The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Endothelial Cell Apoptosis in Angiogenesis and Vessel Regression
Open accessAbstract
Abstract —The programmed form of cell death (apoptosis) is essential for normal development of multicellular organisms. In the past few years, compelling evidence accumulated that dysregulation of apoptosis can lead to embryonal death and is involved in the pathophysiology of various inflammatory and degenerative diseases. Specifically, the occurrence of endothelial cell apoptosis has deleterious effects on the development of the cardiovascular system leading to embryonal death. Moreover, endothelial cell apoptosis counteracts neovascularization in the adult organism. On the basis of these findings, one may consider the regulation of endothelial cell apoptosis as a potential therapeutic target. The induction of endothelial cell apoptosis may limit unwanted neovascularization of tumors. In contrast, the prevention of endothelial cell apoptosis may improve angiogenesis and vasculogenesis in patients with ischemia. The present work critically reviews the existing data that supports a role of endothelial cell apoptosis for vascular growth and remodeling and provides insights into the mechanisms and the potential therapeutic consequences.
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Cites
Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
O'Reilly, M. S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W. S., Flynn, E., Birkhead, J. R., Olsen, B. R., & Folkman, J. (1997) · Cell · doi:10.1016/s0092-8674(00)81848-6 · Cited by 4,486
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., & Zeiher, A. M. (1999) · Nature · doi:10.1038/21224 · Cited by 3,591
Self-citationLoss of PTEN facilitates HIF-1-mediated gene expression
Zundel, W., Schindler, C., Haas-Kogan, D., Koong, A., Kaper, F., Chen, E., Gottschalk, A. R., Ryan, H. E., Johnson, R. S., Jefferson, A. B., et al. (2000) · Genes & Development · doi:10.1101/gad.14.4.391 · Cited by 840
Kim, I., Kim, H. G., So, J.-N., Kim, J. H., Kwak, H. J., & Koh, G. Y. (2000) · Circulation Research · doi:10.1161/01.res.86.1.24 · Cited by 649
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Impairment of an endothelial NAD(+)-H2S signaling network is a reversible cause of vascular aging
Das, A., Huang, G. X., Bonkowski, M. S., Longchamp, A., Li, C., Schultz, M. B., Kim, L.-J., Osborne, B., Joshi, S., Lu, Y., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.008 · Cited by 496
A protocol for isolation and culture of human umbilical vein endothelial cells
Baudin, B., Bruneel, A., Bosselut, N., & Vaubourdolle, M. (2007) · Nature Protocols · doi:10.1038/nprot.2007.54 · Cited by 508
Temporal Profile of Angiogenesis and Expression of Related Genes in the Brain after Ischemia
Hayashi, T., Noshita, N., Sugawara, T., & Chan, P. H. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000041283.53351.cb · Cited by 391
Mechanisms of Vessel Pruning and Regression
Korn, C., & Augustin, H. G. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.06.004 · Cited by 297
Corbacho, A., Martinez De La Escalera, G., & Clapp, C. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1730219 · Cited by 256
Metadata
- Authors
- Dimmeler, S., & Zeiher, A. M.
- Venue
- Circulation Research
- Published
- 2000-09-15
- Volume
- 87
- Issue
- 6
- Pages
- 434-439
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2143340268
- Cited by
- 425
- References
- 4
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
