The role of homeobox genes in vascular remodeling and angiogenesis
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Abstract —Homeodomain-containing transcription factors are critical in the regulation of cell proliferation, differentiation, and migration, and they play an important role in organogenesis and pattern formation during embryogenesis. There is evidence that some of them are oncogenes or tumor suppressors. The cardiovascular system undergoes extensive remodeling during embryogenesis and disease states such as atherosclerosis and tumor-induced angiogenesis, and homeobox genes may play an important role in regulating these processes. Recently, homeobox genes have been detected in both vascular smooth muscle and endothelial cells, and they are implicated in pathological processes such as arterial restenosis after balloon angioplasty and tumor-induced angiogenesis. The cellular function of some of these genes is beginning to be elucidated. Therefore, we briefly review what is currently known about the involvement of homeobox transcription factors in both physiological and pathological vascular remodeling and angiogenesis.
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Homeobox transcription factors regulate the expression of lineage-specific genes and control organ patterning and differentiation.
“These transcription factors regulate the expression of lineage-specific genes and control organ patterning and differentiation.39”
From Transcriptomic signatures of calcific aortic valve stenosis severity in human tricuspid and bicuspid aortic valves (2025) · cites this paper as [39]
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References 86 · Cited by 110
Research works printed but not linked: 6
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- Authors
- Gorski, D. H., & Walsh, K.
- Affiliations
- Tufts University (US)
- Venue
- Circulation Research
- Published
- 2000-11-10
- Volume
- 87
- Issue
- 10
- Pages
- 865-872
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2119470055
- Cited by
- 110
- References
- 86
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 6 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 6 · 2016: 4 · 2015: 6 · 2014: 8 · 2013: 6 · 2012: 5
- FWCI
- 0.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (AG15052)
- National Heart, Lung, and Blood Institute (R01HL050692, HL50692)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-40197, R01AR040197)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Kruppel-like factors research
- Keywords
- homeobox genes, homeodomain transcription factor, vascular remodeling, angiogenesis, tumor angiogenesis, atherosclerosis, vascular smooth muscle cells, endothelial cells, arterial restenosis, balloon angioplasty, oncogenes, tumor suppressor, embryonic cardiovascular development
- MeSH terms
- Cardiovascular System, Cell Division, Cell Movement, Endothelium, Vascular, Genes, Homeobox, Multigene Family, Muscle, Smooth, Vascular, Neovascularization, Pathologic, Transcription Factors, Homeodomain Proteins, Neovascularization, Physiologic
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