CoChat
Sign Up
Cited by 367Atherosclerosis and Cardiovascular DiseasesPhagocytosis and Immune RegulationNeuroinflammation and Neurodegeneration Mechanisms

Nonclassical Patrolling Monocyte Function in the Vasculature

Open access
Thomas, Graham, Tacke, Robert, Hedrick, Catherine C., Hanna, Richard N.·2015·Arteriosclerosis, Thrombosis, and Vascular Biology
DOI 10.1161/atvbaha.114.304650PMC PMC4441550
Open this paper in CoChat — free accountOpen PDF

Abstract

Nonclassical patrolling monocytes are characterized by their unique ability to actively patrol the vascular endothelium under homeostatic and inflammatory conditions. Patrolling monocyte subsets (CX3CR1 high Ly6C − in mouse and CX3CR1 high CD14 dim CD16 + in humans) are distinct from the classical monocyte subsets (CCR2 high Ly6C + in mouse and CCR2 high CD14 + CD16 − in humans) and exhibit unique functions in the vasculature and inflammatory disease. Patrolling monocytes function in several disease settings to remove damaged cells and debris from the vasculature and have been associated with wound healing and the resolution of inflammation in damaged tissues. This review highlights the unique functions of these patrolling monocytes in the vasculature and during inflammation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1161/atvbaha.114.304650

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Non-classical monocytes are known as patrolling monocytes, named for their role in surveilling the vasculature and crossing the blood brain barrier to remove damaged tissue, including amyloid plaques.

    “Non-classical monocytes are known as patrolling monocytes, named for their role in surveilling the vasculature and crossing the blood brain barrier to remove damaged tissue, including amyloid plaques.39–41”

    From TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice (2025) · cites this paper as [41]

    The Introduction identifies nonclassical monocytes as patrolling cells, and “Neurological diseases and damage” says they patrol brain vasculature and remove amyloid beta from it. That section does not say they cross the blood-brain barrier to remove damaged tissue or amyloid plaques; it instead describes the barrier as maintained by perivascular macrophages. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

No citation lists for this paper

No citation lists for this paper yet — checked again daily.

References 98 · Cited by 367

Research works printed but not linked: 91

  1. [1]Swirski FK Monocyte recruitment and macrophage proliferation in atherosclerosis Kardiol Pol 2014 72 311 314 24526549
  2. [2]Swirski FK Nahrendorf M Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure Science 2013 339 161 166 23307733 PMC3891792
  3. [3]Swirski FK Libby P Aikawa E Alcaide P Luscinskas FW Weissleder R Pittet MJ Ly-6chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata J Clin Invest 2007 117 195 205 17200719 PMC1716211
  4. [4]Smith JD Trogan E Ginsberg M Grigaux C Tian J Miyata M Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein e Proc Natl Acad Sci U S A 1995 92 8264 8268 7667279 PMC41137
  5. [5]Combadière C Potteaux S Rodero M Simon T Pezard A Esposito B Merval R Proudfoot A Tedgui A Mallat Z Combined inhibition of ccl2, cx3cr1, and ccr5 abrogates ly6c(hi) and ly6c(lo) monocytosis and almost abolishes atherosclerosis in hypercholesterolemic mice Circulation 2008 117 1649 1657 18347211
  6. [6]Lessner SM Prado HL Waller EK Galis ZS Atherosclerotic lesions grow through recruitment and proliferation of circulating monocytes in a murine model Am J Pathol 2002 160 2145 2155 12057918 PMC1850830
  7. [7]Boring L Gosling J Cleary M Charo IF Decreased lesion formation in ccr2−/− mice reveals a role for chemokines in the initiation of atherosclerosis Nature 1998 394 894 897 9732872
  8. [8]van Amerongen MJ Harmsen MC van Rooijen N Petersen AH van Luyn MJ Macrophage depletion impairs wound healing and increases left ventricular remodeling after myocardial injury in mice Am J Pathol 2007 170 818 829 17322368 PMC1864893
  9. [9]Geissmann F Jung S Littman D Blood monocytes consist of two principal subsets with distinct migratory properties Immunity 2003 19 71 82 12871640
  10. [10]Cros J Cagnard N Woollard K Patey N Zhang SY Senechal B Puel A Biswas SK Moshous D Picard C Jais JP D’Cruz D Casanova JL Trouillet C Geissmann F Human cd14dim monocytes patrol and sense nucleic acids and viruses via tlr7 and tlr8 receptors Immunity 2010 33 375 386 20832340 PMC3063338
  11. [11]Randolph GJ Emigration of monocyte-derived cells to lymph nodes during resolution of inflammation and its failure in atherosclerosis Curr Opin Lipidol 2008 19 462 468 18769227 PMC2652166
  12. [12]Tacke F Ginhoux F Jakubzick C van Rooijen N Merad M Randolph G Immature monocytes acquire antigens from other cells in the bone marrow and present them to t cells after maturing in the periphery J Exp Med 2006 203 583 597 16492803 PMC2118235
  13. [13]Ziegler-Heitbrock L Ancuta P Crowe S Dalod M Grau V Hart DN Leenen PJ Liu YJ MacPherson G Randolph GJ Scherberich J Schmitz J Shortman K Sozzani S Strobl H Zembala M Austyn JM Lutz MB Nomenclature of monocytes and dendritic cells in blood Blood 2010 116 e74 80 20628149
  14. [14]Passlick B Flieger D Ziegler-Heitbrock HW Identification and characterization of a novel monocyte subpopulation in human peripheral blood Blood 1989 74 2527 2534 2478233
  15. [15]Tacke F Randolph GJ Migratory fate and differentiation of blood monocyte subsets Immunobiology 2006 211 609 618 16920499
  16. [16]Carlin LM Stamatiades EG Auffray C Hanna RN Glover L Vizcay-Barrena G Hedrick CC Cook HT Diebold S Geissmann F Nr4a1-dependent ly6c(low) monocytes monitor endothelial cells and orchestrate their disposal Cell 2013 153 362 375 23582326 PMC3898614
  17. [17]Auffray C Fogg D Garfa M Elain G Join-Lambert O Kayal S Sarnacki S Cumano A Lauvau G Geissmann F Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior Science 2007 317 666 670 17673663
  18. [18]Audoy-Rémus J Richard JF Soulet D Zhou H Kubes P Vallières L Rod-shaped monocytes patrol the brain vasculature and give rise to perivascular macrophages under the influence of proinflammatory cytokines and angiopoietin-2 J Neurosci 2008 28 10187 10199 18842879 PMC6671016
  19. [19]Tacke F Alvarez D Kaplan T Jakubzick C Spanbroek R Llodra J Garin A Liu J Mack M van Rooijen N Lira S Habenicht A Randolph G Monocyte subsets differentially employ ccr2, ccr5, and cx3cr1 to accumulate within atherosclerotic plaques J Clin Invest 2007 117 185 194 17200718 PMC1716202
  20. [21]Varol C Landsman L Fogg DK Greenshtein L Gildor B Margalit R Kalchenko V Geissmann F Jung S Monocytes give rise to mucosal, but not splenic, conventional dendritic cells J Exp Med 2007 204 171 180 17190836 PMC2118434
  21. [22]van Furth R Cohn ZA The origin and kinetics of mononuclear phagocytes J Exp Med 1968 128 415 435 5666958 PMC2138527
  22. [24]Fogg D Sibon C Miled C Jung S Aucouturier P Littman D Cumano A Geissmann F A clonogenic bone marrow progenitor specific for macrophages and dendritic cells Science 2006 311 83 87 16322423
  23. [25]Hettinger J Richards DM Hansson J Barra MM Joschko AC Krijgsveld J Feuerer M Origin of monocytes and macrophages in a committed progenitor Nat Immunol 2013 14 821 830 23812096
  24. [26]Varol C Yona S Jung S Origins and tissue-context-dependent fates of blood monocytes Immunol Cell Biol 2009 87 30 38 19048016
  25. [27]Alder JK Georgantas RW Hildreth RL Kaplan IM Morisot S Yu X McDevitt M Civin CI Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo J Immunol 2008 180 5645 5652 18390749 PMC3074963
  26. [28]Kurotaki D Osato N Nishiyama A Yamamoto M Ban T Sato H Nakabayashi J Umehara M Miyake N Matsumoto N Nakazawa M Ozato K Tamura T Essential role of the irf8-klf4 transcription factor cascade in murine monocyte differentiation Blood 2013 121 1839 1849 23319570 PMC3591803
  27. [29]Hanna RN Carlin LM Hubbeling HG Nackiewicz D Green AM Punt JA Geissmann F Hedrick CC The transcription factor nr4a1 (nur77) controls bone marrow differentiation and the survival of ly6c-monocytes Nat Immunol 2011 12 778 785 21725321 PMC3324395
  28. [30]Hanna RN Shaked I Hubbeling HG Punt JA Wu R Herrley E Zaugg C Pei H Geissmann F Ley K Hedrick CC Nr4a1 (nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis Circ Res 2012 110 416 427 22194622 PMC3309661
  29. [31]Serbina NV Jia T Hohl TM Pamer EG Monocyte-mediated defense against microbial pathogens Annu Rev Immunol 2008 26 421 452 18303997 PMC2921669
  30. [32]Tsou CL Peters W Si Y Slaymaker S Aslanian AM Weisberg SP Mack M Charo IF Critical roles for ccr2 and mcp-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites J Clin Invest 2007 117 902 909 17364026 PMC1810572
  31. [33]Weber C Belge KU von Hundelshausen P Draude G Steppich B Mack M Frankenberger M Weber KS Ziegler-Heitbrock HW Differential chemokine receptor expression and function in human monocyte subpopulations J Leukoc Biol 2000 67 699 704 10811011
  32. [34]Lewis ND Haxhinasto SA Anderson SM Stefanopoulos DE Fogal SE Adusumalli P Desai SN Patnaude LA Lukas SM Ryan KR Slavin AJ Brown ML Modis LK Circulating monocytes are reduced by sphingosine-1-phosphate receptor modulators independently of s1p3 J Immunol 2013 190 3533 3540 23436932
  33. [35]Cyster JG Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs Annu Rev Immunol 2005 23 127 159 15771568
  34. [36]Awojoodu AO Ogle ME Sefcik LS Bowers DT Martin K Brayman KL Lynch KR Peirce-Cottler SM Botchwey E Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis Proc Natl Acad Sci U S A 2013 110 13785 13790 23918395 PMC3752259
  35. [37]Debien E Mayol K Biajoux V Daussy C De Aguero MG Taillardet M Dagany N Brinza L Henry T Dubois B Kaiserlian D Marvel J Balabanian K Walzer T S1pr5 is pivotal for the homeostasis of patrolling monocytes Eur J Immunol 2013 43 1667 1675 23519784
  36. [38]Kuwano Y Spelten O Zhang H Ley K Zarbock A Rolling one- or p-selectin induces the extended but not high-affinity conformation of lfa-1 in neutrophils Blood 2010 116 617 624 20445017 PMC3324292
  37. [39]Hentzen ER Neelamegham S Kansas GS Benanti JA McIntire LV Smith CW Simon SI Sequential binding of cd11a/cd18 and cd11b/cd18 defines neutrophil capture and stable adhesion to intercellular adhesion molecule-1 Blood 2000 95 911 920 10648403
  38. [40]Moser M Legate KR Zent R Fässler R The tail of integrins, talin, and kindlins Science 2009 324 895 899 19443776
  39. [42]Jakubzick C Tacke F Ginhoux F Wagers AJ van Rooijen N Mack M Merad M Randolph GJ Blood monocyte subsets differentially give rise to cd103+ and cd103− pulmonary dendritic cell populations J Immunol 2008 180 3019 3027 18292524
  40. [43]Ge S Hertel B Susnik N Rong S Dittrich AM Schmitt R Haller H von Vietinghoff S Interleukin 17 receptor a modulates monocyte subsets and macrophage generation in vivo PLoS One 2014 9 e85461 24454873 PMC3893198
  41. [44]Bhattacharya S Ray RM Johnson LR Stat3-mediated transcription of bcl-2, mcl-1 and c-iap2 prevents apoptosis in polyamine-depleted cells Biochem J 2005 392 335 344 16048438 PMC1316269
  42. [45]Heimbeck I Hofer TP Eder C Wright AK Frankenberger M Marei A Boghdadi G Scherberich J Ziegler-Heitbrock L Standardized single-platform assay for human monocyte subpopulations: Lower cd14+cd16++ monocytes in females Cytometry A 2010 77 823 830 20662093
  43. [46]Steppich B Dayyani F Gruber R Lorenz R Mack M Ziegler-Heitbrock HW Selective mobilization of cd14(+)cd16(+) monocytes by exercise Am J Physiol Cell Physiol 2000 279 C578 586 10942707
  44. [47]Dimitrov S Lange T Born J Selective mobilization of cytotoxic leukocytes by epinephrine J Immunol 2010 184 503 511 19949113
  45. [49]Woollard KJ Geissmann F Monocytes in atherosclerosis: Subsets and functions Nat Rev Cardiol 2010 7 77 86 20065951 PMC2813241
  46. [50]Ingersoll MA Spanbroek R Lottaz C Gautier EL Frankenberger M Hoffmann R Lang R Haniffa M Collin M Tacke F Habenicht AJ Ziegler-Heitbrock L Randolph GJ Comparison of gene expression profiles between human and mouse monocyte subsets Blood 2010 115 e10 19 19965649 PMC2810986
  47. [51]Szaflarska A Baj-Krzyworzeka M Siedlar M Weglarczyk K Ruggiero I Hajto B Zembala M Antitumor response of cd14+/cd16+ monocyte subpopulation Exp Hematol 2004 32 748 755 15308326
  48. [52]Peng Y Latchman Y Elkon KB Ly6c(low) monocytes differentiate into dendritic cells and cross-tolerize t cells through pdl-1 J Immunol 2009 182 2777 2785 19234172 PMC2704574
  49. [53]Allan DS Colonna M Lanier LL Churakova TD Abrams JS Ellis SA McMichael AJ Braud VM Tetrameric complexes of human histocompatibility leukocyte antigen (hla)-g bind to peripheral blood myelomonocytic cells J Exp Med 1999 189 1149 1156 10190906 PMC2193000
  50. [54]Schmidl C Renner K Peter K Transcription and enhancer profiling in human monocyte subsets Blood 2014 123 e90 99 24671955
  51. [55]Anbazhagan K Duroux-Richard I Jorgensen C Apparailly F Transcriptomic network support distinct roles of classical and non-classical monocytes in human Int Rev Immunol 2014 33 470 489 24730730
  52. [56]Wong KL Tai JJ Wong WC Han H Sem X Yeap WH Kourilsky P Wong SC Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets Blood 2011 118 e16 31 21653326
  53. [57]Heinz S Benner C Spann N Bertolino E Lin YC Laslo P Cheng JX Murre C Singh H Glass CK Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and b cell identities Mol Cell 2010 38 576 589 20513432 PMC2898526
  54. [58]Ancuta P Liu KY Misra V Wacleche VS Gosselin A Zhou X Gabuzda D Transcriptional profiling reveals developmental relationship and distinct biological functions of cd16+ and cd16− monocyte subsets BMC Genomics 2009 10 403 19712453 PMC2741492
  55. [59]Haka AS Potteaux S Fraser H Randolph GJ Maxfield FR Quantitative analysis of monocyte subpopulations in murine atherosclerotic plaques by multiphoton microscopy PLoS One 2012 7 e44823 23024767 PMC3443108
  56. [60]Wu H Gower RM Wang H Perrard XY Ma R Bullard DC Burns AR Paul A Smith CW Simon SI Ballantyne CM Functional role of cd11c+ monocytes in atherogenesis associated with hypercholesterolemia Circulation 2009 119 2708 2717 19433759 PMC2716173
  57. [61]Mosig S Rennert K Krause S Kzhyshkowska J Neunübel K Heller R Funke H Different functions of monocyte subsets in familial hypercholesterolemia: Potential function of cd14+ cd16+ monocytes in detoxification of oxidized ldl FASEB J 2009 23 866 874 19001052
  58. [62]Ley K Miller YI Hedrick CC Monocyte and macrophage dynamics during atherogenesis Arterioscler Thromb Vasc Biol 2011 31 1506 1516 21677293 PMC3133596
  59. [63]Robbins CS Hilgendorf I Weber GF Local proliferation dominates lesional macrophage accumulation in atherosclerosis Nat Med 2013 19 1166 1172 23933982 PMC3769444
  60. [64]Hamers AA Vos M Rassam F Marinković G Marincovic G Kurakula K van Gorp PJ de Winther MP Gijbels MJ de Waard V de Vries CJ Bone marrow-specific deficiency of nuclear receptor nur77 enhances atherosclerosis Circ Res 2012 110 428 438 22194623
  61. [65]Hu YW Zhang P Yang JY Huang JL Ma X Li SF Zhao JY Hu YR Wang YC Gao JJ Sha YH Zheng L Wang Q Nur77 decreases atherosclerosis progression in apoe(−/−) mice fed a high-fat/high-cholesterol diet PLoS One 2014 9 e87313 24498071 PMC3909091
  62. [66]Chao LC Soto E Hong C Ito A Pei L Chawla A Conneely OM Tangirala RK Evans RM Tontonoz P Bone marrow nr4a expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice J Lipid Res 2013 54 806 815 23288947 PMC3617954
  63. [67]Saijo K Winner B Carson CT Collier JG Boyer L Rosenfeld MG Gage FH Glass CK A nurr1/corest pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death Cell 2009 137 47 59 19345186 PMC2754279
  64. [68]Huang Y Yin H Wang J Ma X Zhang Y Chen K The significant increase of fcγriiia (cd16), a sensitive marker, in patients with coronary heart disease Gene 2012 504 284 287 22613847
  65. [69]Kashiwagi M Imanishi T Tsujioka H Ikejima H Kuroi A Ozaki Y Ishibashi K Komukai K Tanimoto T Ino Y Kitabata H Hirata K Akasaka T Association of monocyte subsets with vulnerability characteristics of coronary plaques as assessed by 64-slice multidetector computed tomography in patients with stable angina pectoris Atherosclerosis 2010 212 171 176 20684824
  66. [70]Imanishi T Ikejima H Tsujioka H Kuroi A Ishibashi K Komukai K Tanimoto T Ino Y Takeshita T Akasaka T Association of monocyte subset counts with coronary fibrous cap thickness in patients with unstable angina pectoris Atherosclerosis 2010 212 628 635 20615506
  67. [71]Rogacev KS Cremers B Zawada AM Seiler S Binder N Ege P Große-Dunker G Heisel I Hornof F Jeken J Rebling NM Ulrich C Scheller B Böhm M Fliser D Heine GH Cd14++cd16+ monocytes independently predict cardiovascular events: A cohort study of 951 patients referred for elective coronary angiography J Am Coll Cardiol 2012 60 1512 1520 22999728
  68. [72]Rothe G Gabriel H Kovacs E Klucken J Stöhr J Kindermann W Schmitz G Peripheral blood mononuclear phagocyte subpopulations as cellular markers in hypercholesterolemia Arterioscler Thromb Vasc Biol 1996 16 1437 1447 8977447
  69. [73]Krychtiuk KA Kastl SP Pfaffenberger S Pongratz T Hofbauer SL Wonnerth A Katsaros KM Goliasch G Gaspar L Huber K Maurer G Dostal E Oravec S Wojta J Speidl WS Small high-density lipoprotein is associated with monocyte subsets in stable coronary artery disease Atherosclerosis 2014 237 589 596 25463093 PMC4270455
  70. [74]Nahrendorf M Swirski FK Aikawa E Stangenberg L Wurdinger T Figueiredo JL Libby P Weissleder R Pittet MJ The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions J Exp Med 2007 204 3037 3047 18025128 PMC2118517
  71. [75]Ryu JC Davidson BP Xie A Qi Y Zha D Belcik JT Caplan ES Woda JM Hedrick CC Hanna RN Lehman N Zhao Y Ting A Lindner JR Molecular imaging of the paracrine proangiogenic effects of progenitor cell therapy in limb ischemia Circulation 2013 127 710 719 23307829 PMC3573704
  72. [76]Milch HS Schubert SY Hammond S Spiegel JH Enhancement of ischemic wound healing by inducement of local angiogenesis Laryngoscope 2010 120 1744 1748 20623792
  73. [77]Tsujioka H Imanishi T Ikejima H Impact of heterogeneity of human peripheral blood monocyte subsets on myocardial salvage in patients with primary acute myocardial infarction J Am Coll Cardiol 2009 54 130 138 19573729
  74. [78]Frantz S Hofmann U Fraccarollo D Monocytes/macrophages prevent healing defects and left ventricular thrombus formation after myocardial infarction FASEB J 2013 27 871 881 23159933
  75. [79]Hilgendorf I Gerhardt L Tan TC Winter C Holderried TA Chousterman BG Iwamoto Y Liao R Zirlik A Scherrer-Crosbie M Hedrick CC Libby P Nahrendorf M Weissleder R Swirski FK Ly-6Chigh monocytes depend on nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium Circ Res 2014 183 6733 43 PMC4017349 24625784
  76. [80]Lämmermann T Afonso PV Angermann BR Wang JM Kastenmüller W Parent CA Germain RN Neutrophil swarms require ltb4 and integrins at sites of cell death in vivo Nature 2013 498 371 375 23708969 PMC3879961
  77. [81]Michaud JP Pimentel-Coelho PM Tremblay Y Rivest S The impact of ly6clow monocytes after cerebral hypoxia-ischemia in adult mice J Cereb Blood Flow Metab 2014 34 e1 9 24780898 PMC4083393
  78. [83]Bellavance MA Gosselin D Yong VW Stys PK Rivest S Patrolling monocytes play a critical role in cx3cr1-mediated neuroprotection during excitotoxicity Brain Struct Funct 2014 Epub ahead of print 24706067
  79. [84]Shechter R Miller O Yovel G Rosenzweig N London A Ruckh J Kim KW Klein E Kalchenko V Bendel P Lira SA Jung S Schwartz M Recruitment of beneficial m2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus Immunity 2013 38 555 569 23477737 PMC4115271
  80. [85]Devi S Li A Westhorpe CL Lo CY Abeynaike LD Snelgrove SL Hall P Ooi JD Sobey CG Kitching AR Hickey MJ Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus Nat Med 2013 19 107 112 23242472
  81. [86]Lin SL Castaño AP Nowlin BT Lupher ML Duffield JS Bone marrow ly6chigh monocytes are selectively recruited to injured kidney and differentiate into functionally distinct populations J Immunol 2009 183 6733 6743 19864592
  82. [87]Yoshimoto S Nakatani K Iwano M Asai O Samejima K Sakan H Terada M Harada K Akai Y Shiiki H Nose M Saito Y Elevated levels of fractalkine expression and accumulation of cd16+ monocytes in glomeruli of active lupus nephritis Am J Kidney Dis 2007 50 47 58 17591524
  83. [88]Barrat FJ Meeker T Chan JH Guiducci C Coffman RL Treatment of lupus-prone mice with a dual inhibitor of tlr7 and tlr9 leads to reduction of autoantibody production and amelioration of disease symptoms Eur J Immunol 2007 37 3582 3586 18034431
  84. [89]Deane JA Pisitkun P Barrett RS Feigenbaum L Town T Ward JM Flavell RA Bolland S Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation Immunity 2007 27 801 810 17997333 PMC2706502
  85. [90]Vollmer J Tluk S Schmitz C Hamm S Jurk M Forsbach A Akira S Kelly KM Reeves WH Bauer S Krieg AM Immune stimulation mediated by autoantigen binding sites within small nuclear rnas involves toll-like receptors 7 and 8 J Exp Med 2005 202 1575 1585 16330816 PMC2213330
  86. [91]Santiago-Raber ML Dunand-Sauthier I Wu T Li QZ Uematsu S Akira S Reith W Mohan C Kotzin BL Izui S Critical role of tlr7 in the acceleration of systemic lupus erythematosus in tlr9-deficient mice J Autoimmun 2010 34 339 348 19944565
  87. [92]Misharin AV Cuda CM Saber R Turner JD Gierut AK Haines GK Berdnikovs S Filer A Clark AR Buckley CD Mutlu GM Budinger GR Perlman H Nonclassical ly6c(−) monocytes drive the development of inflammatory arthritis in mice Cell Rep 2014 9 591 604 25373902 PMC4223808
  88. [93]Cairns AP Crockard AD Bell AL The cd14+ cd16+ monocyte subset in rheumatoid arthritis and systemic lupus erythematosus Rheumatol Int 2002 21 189 192 11958435
  89. [94]Kawanaka N Yamamura M Aita T Morita Y Okamoto A Kawashima M Iwahashi M Ueno A Ohmoto Y Makino H Cd14+, cd16+ blood monocytes and joint inflammation in rheumatoid arthritis Arthritis Rheum 2002 46 2578 2586 12384915
  90. [95]Fingerle-Rowson G Angstwurm M Andreesen R Ziegler-Heitbrock HW Selective depletion of cd14+ cd16+ monocytes by glucocorticoid therapy Clin Exp Immunol 1998 112 501 506 9649222 PMC1904988
  91. [96]Dayyani F Belge KU Frankenberger M Mack M Berki T Ziegler-Heitbrock L Mechanism of glucocorticoid-induced depletion of human cd14+cd16+ monocytes J Leukoc Biol 2003 74 33 39 12832440

Authors
Thomas, G., Tacke, R., Hedrick, C. C., & Hanna, R. N.
Affiliations
La Jolla Institute for Immunology (US)
Corresponding author
Hanna, Richard N.
ORCID
Venue
Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2015-06
Volume
35
Issue
6
Pages
1306-1316
ISSN
  • 1079-5642 (ISSN-L)
  • 1524-4636
DOI
10.1161/atvbaha.114.304650
PMC
PMC4441550
OpenAlex
W2127385800
Cited by
367
References
98
Citations by year
2026: 31 · 2025: 35 · 2024: 32 · 2023: 33 · 2022: 40 · 2021: 43 · 2020: 29 · 2019: 31 · 2018: 26 · 2017: 38 · 2016: 25 · 2015: 4
FWCI
15.29
Type
journal article
Language
en
Open access
Locations
  • Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (R01HL118765, P01HL055798)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
non-classical monocytes, CX3CR1, Ly6C, CD14, CD16, CCR2, classical monocytes, vascular endothelium, inflammation, wound healing, inflammation resolution, monocyte subsets
MeSH terms
Animals, Arthritis, Cardiovascular Diseases, Cell Adhesion, Cell Differentiation, Cell Survival, Endothelium, Vascular, Humans, Inflammation, Kidney Diseases, Lupus Erythematosus, Systemic, Monocytes, Nervous System Diseases, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review