The DOI matches its Crossref record.
Moderate homocysteinemia--a possible risk factor for arteriosclerotic cerebrovascular disease.
Open accessAbstract
Highly elevated concentrations of homocysteine measured as homocysteine or cysteine-homocysteine mixed disulfide (MDS) are found in plasma and urine in subjects with inherited abnormalities of the methionine metabolism. These subjects have a high incidence of arteriosclerotic vascular complications during childhood. Homocysteine causes endothelial cell injury and cell detachment that initiates the development of arteriosclerosis. The present study demonstrates a significantly elevated mean plasma MDS concentration in 19 patients with arteriosclerotic cerebrovascular disease compared to 17 controls. Our findings suggest that moderate homocysteinemia might be a risk factor for arteriosclerotic cerebrovascular disease.
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Citations
Cited by
Homocysteine and Cardiovascular Disease
Refsum, H., Ueland, P. M., Nygård, O., & Vollset, S. E. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.31 · Cited by 2,180
Homocysteine and Risk of Ischemic Heart Disease and Stroke: A Meta-analysis
Homocysteine Studies Collaboration (2002) · JAMA · doi:10.1001/jama.288.16.2015 · Cited by 2,059
Toole, J. F., Malinow, M. R., Chambless, L. E., Spence, J. D., Pettigrew, L. C., Howard, V. J., Sides, E. G., Wang, C.-H., & Stampfer, M. (2004) · JAMA · doi:10.1001/jama.291.5.565 · Cited by 1,391
Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum
Ubbink, J. B., Hayward Vermaak, W. J., & Bissbort, S. (1991) · Journal of Chromatography B: Biomedical Sciences and Applications · doi:10.1016/0378-4347(91)80407-4 · Cited by 678
Homocyst(e)ine Decreases Bioavailable Nitric Oxide by a Mechanism Involving Glutathione Peroxidase
Upchurch, G. R., Welch, G. N., Fabian, A. J., Freedman, J. E., Johnson, J. L., Keaney, J. F., & Loscalzo, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.17012 · Cited by 668
Metadata
- Authors
- Brattstrom, L. E., Hardebo, J. E., & Hultberg, B. L.
- Venue
- Stroke
- Published
- 1984-11
- Volume
- 15
- Issue
- 6
- Pages
- 1012-1016
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2123507435
- Cited by
- 282
- References
- 0
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Brattstrom, L. E., Hardebo, J. E., & Hultberg, B. L. (1984). Moderate homocysteinemia--a possible risk factor for arteriosclerotic cerebrovascular disease. Stroke. https://doi.org/10.1161/01.str.15.6.1012
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
