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Cited by 578

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Investigating the Relationship Between Stroke and Obstructive Sleep Apnea

Dyken, Mark E., Somers, Virend K., Yamada, Thoru, Ren, Zong-Ying, Zimmerman, M. Bridget·1996·Stroke

Abstract

Background and Purpose We aimed to prospectively determine whether the incidence of obstructive sleep apnea in patients with recent stroke was significantly different from that of a sex- and age-matched control group with no major medical problems. Methods We prospectively performed overnight polysomnography in 24 patients with a recent stroke (13 men and 11 women; mean age [±SD], 64.6±10.4 years) and 27 subjects without stroke (13 men and 14 women; mean age, 61.6±8.8 years). Patients with either ischemic or hemorrhagic stroke were entered into this study. Polysomnographic evaluations were performed within approximately 2 to 5 weeks after each patient’s stroke. Results Obstructive sleep apnea was found in 10 of 13 men with stroke (77%) and in only 3 of 13 male subjects without stroke (23%) ( P =.0169). Seven of 11 women with stroke (64%) had obstructive sleep apnea, while only 2 of 14 female subjects without stroke (14%) had obstructive sleep apnea ( P =.0168). For men with stroke, the mean apnea/hypopnea index (±SE) was 21.5±4.2 events per hour, while for male subjects without stroke it was 4.8±1.8 events per hour ( P =.0014). For women with stroke the mean apnea/hypopnea index was 31.6±8.8 events per hour, while for female subjects without stroke it was 2.9±1.6 events per hour ( P =.0024). The 4-year mortality for patients with stroke was 20.8%. All patients with stroke who died had obstructive sleep apnea. Conclusions Patients with stroke have an increased incidence of obstructive sleep apnea compared with normal sex- and age-matched control subjects. Hypoxia and hemodynamic responses to obstructive sleep apnea may have predisposed these patients to stroke.

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Metadata

Authors
Dyken, M. E., Somers, V. K., Yamada, T., Ren, Z.-Y., & Zimmerman, M. B.
Venue
Stroke
Published
1996-03
Volume
27
Issue
3
Pages
401-407
ISSN
  • 0039-2499 (ISSN-L)
  • 1524-4628
OpenAlex
W2115730526
Cited by
578
References
26
FWCI
7.58
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Investigating the Relationship Between Stroke and Obstructive Sleep Apnea. https://app.cochat.ai/papers/10.1161/01.str.27.3.401
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Dyken, M. E., Somers, V. K., Yamada, T., Ren, Z.-Y., & Zimmerman, M. B. (1996). Investigating the Relationship Between Stroke and Obstructive Sleep Apnea. Stroke. https://doi.org/10.1161/01.str.27.3.401

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.