Differential Expression of Cardiac Titin Isoforms and Modulation of Cellular Stiffness

Reversible Unfolding of Individual Titin Immunoglobulin Domains by AFM

Rief, M., Gautel, M., Oesterhelt, F., Fernández, J. M., & Gaub, H. E. (1997) · Science · doi:10.1126/science.276.5315.1109 · Cited by 3,081

Titins: Giant Proteins in Charge of Muscle Ultrastructure and Elasticity

Labeit, S., & Kolmerer, B. (1995) · Science · doi:10.1126/science.270.5234.293 · Cited by 1,257

Folding-Unfolding Transitions in Single Titin Molecules Characterized with Laser Tweezers

Kellermayer, M., Smith, S. B., Granzier, H. L., & Bustamante, C. (1997) · Science · doi:10.1126/science.276.5315.1112 · Cited by 1,217

Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments

Granzier, H. L., & Irving, T. C. (1995) · Biophysical Journal · doi:10.1016/s0006-3495(95)80278-x · Cited by 638

The NH2 Terminus of Titin Spans the Z-Disc: Its Interaction with a Novel 19-kD Ligand (T-cap) Is Required for Sarcomeric Integrity

Gregorio, C. C., Trombitás, K., Centner, T., Kolmerer, B., Stier, G., Kunke, K., Suzuki, K., Obermayr, F., Herrmann, B. G., Granzier, H. L. M., et al. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.4.1013 · Cited by 328

Muscle assembly: a titanic achievement?

Gregorio, C. C., Granzier, H., Sorimachi, H., & Labeit, S. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80003-9 · Cited by 327

Towards a Molecular Understanding of the Elasticity of Titin

Linke, W. A., Ivemeyer, M., Olivieri, N., Kolmerer, B., Rüegg, C., & Labeit, S. (1996) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0441 · Cited by 287

Myofilament-generated tension oscillations during partial calcium activation and activation dependence of the sarcomere length-tension relation of skinned cardiac cells.

Fabiato, A., & Fabiato, F. (1978) · The Journal of General Physiology · doi:10.1085/jgp.72.5.667 · Cited by 270

Titin Develops Restoring Force in Rat Cardiac Myocytes

Helmes, M., ́s, K. ́. T., & Granzier, H. (1996) · Circulation Research · doi:10.1161/01.res.79.3.619 · Cited by 260

The Giant Protein Titin

Labeit, S., Kolmerer, B., & Linke, W. A. (1997) · Circulation Research · doi:10.1161/01.res.80.2.290 · Cited by 251

Preserved single muscle fiber specific force in facioscapulohumeral muscular dystrophy

Lassche, S., Voermans, N. C., van der Pijl, R. J., van den Berg, M., Heerschap, A., van Hees, H. W. H., Küsters, B., van der Maarel, S. M., Ottenheijm, C. A. C., & van Engelen, B. G. M. (2020) · Neurology · doi:10.1212/wnl.0000000000008977 · Cited by 28

Cardiac function, structural, and electrical remodeling by microgravity exposure

Sy, M. R., Keefe, J. A., Sutton, J. P., & Wehrens, X. H. T. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00611.2022 · Cited by 28

Depressed Frank–Starling mechanism in the left ventricular muscle of the knock-in mouse model of dilated cardiomyopathy with troponin T deletion mutation ΔK210

Inoue, T., Kobirumaki-Shimozawa, F., Kagemoto, T., Fujii, T., Terui, T., Kusakari, Y., Hongo, K., Morimoto, S., Ohtsuki, I., Hashimoto, K., et al. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.07.001 · Cited by 28

Regional variation in myofilament length-dependent activation

Cazorla, O., & Lacampagne, A. (2011) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-0933-6 · Cited by 28

Myofilaments: Movers and Rulers of the Sarcomere

Lin, B. L., Song, T., & Sadayappan, S. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160026 · Cited by 38

Clinical evaluation of a matrix metalloproteinase-12 cleaved fragment of titin as a cardiovascular serological biomarker

Vassiliadis, E., Rasmussen, L. M., Byrjalsen, I., Larsen, D. V., Chaturvedi, R. C., Hosbond, S. E., Saabye, L., Diederichsen, A. C. P., Genovese, F., Duffin, K. L., et al. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-140 · Cited by 27

Section: The Elastic Vertebrate Muscle Protein Titin; Titin as a modular spring: emerging mechanisms for elasticity control by titinin cardiac physiology and pathophysiology

Granzier, H., Labeit, D., Wu, Y., & Labeit, S. (2002) · Journal of Muscle Research and Cell Motility · doi:10.1023/a:1023458406346 · Cited by 27

Titin as a modular spring: emerging mechanisms for elasticity control by titin in cardiac physiology and pathophysiology

Granzier, H., Labeit, D., Wu, Y., & Labeit, S. (2003) · Springer eBooks · doi:10.1007/978-94-010-0147-2_7 · Cited by 27

Renin overexpression leads to increased titin-based stiffness contributing to diastolic dysfunction in hypertensive mRen2 rats

Kov́acs, Á., Fülöp, G. Á., Kovács, A., Csípő, T., Bódi, B., Priksz, D., Juhász, B., Beke, L., Hendrik, Z., Méhes, G., et al. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00842.2015 · Cited by 26

CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex

Zhou, T., Fleming, J. R., Franke, B., Bogomolovas, J., Barsukov, I., Rigden, D. J., Labeit, S., & Mayans, O. M. (2016) · FEBS Letters · doi:10.1002/1873-3468.12362 · Cited by 26

Usefulness of Urinary N-Terminal Fragment of Titin to Predict Mortality in Dilated Cardiomyopathy

Yoshihisa, A., Kimishima, Y., Kiko, T., Sato, Y., Watanabe, S., Kanno, Y., Abe, S., Miyata, M., Sato, T., Suzuki, S., et al. (2018) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2018.01.046 · Cited by 26

Single-Molecule Force Spectroscopy on the N2A Element of Titin: Effects of Phosphorylation and CARP

Lanzicher, T., Zhou, T., Saripalli, C., Keschrumrus, V., Smith, J. E., Mayans, O. M., Sbaizero, O., & Granzier, H. L. M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00173 · Cited by 26

Multiscale simulations of left ventricular growth and remodeling

Sharifi, H., Mann, C. K., Rockward, A. L., Mehri, M., Mojumder, J., Lee, L.-C., Campbell, K. S., & Wenk, J. F. (2021) · Biophysical Reviews · doi:10.1007/s12551-021-00826-5 · Cited by 27

New Echocardiographic Applications for Assessing Global Left Ventricular Diastolic Function

Claessens, T. E., SUTTER, J. D., Vanhercke, D., Segers, P., & Verdonck, P. (2007) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2006.12.001 · Cited by 26

Papel da titina na modulação da função cardíaca e suas implicações fisiopatológicas

Castro‐Ferreira, R., Fontes‐Carvalho, R., Falcão‐Pires, I., & Leite-Moreira, A. F. (2011) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2011005000023 · Cited by 26

Stretch Harmonizes Sarcomere Strain Across the Cardiomyocyte

Li, J., Sundnes, J., Hou, Y., Laasmaa, M., Ruud, M., Unger, A., Kolstad, T. R., Frisk, M., Norseng, P. A., Yang, L., et al. (2023) · Circulation Research · doi:10.1161/circresaha.123.322588 · Cited by 25

Titin: roles in cardiac function and diseases

Stroik, D., Gregorich, Z. R., Raza, F., Ge, Y., & Guo, W. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1385821 · Cited by 28

Cellular and molecular signatures of alcohol-induced myopathy in women

Shenkman, B. S., Zinovyeva, O. E., Belova, S. P., Mirzoev, T. M., Vilchinskaya, N. A., Vikhlyantsev, I. M., Ulanova, A. D., Turtikova, O. V., Samkhaeva, N. D., Parfenov, V. A., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00513.2018 · Cited by 25

An activatable molecular spring reduces muscle tearing during extreme stretching

Leonard, T. R., Joumaa, V., & Herzog, W. (2010) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2010.07.016 · Cited by 25

Effect of Long-term Monotherapy with the Aldosterone Receptor Blocker Eplerenone on Cytoskeletal Proteins and Matrix Metalloproteinases in Dogs with Heart Failure

Rastogi, S., Mishra, S., Zacà, V., Alesh, I. G., Gupta, R. C., Goldstein, S., & Sabbah, H. N. (2007) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-007-6057-8 · Cited by 25

Real-time measurement of the length of a single sarcomere in rat ventricular myocytes: a novel analysis with quantum dots

Serizawa, T., Terui, T., Kagemoto, T., Mizuno, A., Shimozawa, T., Kobirumaki-Shimozawa, F., Ishiwata, S., Kurihara, S., & Fukuda, N. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00161.2011 · Cited by 25

Mechanism of the Frank–Starling law—A simulation study with a novel cardiac muscle contraction model that includes titin and troponin I

Schneider, N. S., Shimayoshi, T., Amano, A., & Matsuda, T. (2006) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.06.003 · Cited by 25

Mechanisms of TTNtv-Related Dilated Cardiomyopathy: Insights from Zebrafish Models

Santiago, C. F., Huttner, I. G., & Fatkin, D. (2021) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd8020010 · Cited by 27

Modeling sepsis, with a special focus on large animal models of porcine peritonitis and bacteremia

Vintrych, P., Al‐Obeidallah, M., Horák, J., Chvojka, J., Valešová, L., Nalos, L., Jarkovská, D., Matějovič, M., & Štengl, M. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2022.1094199 · Cited by 25

Protein kinase A–dependent modulation of Ca2+ sensitivity in cardiac and fast skeletal muscles after reconstitution with cardiac troponin

Matsuba, D., Terui, T., O‐Uchi, J., Tanaka, H., Ojima, T., Ohtsuki, I., Ishiwata, S., Kurihara, S., & Fukuda, N. (2009) · The Journal of General Physiology · doi:10.1085/jgp.200910206 · Cited by 24

Physiologic Basis and Pathophysiologic Implications of the Diastolic Properties of the Cardiac Muscle

Ferreira‐Martins, J., & Leite-Moreira, A. F. (2010) · BioMed Research International · doi:10.1155/2010/807084 · Cited by 27

Modeling AFM-Induced PEVK Extension and the Reversible Unfolding of Ig/FNIII Domains in Single and Multiple Titin Molecules

Zhang, B., & Evans, J. S. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)76040-7 · Cited by 24

Exploiting the CRISPR/Cas9 system to study alternative splicingin vivo: application to titin

Charton, K., Suel, L., Henriques, S. F., Moussu, J.-P., Bovolenta, M., Taillepierre, M., Becker, C., Lipson, K., & Richard, I. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw280 · Cited by 24

Giant Molecule Titin and Myocardial Stiffness

Hein, S., Gaasch, W. H., & Schaper, J. (2002) · Circulation · doi:10.1161/01.cir.0000031760.65615.3b · Cited by 23

Increased Autolysis ofμ-Calpain in Skeletal Muscles of Chronic Alcohol-Fed Rats

Gritsyna, Y., Salmov, N. N., Bobylev, A. G., Ulanova, A. D., Kukushkin, N. I., Podlubnaya, Z. A., & Vikhlyantsev, I. M. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13476 · Cited by 22

Through thick and thin: dual regulation of insect flight muscle and cardiac muscle compared

Bullard, B., & Pastore, A. (2019) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-019-09536-8 · Cited by 22

Synchrony of sarcomeric movement regulates left ventricular pump function in the in vivo beating mouse heart

Kobirumaki-Shimozawa, F., Shimozawa, T., Oyama, K., Baba, S., Li, J., Nakanishi, T., Terui, T., Louch, W. E., Ishiwata, S., & Fukuda, N. (2021) · The Journal of General Physiology · doi:10.1085/jgp.202012860 · Cited by 21

Stretch of Contracting Cardiac Muscle Abruptly Decreases the Rate of Phosphate Release at High and Low Calcium

Mansfield, C. A., West, T. G., Curtin, N. A., & Ferenczi, M. A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.373498 · Cited by 21

Effects of high-altitude exercise training on contractile function of rat skinned cardiomyocyte

Cazorla, O., AITMOU, Y., Goret, L., Vassort, G., Dauzat, M., Lacampagne, A., Tanguy, S., & Obert, P. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.06.020 · Cited by 21

Diastolic dysfunction and heart failure with a preserved ejection fraction: Relevance in critical illness and anaesthesia

Maharaj, R. (2012) · Journal of the Saudi Heart Association · doi:10.1016/j.jsha.2012.01.004 · Cited by 20

Porcine cardiac myocyte power output is increased after chronic exercise training

Hinken, A. C., Korte, F. S., & McDonald, K. S. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00798.2005 · Cited by 20

Passive mechanical properties of cardiac tissues in heart hypertrophy during pregnancy

Virgen‐Ortiz, A., Marin, J. L., Elizalde, A., Castro, E., Stefani, E., Toro, L., & Muñiz, J. (2009) · The Journal of Physiological Sciences · doi:10.1007/s12576-009-0047-5 · Cited by 20

Evidence for the Oligomeric State of ‘Elastic’ Titin in Muscle Sarcomeres

Houmeida, A., Baron, A., Keen, J. N., Khan, G. N., Knight, P. J., Stafford, W. F., Thirumurugan, K., Thompson, B., Tskhovrebova, L., & Trinick, J. A. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.09.030 · Cited by 20

Mechanical responses of the mechanosensitive unstructured domains in cardiac titin

Pang, S. M., Le, S., & Yan, J. (2017) · Biology of the Cell · doi:10.1111/boc.201700061 · Cited by 18

Basal oxidation of conserved cysteines modulates cardiac titin stiffness and dynamics

Herrero‐Galán, E., Domínguez, F., Martínez-Martín, I., Sánchez‐González, C., Vicente, N., Lalaguna, L., Bonzón‐Kulichenko, E., Calvo, E., González-López, E., Marcos, M. C., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102306 · Cited by 21

Hypoxia in early pregnancy induces cardiac dysfunction in adult offspring of Rattus norvegicus, a non-hypoxia-adapted species

Hauton, D. (2012) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2012.07.020 · Cited by 19

Expression and regulation of mouse SERDIN1, a highly conserved cardiac‐specific leucine‐rich repeat protein

Adameyko, I. I., Mudry, R. E., Houston-Cummings, N. R., Veselov, A. P., Gregorio, C. C., & Tevosian, S. G. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20368 · Cited by 19

The structural and functional integrities of porcine myocardium are mostly preserved by cryopreservation

Ma, W., Lee, K. H., Delligatti, C. E., Davis, M. T., Zheng, Y., Gong, H. M., Kirk, J. A., Craig, R. W., & Irving, T. C. (2023) · The Journal of General Physiology · doi:10.1085/jgp.202313345 · Cited by 18

Transmural cellular heterogeneity in myocardial electromechanics

Khokhlova, A., Balakina-Vikulova, N. A., Katsnelson, L. B., Iribe, G., & Solovyova, O. E. (2017) · The Journal of Physiological Sciences · doi:10.1007/s12576-017-0541-0 · Cited by 18

Changes in isoform composition, structure, and functional properties of titin from mongolian gerbil (Meriones unguiculatus) cardiac muscle after space flight

Vikhlyantsev, I. M., Okuneva, A. D., Shpagina, M. D., Shumilina, Y. V., Molochkov, N. V., Salmov, N. N., & Podlubnaya, Z. A. (2011) · Biochemistry (Moscow) · doi:10.1134/s0006297911120042 · Cited by 18

Titin N2A Domain and Its Interactions at the Sarcomere

Adewale, A. O., & Ahn, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147563 · Cited by 17

The N2A region of titin has a unique structural configuration

Stronczek, C., Lange, S., Bullard, B., Wolniak, S., Börgeson, E., Mayans, O. M., & Fleming, J. R. (2021) · The Journal of General Physiology · doi:10.1085/jgp.202012766 · Cited by 17

Modulation of Cardiac Function

Lim, C. C., & Sawyer, D. B. (2005) · The Journal of General Physiology · doi:10.1085/jgp.200509268 · Cited by 17

Weakness of a giant: mutations of the sarcomeric protein titin

Hein, S., & Schaper, J. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02372-9 · Cited by 17

When signalling goes wrong: pathogenic variants in structural and signalling proteins causing cardiomyopathies

Ehsan, M., Jiang, H., Thomson, K. L., & Gehmlich, K. (2017) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-017-9487-3 · Cited by 17

Unexpected Low Mechanical Stability of Titin I27 Domain at Physiologically Relevant Temperature

Yu, M., Lu, J.-H., Le, S., & Yan, J. (2021) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.1c01309 · Cited by 16

Sarcomere length affects Ca2+ sensitivity of contraction in ischemic but not non-ischemic myocardium

Tanner, B. C. W., Awinda, P. O., Agonias, K. B., Attili, S., Blair, C. A., Thompson, M. S., Walker, L. A., Kampourakis, T., & Campbell, K. S. (2022) · The Journal of General Physiology · doi:10.1085/jgp.202213200 · Cited by 17

Trends in the evolution of intronless genes in Poaceae

Chen, Y., Ma, T., Zhang, T., & Ma, L. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1065631 · Cited by 16

Effect of L-Arginine on Titin Expression in Rat Soleus Muscle After Hindlimb Unloading

Ulanova, A. D., Gritsyna, Y., Salmov, N. N., Lomonosova, Y. N., Belova, S. P., Nemirovskaya, T. L., Shenkman, B. S., & Vikhlyantsev, I. M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01221 · Cited by 16

Myocardial short-range force responses increase with age in F344 rats

Mitov, M. I., Holbrook, A. M., & Campbell, K. S. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.10.004 · Cited by 16

In indirect flight muscles Drosophila projectin has a short PEVK domain, and its NH2-terminus is embedded at the Z-band

Ayme-Southgate, A., Saide, J. D., Southgate, R., Bounaix, C., Cammarato, A., Patel, S., & Wussler, C. (2006) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-005-9031-8 · Cited by 16

Composition of titin isoforms of skeletal and cardiac muscles in pathologies

Vikhlyantsev, I. M., & Podlubnaya, Z. A. (2008) · BIOPHYSICS · doi:10.1134/s0006350908060237 · Cited by 16

A modular instrument for exploring the mechanics of cardiac myocytes

Garcia-Webb, M. G., Taberner, A. J., Hogan, N. C., & Hunter, I. W. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01055.2006 · Cited by 15

Protein Electrophoresis in Agarose Gels for Separating High Molecular Weight Proteins

Greaser, M. L., & Warren, C. M. (2012) · Methods in molecular biology · doi:10.1007/978-1-61779-821-4_10 · Cited by 15

Inhomogeneity in the response to mechanical stimulation: Cardiac muscle function and gene expression

Stones, R., Gilbert, S., Benoîst, D., & White, E. (2008) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2008.02.010 · Cited by 14

Conformational Dynamics of Titin PEVK Explored with FRET Spectroscopy

Huber, T., Grama, L., Hetényi, C., Schay, G., Fülöp, L., Penke, B., & Kellermayer, M. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2012.08.042 · Cited by 14

Solution NMR Structure of Titin N2A Region Ig Domain I83 and Its Interaction with Metal Ions

Kelly, C. M., Pace, N., Gage, M. J., & Pfuhl, M. A. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.166977 · Cited by 14

Titin and CK2α are New Intracellular Targets in Acute Insulin Application-Associated Benefits on Electrophysiological Parameters of Left Ventricular Cardiomyocytes From Insulin-Resistant Metabolic Syndrome Rats

Durak, A. T., Bitirim, C. V., & Turan, B. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-06974-2 · Cited by 12

Linagliptin prevents left ventricular stiffening by reducing titin cleavage and hypophosphorylation

Cuijpers, I., Papageorgiou, A., Carai, P., Herwig, M., Mügge, A., Klein, T., Hamdani, N., Jones, E. A. V., & Heymans, S. R. B. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16122 · Cited by 13

Elastic proteins in the flight muscle of Manduca sexta

Yuan, C.-C., Ma, W., Schemmel, P., Cheng, Y.-S., Liu, J., Tsaprailis, G., Feldman, S., Ayme-Southgate, A., & Irving, T. C. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.12.033 · Cited by 13

The link between exercise and titin passive stiffness

Lalande, S., Mueller, P. J., & Chung, C. S. (2017) · Experimental Physiology · doi:10.1113/ep086275 · Cited by 14

Hybrid duplex: a novel method to study the contractile function of heterogeneous myocardium

Protsenko, Y. L., Routkevitch, S. M., Gur'ev, V. Y., Katsnelson, L. B., Solovyova, O. E., Lookin, O. N., Балакин, А. А., Kohl, P. K., & Markhasin, V. S. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00306.2005 · Cited by 13

Integrating multi-scale data to create a virtual physiological mouse heart

Land, S., Niederer, S., Louch, W. E., Sejersted, O. M., & Smith, N. P. (2013) · Interface Focus · doi:10.1098/rsfs.2012.0076 · Cited by 13

Walking with giants: The challenges of variant impact assessment in the giant sarcomeric protein titin

Weston, T., Rees, M., Gautel, M., & Fraternali, F. (2023) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1638 · Cited by 14

The cardiomyocyte origins of diastolic dysfunction: cellular components of myocardial “stiffness”

Janssens, J. V., Raaijmakers, A. J. A., Weeks, K. L., Bell, J. R., Mellor, K. M., Curl, C. L., & Delbridge, L. M. D. (2024) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00334.2023 · Cited by 13

Sacubitril/valsartan improves diastolic left ventricular stiffness with increased titin phosphorylation via cGMP-PKG activation in diabetic mice

Furukawa, N., Matsui, H., Sunaga, H., Nagata, K., Hirayama, M., Obinata, H., Yokoyama, T., Ohno, K., Kurabayashi, M., & Koitabashi, N. (2024) · Scientific Reports · doi:10.1038/s41598-024-75757-8 · Cited by 13

Mechanically weak and highly dynamic state of mechanosensitive titin Ig domains induced by proline isomerization

Wang, Y., Ye, J., Liu, X., Zhang, Z., Shang, F., Qi, X., Zhang, Y. N., Du, J., Sun, H., Xu, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57989-y · Cited by 12

Titin isoforms are increasingly protected against oxidative modifications in developing rat cardiomyocytes

Bódi, B., Tóth, E. P., Nagy, L., Tóth, A., Mártha, L., Kov́acs, Á., Balla, G., Kovács, T., & Papp, Z. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.09.015 · Cited by 12

Real-time visualization of titin dynamics reveals extensive reversible photobleaching in human induced pluripotent stem cell-derived cardiomyocytes

Cadar, A. G., Feaster, T. K., Bersell, K. R., Wang, L., Hong, T., Balsamo, J. A., Zhang, Z., Chun, Y. W., Nam, Y., Gotthardt, M., et al. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00107.2019 · Cited by 12

Predominant synthesis of giant myofibrillar proteins in striated muscles of the long-tailed ground squirrel Urocitellus undulatus during interbout arousal

Попова, С. С., Ulanova, A. D., Gritsyna, Y., Salmov, N. N., Rogachevsky, V. V., Mikhailova, G. Z., Bobylev, A. G., Bobyleva, L. G., Yutskevich, Y., Morenkov, O. S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-72127-y · Cited by 12

Role of Neurohormonal Modulators in Heart Failure with Relatively Preserved Systolic Function

Rapp, J. A., & Gheorghiade, M. (2008) · Cardiology Clinics · doi:10.1016/j.ccl.2007.11.001 · Cited by 12

A protocol to study ex vivo mouse working heart at human-like heart rate

Feng, H., & Jin, J. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.11.011 · Cited by 12

Titin

Sutko, J. L., Publicover, N. G., & Moss, R. L. (2001) · Circulation · doi:10.1161/circ.104.14.1585 · Cited by 12

Phenotypic Plasticity of Sarcomeric Protein Mutations⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.

Marian, A. J. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.04.016 · Cited by 12

Alternative Splicing in the Heart: The Therapeutic Potential of Regulating the Regulators

Briganti, F., & Wang, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252313023 · Cited by 11

Aberrant developmental titin splicing and dysregulated sarcomere length in Thymosin β4 knockout mice

Smart, N., Riegler, J., Turtle, C. W., Lygate, C. A., McAndrew, D. J., Gehmlich, K., Dubé, K. N., Price, A. N., Muthurangu, V., Taylor, A. M., et al. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.10.010 · Cited by 11

Z‐band and M‐band titin splicing and regulation by RNA binding motif 20 in striated muscles

Chen, Z., Rexiati, M., Zhu, C., Cai, H., Stern, A., Mozdziak, P. E., Ge, Y., Ford, S. P., Nathanielsz, P. W., & Guo, W. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27328 · Cited by 11

The Oxidative Balance Orchestrates the Main Keystones of the Functional Activity of Cardiomyocytes

Bevere, M., Morabito, C., Mariggiò, M. A., & Guarnieri, S. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/7714542 · Cited by 13

Gene Expression Networks in the Murine Pulmonary Myocardium Provide Insight into the Pathobiology of Atrial Fibrillation

Boutilier, J. K., Taylor, R. L., Mann, T. S., McNamara, E. L., Hoffman, G. J., Kenny, J., Dilley, R. J., Henry, P. J., Morahan, G., Laing, N. G., et al. (2017) · G3 Genes Genomes Genetics · doi:10.1534/g3.117.044651 · Cited by 11

End‐diastolic force pre‐activates cardiomyocytes and determines contractile force: role of titin and calcium

Najafi, A., van de Locht, M., Schuldt, M., Schönleitner, P., van Willigenburg, M., Bollen, I. A. E., Goebel, M., Ottenheijm, C. A. C., van der Velden, J., Helmes, M., et al. (2019) · The Journal of Physiology · doi:10.1113/jp277985 · Cited by 11

Ultrastructural Adaptation of the Cardiomyocyte to Chronic Mitral Regurgitation

Corporan, D., Segura, A., & Padala, M. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.714774 · Cited by 11

Seasonal changes in the composition of titin isoforms in muscles of hibernating ground squirrels

Vikhlyantsev, I. M., Karaduleva, E. V., & Podlubnaya, Z. A. (2008) · BIOPHYSICS · doi:10.1134/s0006350908060249 · Cited by 11

Electrophoretic Separation of Very Large Molecular Weight Proteins in SDS Agarose

Greaser, M. L., & Warren, C. M. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8793-1_18 · Cited by 11

From Connecting Filaments to Co-Expression of Titin Isoforms

Trombitás, K., Freiburg, A., Greaser, M. L., Labeit, S., & Granzier, H. (2000) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4267-4_24 · Cited by 11

On the titin isoforms

Vikhlyantsev, I. M., & Podlubnaya, Z. A. (2006) · BIOPHYSICS · doi:10.1134/s0006350906050307 · Cited by 10

New Titin Isoforms in Skeletal Muscles of Mammals

Vikhlyantsev, I. M., Podlubnaya, Z. A., & Kozlovskaya, I. B. (2004) · Doklady Biochemistry and Biophysics · doi:10.1023/b:dobi.0000025559.14249.43 · Cited by 10

Extensible Behavior of Titin in the Miniswine Left Ventricle

LeWinter, M. M., Popper, J., McNabb, M., Nyland, L. R., Bell, S. B., & Granzier, H. L. M. (2010) · Circulation · doi:10.1161/circulationaha.109.918151 · Cited by 10

Investigating Viscoelastic Properties of Myofibrils Isolated From hiPSC-CMs Using Atomic Force Microscopy and Quasi-Linear Viscoelastic Model

Jannati, S., Maaref, Y., Tibbits, G. F., & Chiao, M. (2023) · Journal of Applied Mechanics · doi:10.1115/1.4063141 · Cited by 8

Ablation of plasma membrane Ca2+-ATPase isoform 4 prevents development of hypertrophy in a model of hypertrophic cardiomyopathy

Prasad, V., Lorenz, J. N., Lasko, V. M., Nieman, M. L., Jiang, M., Gao, X., Rubinstein, J., Wieczorek, D. F., & Shull, G. E. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.09.025 · Cited by 9

Effects of simulated ischemia on the transmural differences in the Frank–Starling relationship in isolated mouse ventricular cardiomyocytes

Khokhlova, A., Iribe, G., Yamaguchi, Y., Naruse, K., & Solovyova, O. E. (2017) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2017.05.011 · Cited by 9

Polygenic mechanisms underpinning the response to exercise‐induced muscle damage in humans: In vivo and in vitro evidence

Baumert, P., Cocks, M. S., Strauss, J. A., Shepherd, S. O., Drust, B., Lake, M., Stewart, C. E., & Erskine, R. M. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30723 · Cited by 9

Can the passive elasticity of muscle be explained directly from the mechanics of individual titin molecules?

Tskhovrebova, L., Houmeida, A., & Trinick, J. A. (2006) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-005-9034-5 · Cited by 9

Titin: The “Missing Link” of Diastole

LeWinter, M. M. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1286 · Cited by 9

Glycerol storage increases passive stiffness of muscle fibers through effects on titin extensibility

Han, S.-W., Kolb, J. S., Farman, G. P., Gohlke, J., & Granzier, H. L. M. (2025) · The Journal of General Physiology · doi:10.1085/jgp.202413729 · Cited by 8

miRNA-Orchestrated Fibroinflammatory Responses in Heart Failure with Preserved Ejection Fraction: Translational Opportunities for Precision Medicine

Micu, M. A., Cozac, D. A., & Scridon, A. (2025) · Diagnostics · doi:10.3390/diagnostics15182286 · Cited by 8

Biochemical and Mechanical Investigation of Cardiac Titin Isoforms

Neagoe, C. (2009) · heiDOK (Heidelberg University) · doi:10.11588/heidok.00009496

Gigantic variety: expression patterns of titin isoforms in striated muscles and consequences for myofibrillar passive stiffness

Neagoe, C., Opitz, C. A., Makarenko, I. I., & Linke, W. A. (2003) · Journal of Muscle Research and Cell Motility · doi:10.1023/a:1026053530766 · Cited by 197

Cardiac titin isoforms are coexpressed in the half-sarcomere and extend independently

Trombitás, K., Wu, Y., Labeit, D., Labeit, S., & Granzier, H. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.4.h1793 · Cited by 88

Gigantic variety: expression patterns of titin isoforms in striated muscles consequences for myofibrillar passive stiffness. J Muscle Res Cell Motil 2003;24:175–189

Neagoe, C., Opitz, C. A., Makarenko, I. I., & Linke, W. A. (2015)

Changes in Titin and Collagen Underlie Diastolic Stiffness Diversity of Cardiac Muscle

Wu, Y., Cazorla, O., Labeit, D., Labeit, S., & Granzier, H. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1281 · Cited by 216