The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Endothelial Outgrowth Cells Are Not Derived From CD133 + Cells or CD45 + Hematopoietic Precursors
Open accessAbstract
Objective— Two types of endothelial progenitor cells (EPCs), early EPCs and late EPCs (also called endothelial outgrowth cells [EOCs]), were described in vitro previously. In this report, we dissect the phenotype of the precursor(s) that generate these cell types with focus on the markers CD34, CD133, and vascular endothelial growth factor receptor-2 (VEGFR2) that have been used to identify putative circulating endothelial precursors. We also included CD45 in the analysis to assess the relation between CD34 + hematopoietic progenitors (HPC), CD34 + endothelial precursors, and both in vitro generated EPC types. Addressing this issue might lead to a better understanding of the lineage and phenotype of the precursor(s) that give rise to both cell types in vitro and may contribute to a consensus on their flowcytometric enumeration. Methods and Results— Using cell sorting of human cord blood (UCB) and bone marrow (BM) cells, we demonstrate that EOC generating precursors are confined to a small CD34 + CD45 − cell fraction, but not to the CD34 + CD45 + HPC fraction, nor any other CD45 + subpopulation. CD34 + CD45 + HPC generated monocytic cells that displayed characteristics typical for early EPCs. Phenotypic analysis showed that EOC generating CD34 + CD45 − cells express VEGFR2 but not CD133, whereas CD34 + CD45 + HPC express CD133 as expected, but not VEGFR2. Conclusion— EOCs are not derived from CD133 + cells or CD45 + hematopoietic precursors.
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Cites
Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G., & Isner, J. M. (1997) · Science · doi:10.1126/science.275.5302.964 · Cited by 8,725
Peichev, M., Naiyer, A. J., Pereira, D., Zhu, Z., Lane, W. J., Williams, M., Oz, M. C., Hicklin, D. J., Witte, L., Moore, M. A. S., et al. (2000) · Blood · doi:10.1182/blood.v95.3.952.003k27_952_958 · Cited by 2,277
Circulating endothelial progenitor cells and cardiovascular outcomes
Werner, N., Kosiol, S., Schiegl, T., Ahlers, P., Walenta, K., Link, A., Böhm, M., & Nickenig, G. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043814 · Cited by 2,048
AC133, a Novel Marker for Human Hematopoietic Stem and Progenitor Cells
Yin, A. H., Miraglia, S., Zanjani, E. D., Almeida-Porada, G., Ogawa, M., Leary, A. G., Olweus, J., Kearney, J., & Buck, D. W. (1997) · Blood · doi:10.1182/blood.v90.12.5002 · Cited by 1,822
Evidence for Circulating Bone Marrow-Derived Endothelial Cells
Shi, Q., Rafii, S., Wu, M. H.-D., Wijelath, E. S., Yu, C., Ishida, A., Fujita, Y., Kothari, S., Mohle, R., Sauvage, L. R., et al. (1998) · Blood · doi:10.1182/blood.v92.2.362 · Cited by 1,695
Rehman, J., Li, J., Orschell, C. M., & March, K. L. (2003) · Circulation · doi:10.1161/01.cir.0000058702.69484.a0 · Cited by 1,686
Ingram, D. A., Mead, L. E., Tanaka, H., Meade, V., Fenoglio, A., Mortell, K., Pollok, K., Ferkowicz, M. J., Gilley, D., & Yoder, M. C. (2004) · Blood · doi:10.1182/blood-2004-04-1396 · Cited by 1,533
Origins of circulating endothelial cells and endothelial outgrowth from blood
Lin, Y., Weisdorf, D. J., Solovey, A., & Hebbel, R. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8071 · Cited by 1,531
Yoder, M. C., Mead, L. E., Prater, D., Krier, T. R., Mroueh, K. N., Li, F., Krasich, R., Temm, C. J., Prchal, J. T., & Ingram, D. A. (2007) · Blood · doi:10.1182/blood-2006-08-043471 · Cited by 1,477
In vitro differentiation of endothelial cells from AC133-positive progenitor cells
Gehling, U. M., Ergün, S., Schumacher, U., Wagener, C., Pantel, K., Otte, M., Schuch, G., Schafhausen, P., Mende, T., Kilic, N., et al. (2000) · Blood · doi:10.1182/blood.v95.10.3106 · Cited by 1,015
Cited by
Assessing Identity, Phenotype, and Fate of Endothelial Progenitor Cells
Hirschi, K. K., Ingram, D. A., & Yoder, M. C. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.155960 · Cited by 746
Identification of Endothelial Cells and Progenitor Cell Subsets in Human Peripheral Blood
Estes, M. L., Mund, J. A., Ingram, D. A., & Case, J. (2010) · Current Protocols in Cytometry · doi:10.1002/0471142956.cy0933s52 · Cited by 87
Metadata
- Authors
- Timmermans, F., Van Hauwermeiren, F., De Smedt, M., Raedt, R., Plasschaert, F., De Buyzere, M. L., Gillebert, T. C., Plum, J., & Vandekerckhove, B.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2007-07
- Volume
- 27
- Issue
- 7
- Pages
- 1572-1579
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2110419512
- Cited by
- 355
- References
- 22
- FWCI
- 13.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Timmermans, F., Van Hauwermeiren, F., De Smedt, M., Raedt, R., Plasschaert, F., De Buyzere, M. L., Gillebert, T. C., Plum, J., & Vandekerckhove, B. (2007). Endothelial Outgrowth Cells Are Not Derived From CD133 + Cells or CD45 + Hematopoietic Precursors. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/atvbaha.107.144972
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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