The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Gap Junctions in Cardiovascular Disease
Abstract
Abstract —Connexins, the protein molecules forming gap junction channels, are reduced in number or redistributed from intercalated disks to lateral cell borders in a variety of cardiac diseases. This “gap junction remodeling” is considered to be arrhythmogenic. Using a simple model of human ventricular myocardium, we found that quantitative remodeling data extracted from the literature gave rise to only small to moderate changes in conduction velocity and the anisotropy ratio. Especially for longitudinal conduction, cytoplasmic resistivity (and thus cellular geometry) is much more important than commonly realized. None of the remodeling data gave rise to slow conduction on the order of a few centimeters per second.
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Citations
Cites
The Gap Junction Communication Channel
Kumar, N. M., & Gilula, N. B. (1996) · Cell · doi:10.1016/s0092-8674(00)81282-9 · Cited by 1,917
Connections with Connexins: the Molecular Basis of Direct Intercellular Signaling
Bruzzone, R., White, T. W., & Paul, D. L. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0001q.x · Cited by 1,302
Shaw, R. M., & Rudy, Y. (1997) · Circulation Research · doi:10.1161/01.res.81.5.727 · Cited by 670
Peters, N. S., Coromilas, J., Severs, N. J., & Wit, A. L. (1997) · Circulation · doi:10.1161/01.cir.95.4.988 · Cited by 583
Peters, N. S., Green, C. R., Poole-Wilson, P. A., & Severs, N. J. (1993) · Circulation · doi:10.1161/01.cir.88.3.864 · Cited by 439
Rapid Turnover of Connexin43 in the Adult Rat Heart
Beardslee, M. A., Laing, J. G., Beyer, E. C., & Saffitz, J. E. (1998) · Circulation Research · doi:10.1161/01.res.83.6.629 · Cited by 436
Simulation Study of Cellular Electric Properties in Heart Failure
Priebe, L., & Beuckelmann, D. J. (1998) · Circulation Research · doi:10.1161/01.res.82.11.1206 · Cited by 435
Simon, A. M., Goodenough, D. A., & Paul, D. L. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70113-7 · Cited by 385
Bruzzone, R., Haefliger, J. A., Gimlich, R. L., & Paul, D. L. (1993) · Molecular Biology of the Cell · doi:10.1091/mbc.4.1.7 · Cited by 322
Hagendorff, A., Schumacher, B., Kirchhoff, S., Lüderitz, B., & Willecke, K. (1999) · Circulation · doi:10.1161/01.cir.99.11.1508 · Cited by 309
Cited by
Electrical, contractile and structural remodeling during atrial fibrillation
Allessie, M. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00258-4 · Cited by 1,449
Role of the Autonomic Nervous System in Modulating Cardiac Arrhythmias
Shen, M. J., & Zipes, D. P. (2014) · Circulation Research · doi:10.1161/circresaha.113.302549 · Cited by 867
Models of cardiac tissue electrophysiology: Progress, challenges and open questions
Clayton, R. H., Bernus, O., Cherry, E. M., Dierckx, H., Fenton, F. H., Mirabella, L., Panfilov, A. V., Sachse, F. B., Seemann, G., & Zhang, H. (2011) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2010.05.008 · Cited by 585
Remodelling of gap junctions and connexin expression in diseased myocardium
Severs, N. J., Bruce, A. F., Dupont, E., & Rothery, S. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn133 · Cited by 560
MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets
van Rooij, E., & Olson, E. N. (2007) · Journal of Clinical Investigation · doi:10.1172/jci33099 · Cited by 553
Metadata
- Authors
- Jongsma, H. J., & Wilders, R.
- Venue
- Circulation Research
- Published
- 2000-06-23
- Volume
- 86
- Issue
- 12
- Pages
- 1193-1197
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2117689702
- Cited by
- 403
- References
- 42
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jongsma, H. J., & Wilders, R. (2000). Gap Junctions in Cardiovascular Disease. Circulation Research. https://doi.org/10.1161/01.res.86.12.1193
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
