The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Microsatellite Instability of Endothelial Cell Growth and Apoptosis Genes Within Plexiform Lesions in Primary Pulmonary Hypertension
Abstract
Abstract —Primary pulmonary hypertension (PPH) is a frequently fatal disease whose pathobiology is poorly understood. Monoclonal endothelial cell growth is present within plexiform lesions of patients with PPH but not secondary PH because of congenital heart malformations. We hypothesized that endothelial cells within PPH plexiform lesions harbor mutations permissive for clonal cell growth. We found that endothelial cells in PPH plexiform lesions demonstrated microsatellite instability within the human MutS Homolog 2 gene (10 of 20 lesions) and displayed microsatellite site mutations and reduced protein expression of transforming growth factor-β receptor type II (6 of 19 lesions) and Bax (4 of 19 lesions). These results suggest that, in PPH, proliferated endothelial cells have genetic alterations associated with microsatellite instability and concomitant perturbation of growth and apoptosis gene expression akin to neoplasia. The full text of this article is available at http://www.circresaha.org.
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Inflammation, Growth Factors, and Pulmonary Vascular Remodeling
Hassoun, P. M., Mouthon, L., Barberà, J. A., Eddahibi, S., Flores, S. C., Grimminger, F., Jones, P. L., Maitland, M. L., Michelakis, E. D., Morrell, N. W., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.04.006 · Cited by 710
Self-citationPathologic assessment of vasculopathies in pulmonary hypertension
Pietra, G. G., Capron, F., Stewart, S., Leone, O., Humbert, M., Robbins, I. M., Reid, L. M., & Tuder, R. M. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.02.033 · Cited by 709
Self-citationAtkinson, C., Stewart, S., Upton, P. D., Machado, R., Thomson, J. R., Trembath, R. C., & Morrell, N. W. (2002) · Circulation · doi:10.1161/01.cir.0000012754.72951.3d · Cited by 697
Relevant Issues in the Pathology and Pathobiology of Pulmonary Hypertension
Tuder, R. M., Archer, S. L., Dorfmüller, P., Erzurum, S. C., Guignabert, C., Michelakis, E., Rabinovitch, M., Schermuly, R., Stenmark, K. R., & Morrell, N. W. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.10.025 · Cited by 585
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Metadata
- Authors
- Yeager, M. E., Halley, G. R., Golpon, H. A., Voelkel, N. F., & Tuder, R. M.
- Venue
- Circulation Research
- Published
- 2001-01-19
- Volume
- 88
- Issue
- 1
- Pages
- E2-E11
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2161607998
- Cited by
- 286
- References
- 44
- FWCI
- 15.72
- Type
- journal article
- Language
- en
- Open access
- closed
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