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Cited by 215

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Natural Killer T Cells Are Involved in Adipose Tissues Inflammation and Glucose Intolerance in Diet-Induced Obese Mice

Open access
Ohmura, Kazue, Ishimori, Naoki, Ohmura, Yoshinori, Tokuhara, Satoshi, Nozawa, Atsushi, Horii, Shunpei, Andoh, Yasuhiro, Fujii, Satoshi, Iwabuchi, Kazuya, Onoé, Kazunori, Tsutsui, Hiroyuki·2010·Arteriosclerosis, Thrombosis, and Vascular Biology
DOI 10.1161/atvbaha.109.198614
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Abstract

Background— Macrophage and lymphocyte infiltration in adipose tissue may contribute to the pathogenesis of obesity-mediated metabolic disorders. Natural killer T (NKT) cells, which integrate proinflammatory cytokines, have been demonstrated in the atherosclerotic lesions and in visceral adipose tissue. Objective— To determine whether NKT cells are involved in glucose intolerance and adipose tissue inflammation in diet-induced obese mice. Methods and Results— To determine whether NKT cells are involved in the development of glucose intolerance, male β 2 -microglobulin knockout (KO) mice lacking NKT cells and C57BL/6J (wild-type) mice were fed with a high-fat diet (HFD) for 13 weeks. Body weight and visceral obesity were comparable between wild-type and KO mice. However, macrophage infiltration was reduced in adipose tissue and glucose intolerance was significantly ameliorated in KO mice. To further confirm that NKT cells are involved in these abnormalities, α-galactosylceramide, 0.1 μg/g body weight, which specifically activates NKT cells, was administered after 13 weeks of HFD feeding. α-Galactosylceramide significantly exacerbated glucose intolerance and macrophage infiltration as well as cytokine gene expression in adipose tissue. Conclusion— NKT cells play a crucial role in the development of adipose tissue inflammation and glucose intolerance in diet-induced obesity.

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Metadata

Authors
Ohmura, K., Ishimori, N., Ohmura, Y., Tokuhara, S., Nozawa, A., Horii, S., Andoh, Y., Fujii, S., Iwabuchi, K., Onoé, K., & Tsutsui, H.
Venue
Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2010-02
Volume
30
Issue
2
Pages
193-199
ISSN
  • 1079-5642 (ISSN-L)
  • 1524-4636
DOI
10.1161/atvbaha.109.198614
OpenAlex
W2131632285
Cited by
215
References
9
FWCI
13.37
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Natural Killer T Cells Are Involved in Adipose Tissues Inflammation and Glucose Intolerance in Diet-Induced Obese Mice. https://app.cochat.ai/papers/10.1161/atvbaha.109.198614
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Ohmura, K., Ishimori, N., Ohmura, Y., Tokuhara, S., Nozawa, A., Horii, S., Andoh, Y., Fujii, S., Iwabuchi, K., Onoé, K., & Tsutsui, H. (2010). Natural Killer T Cells Are Involved in Adipose Tissues Inflammation and Glucose Intolerance in Diet-Induced Obese Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/atvbaha.109.198614

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.