7zbf91z42b2za269z1ac8d2e6fc2a
Progrès dans la compréhension de la régulation adrénergique du couplage excitation-contraction cardiaque et des récepteurs de la ryanodine RyR₂ par la PKA de type I et FKBP12.6
Gandon-Renard, M. (2021) · doi:10.70675/4ccbb154zb1d4z42b8za0dczb89fbc06f7c4
Cardiac Calcium Signaling
Yang, H.-Q., & Du, Y. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1016951
Methods to Induce Cardiac Hypertrophy and Insufficiency
Gralinski, M., Neves, L. A. A., & Tiniakova, O. (2014) · Springer eBooks · doi:10.1007/978-3-642-27728-3_8-1

Authors: Pogwizd, S. M., Qi, M., Yuan, W., Samarel, A. M., & Bers, D. M.
Affiliations: Loyola University Chicago (US)
ORCID: Pogwizd, Steven M.
Samarel, Allen M.
Bers, Donald M.
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1999-11-26
Volume: 85
Issue: 11
Pages: 1009-1019
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/01.res.85.11.1009
OpenAlex: W2147959747
Cited by: 399
References: 49
Citations by year: 2026: 3 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 12 · 2020: 10 · 2019: 12 · 2018: 11 · 2017: 9 · 2016: 9 · 2015: 17 · 2014: 18 · 2013: 17 · 2012: 19
FWCI: 16.99
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
National Institutes of Health (5r01hl052478-05)
University of Illinois at Chicago
National Heart, Lung, and Blood Institute (HL46929, HL52478, HL30077)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords: Na+/Ca2+ exchanger, heart failure, ventricular arrhythmias, delayed afterdepolarizations, non-ischemic cardiomyopathy, sarcoplasmic reticulum calcium release, sarcoplasmic reticulum Ca2+-ATPase, caffeine-induced contracture, aortic regurgitation, aortic constriction, rabbit model, gene expression
MeSH terms: Animals, Aortic Valve Insufficiency, Arrhythmias, Cardiac, Caffeine, Calcium, Constriction, Disease Models, Animal, Gene Expression Regulation, Cardiomegaly, Heart Failure, Heart Ventricles, Molecular Weight, Myocardial Contraction, Rabbits, RNA, Messenger, Sodium, Ion Transport, Myocardial Ischemia, Sodium-Calcium Exchanger

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Upregulation of Na+/Ca2+Exchanger Expression and Function in an Arrhythmogenic Rabbit Model of Heart Failure

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks