The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Gender Differences in Endothelial Progenitor Cells and Cardiovascular Risk Profile: The Role of Female Estrogens
Open accessAbstract
Objective— Endothelial progenitor cells (EPCs) participate in vascular homeostasis and angiogenesis. The aim of the present study was to explore EPC number and function in relation to cardiovascular risk, gender, and reproductive state. Methods and Results— As measured by flow-cytometry in 210 healthy subjects, CD34 + KDR + EPCs were higher in fertile women than in men, but were not different between postmenopausal women and age-matched men. These gender gradients mirrored differences in cardiovascular profile, carotid intima-media thickness, and brachial artery flow-mediated dilation. Moreover, EPCs and soluble c-kit ligand varied in phase with menstrual cycle in ovulatory women, suggesting cyclic bone marrow mobilization. Experimentally, hysterectomy in rats was followed by an increase in circulating EPCs. EPCs cultured from female healthy donors were more clonogenic and adherent than male EPCs. Treatment with 17β-estradiol stimulated EPC proliferation and adhesion, via estrogen receptors. Finally, we show that the proangiogenic potential of female EPCs was higher than that of male EPCs in vivo. Conclusions— EPCs are mobilized cyclically in fertile women, likely to provide a pool of cells for endometrial homeostasis. The resulting higher EPC levels in women than in men reflect the cardiovascular profile and could represent one mechanism of protection in the fertile female population.
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Cites
O'Leary, D. H., Polak, J. F., Kronmal, R. A., Manolio, T. A., Burke, G. L., & Wolfson, S. K. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901073400103 · Cited by 4,685
Circulating endothelial progenitor cells and cardiovascular outcomes
Werner, N., Kosiol, S., Schiegl, T., Ahlers, P., Walenta, K., Link, A., Böhm, M., & Nickenig, G. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043814 · Cited by 2,048
Fadini, G. P., Coracina, A., Baesso, I., Agostini, C., Tiengo, A., Avogaro, A., & Vigili de Kreutzenberg, S. (2006) · Stroke · doi:10.1161/01.str.0000236064.19293.79 · Cited by 205
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Cited by
Balistreri, C. R., Buffa, S., Pisano, C., Lio, D., Ruvolo, G., & Mazzesi, G. (2015) · BioMed Research International · doi:10.1155/2015/835934 · Cited by 76
Levels of circulating angiogenic cells are not altered in women with endometriosis
Webster, K. E., Kennedy, S. H., & Becker, C. M. (2013) · Human Reproduction · doi:10.1093/humrep/des454 · Cited by 7
Metadata
- Authors
- Fadini, G. P., de Kreutzenberg, S., Albiero, M., Coracina, A., Pagnin, E., Baesso, I., Cignarella, A., Bolego, C., Plebani, M., Nardelli, G. B., Sartore, S., Agostini, C., & Avogaro, A.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2008-05
- Volume
- 28
- Issue
- 5
- Pages
- 997-1004
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2155042297
- Cited by
- 185
- References
- 3
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Gender Differences in Endothelial Progenitor Cells and Cardiovascular Risk Profile: The Role of Female Estrogens. https://app.cochat.ai/papers/10.1161/atvbaha.107.159558
- The paper
- Fadini, G. P., de Kreutzenberg, S., Albiero, M., Coracina, A., Pagnin, E., Baesso, I., Cignarella, A., Bolego, C., Plebani, M., Nardelli, G. B., Sartore, S., Agostini, C., & Avogaro, A. (2008). Gender Differences in Endothelial Progenitor Cells and Cardiovascular Risk Profile: The Role of Female Estrogens. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/atvbaha.107.159558
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
