NLRP3 Inflammasome Inhibition by MCC950 Reduces Atherosclerotic Lesion Development in Apolipoprotein E–Deficient Mice—Brief Report

van der Heijden, Thomas, Kritikou, Eva, Venema, Wouter, van Duijn, Janine, van Santbrink, Peter J., Slütter, Bram, Foks, Amanda C., Bot, Ilze, Kuiper, Johan·2017·Arteriosclerosis, Thrombosis, and Vascular Biology

Cited by (348)

Items 201–300 of 348

  1. Cytotoxin‐associated gene A (CagA) promotes aortic endothelial inflammation and accelerates atherosclerosis through the NLRP3/caspase‐1/IL‐1β axis
    Bowei Li, Yu Liu, Lei Zhang, Xiaoqing Guo, Cheng Wen, Feng Zhang, Xueying Luo, Yuanpeng Xia · 2021 · The FASEB Journal
  2. Targeting autophagy regulation in NLRP3 inflammasome-mediated lung inflammation in COVID-19
    Yuan-Yuan Yong, Li Zhang, Yu-Jiao Hu, Jianming Wu, Lu Yan, Yi‐Ru Pan, Yong Tang, Lu Yu, Betty Yuen Kwan Law, Chong‐Lin Yu et al. · 2022 · Clinical Immunology
  3. Inflammasomes in Atherosclerosis—From Pathophysiology to Treatment
    Panagiotis Theofilis, Evangelos K. Oikonomou, Christos Chasikidis, Konstantinos P Tsioufis, Dimitris Tousoulis · 2023 · Pharmaceuticals
  4. NLRP3 Inflammasome in Inflammation and Metabolism: Identifying Novel Roles in Postburn Adipose Dysfunction
    Roohi Vinaik, Dalia Barayan, Marc G. Jeschke · 2020 · Endocrinology
  5. Aging Leukocytes and the Inflammatory Microenvironment of the Adipose Tissue
    Korbyn J.V. Dahlquist, Christina D. Camell · 2021 · Diabetes
  6. Translating atherosclerosis research from bench to bedside: navigating the barriers for effective preclinical drug discovery
    Lauren Therese May, Belinda A. Di Bartolo, David Glenn Harrison, Tomasz Jan Guzik, Grant Raymond Drummond, Gemma A. Figtree, Rebecca Helen Ritchie, Kerry‐Anne Rye, Judy B. de Haan · 2022 · Clinical Science
  7. Palmitic acid activates NLRP3 inflammasome through NF-κB and AMPK-mitophagy-ROS pathways to induce IL-1β production in large yellow croaker (Larimichthys crocea)
    Xueshan Li, Kangsen Mai, Qinghui Ai · 2023 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  8. Sterile inflammation in the pathogenesis of maturation failure of arteriovenous fistula
    Megan Nguyen, Finosh Gnanaprakasam Thankam, Devendra K. Agrawal · 2021 · Journal of Molecular Medicine
  9. Anti-inflammatory and Immunomodulatory Therapies in Atherosclerosis
    Justine Deroissart, Florentina Porsch, Thomas Köller, Christoph J. Binder · 2021 · Handbook of experimental pharmacology
  10. Insights into the Role of Inflammation in the Management of Atherosclerosis
    Viviane Zorzanelli Rocha, Fabiana Hanna Rached, Marcio Hiroshi Miname · 2023 · Journal of Inflammation Research
  11. Nanoparticle-mediated co-delivery of inflammasome inhibitors provides protection against sepsis
    Dipika Nandi, Maharshi Debnath, James Forster, Ankit Pandey, Hariharan Bharadwaj, Ruchi Kshatri Patel, Ashish A. Kulkarni · 2024 · Nanoscale
  12. Reporting Sex and Sex Differences in Preclinical Studies
    Hong S. Lu, Ann Marie Schmidt, Robert Alexander Hegele, Nigel Mackman, Daniel James Rader, Christian Weber, Alan Daugherty · 2018 · Arteriosclerosis Thrombosis and Vascular Biology
  13. Updates on Approaches for Studying Atherosclerosis
    Congqing Wu, Alan Daugherty, Hong S. Lu · 2019 · Arteriosclerosis Thrombosis and Vascular Biology
  14. Formation and Cellular Impact of Cholesterol Crystals in Health and Disease
    Yvonne Baumer, Sara McCurdy, William A. Boisvert · 2021 · Advanced Biology
  15. Frontiers and hotspots evolution in anti-inflammatory studies for coronary heart disease: A bibliometric analysis of 1990–2022
    Jiale Zhang, Chenyang Ji, Xu Zhai, Hongxuan Tong, Jingqing Hu · 2023 · Frontiers in Cardiovascular Medicine
  16. Inflammasomes: a preclinical assessment of targeting in atherosclerosis
    Jeremiah Stitham, Astrid Rodríguez-Vélez, Xiangyu Zhang, Se‐Jin Jeong, Babak Razani · 2020 · Expert Opinion on Therapeutic Targets
  17. Tanshinone IIA ameliorates myocardial ischemia/reperfusion injury in rats by regulation of NLRP3 inflammasome activation and Th17 cells differentiation
    Dan Li, Zhihui Yang, Shan Gao, Hao Zhang, Guanwei Fan · 2022 · Acta Cirúrgica Brasileira
  18. NLRP3 inflammasome pathway in atherosclerosis: Focusing on the therapeutic potential of non-coding RNAs
    Sulieman Ibraheem Shelash Al-Hawary, Saade Abdalkareem Jasim, Rosario Mireya Romero‐Parra, Ghadeer Sabah Bustani, Ahmed M. Hjazi, Mohammed Alghamdi, Ali Kamil Kareem, Enas R. Alwaily, Rahman Sahib Zabibah, Jitendra Gupta et al. · 2023 · Pathology - Research and Practice
  19. Unleashing the biomimetic targeting potential of platelet-derived nanocarriers on atherosclerosis
    Nasrullah Jan, Mohammad F. Bostanudin, Sedq A. Moutraji, Sedra Kremesh, Zul Kamal, Muhammad Farhan Hanif · 2024 · Colloids and Surfaces B Biointerfaces
  20. Nucleotide‐Binding Oligomerization Domain‐Like Receptor Protein 3 Deficiency in Vascular Smooth Muscle Cells Prevents Arteriovenous Fistula Failure Despite Chronic Kidney Disease
    Xiangchao Ding, Jiuling Chen, Chuangyan Wu, Guohua Wang, Cheng Zhou, Shanshan Chen, Ke Wang, Anchen Zhang, Ping Ye, Jie Wu et al. · 2018 · Journal of the American Heart Association
  21. Nonalcoholic Fatty Liver Disease.
    Ling-Ling Ding, Y. Oligschlaeger, R. Shiri-Sverdlov, T. Houben · 2020 · Handbook of Experimental Pharmacology
  22. NLRP3 Inflammasome in Vascular Disease: A Recurrent Villain to Combat Pharmacologically
    Ainara González‐Moro, Inés Valencia, Licia Shamoon, Carlos F. Sánchez‐Ferrer, Concepción Peiró, Fernando de la Cuesta · 2022 · Antioxidants
  23. USP22 enhances atherosclerotic plaque stability and macrophage efferocytosis by stabilizing PPARγ
    Senhu Tang, Chuanghong Lu, Zhongyuan Meng, Zihua Ye, Yue Qin, Na Na, Shenglin Xian, Feng Huang, Zhiyu Zeng · 2025 · Communications Biology
  24. Connexin 43: A Target for the Treatment of Inflammation in Secondary Complications of the Kidney and Eye in Diabetes
    Chelsy L. Cliff, Bethany M. Williams, Christos Evangelos Chadjichristos, Ulrik Mouritzen, Paul Edward Squires, Claire Elizabeth Hills · 2022 · International Journal of Molecular Sciences
  25. NLRP3 ‐directed antisense oligonucleotides reduce microglial immunoactivities in vitro
    Charlotte Braatz, Max P. Komes, Kishore Aravind Ravichandran, Matheus Garcia de Fragas, Angelika Griep, Stephanie Schwartz, Róisín M. McManus, Michael Thomas Heneka · 2023 · Journal of Neurochemistry
  26. Igniting hope: Harnessing NLRP3 inflammasome-GSDMD-mediated pyroptosis for cancer immunotherapy
    Lingrui Li, Lei Chen, Zhi‐Jun Sun · 2024 · Life Sciences
  27. Aquilariae Lignum Methylene Chloride Fraction Attenuates IL-1β-Driven Neuroinflammation in BV2 Microglial Cells
    Jin‐Seok Lee, Yoo-Jin Jeon, Ji-Yun Kang, Sam-Keun Lee, Hwa-Dong Lee, Chang‐Gue Son · 2020 · International Journal of Molecular Sciences
  28. Therapeutic Implications of NLRP3-Mediated Inflammation in Coronary Artery Disease
    Gregory Hemenway, William H. Frishman · 2021 · Cardiology in Review
  29. The cytoplasmic sensor, the AIM2 inflammasome: A precise therapeutic target in vascular and metabolic diseases
    Jiuguo Lin, Jiaojiao Wang, Jian Fang, Meihang Li, Suowen Xu, Peter J. Little, Dongmei Zhang, Zhiping Liu · 2024 · British Journal of Pharmacology
  30. Maternal high-fat diet exaggerates diet-induced insulin resistance in adult offspring by enhancing inflammasome activation through noncanonical pathway of caspase-11
    Naotoshi Wada, Hiroyuki Yamada, Shinichiro Motoyama, Makoto Saburi, Takeshi Sugimoto, Hiroshi Kubota, Daisuke Miyawaki, Noriyuki Wakana, Daisuke Kami, Takehiro Ogata et al. · 2020 · Molecular Metabolism
  31. Fatal attractions that trigger inflammation and drive atherosclerotic disease
    Hitesh Sharma, Karen Louise Mossman, Richard C. Austin · 2024 · European Journal of Clinical Investigation
  32. 18F-FDG PET imaging-monitored anti-inflammatory therapy for acute myocardial infarction: Exploring the role of MCC950 in murine model
    Xiang Li, Weidong Yang, Wenhui Ma, Xiang Zhou, Zhiyong Quan, Guoquan Li, Daliang Liu, Qingju Zhang, Dong Hoon Han, Beilei Gao et al. · 2020 · Journal of Nuclear Cardiology
  33. Targeting the NLRP3 inflammasome in sepsis: Molecular mechanisms and therapeutic strategies
    Yuhui Ma, Jialei Meng, Fangyuan Sun, Ming Lei · 2025 · Cytokine & Growth Factor Reviews
  34. Nuclear Receptors and Clock Components in Cardiovascular Diseases
    Benoît Pourcet, Hélène Duez · 2021 · International Journal of Molecular Sciences
  35. Colchicine ameliorates short-term abdominal aortic aneurysms by inhibiting the expression of NLRP3 inflammasome components in mice
    Jiaxin Hu, Jiamin Xu, Jiling Zhao, Yuwei Liu, Rui Huang, Dejiang Yao, Jun Xie, Yuhua Lei · 2023 · European Journal of Pharmacology
  36. Potential Therapeutic Value of Interleukin 1b-targeted Strategies in Atherosclerotic Cardiovascular Disease
    Vanesa Viana‐Huete, José J. Fuster · 2019 · Revista Española de Cardiología (English Edition)
  37. Global research trends in atherosclerosis: A bibliometric and visualized study
    Wende Tian, Tai Zhang, Xinyi Wang, Jie Zhang, Jianqing Ju, Hao Xu · 2022 · Frontiers in Cardiovascular Medicine
  38. Valor terapéutico potencial de las estrategias dirigidas contra la interleucina 1β en la enfermedad cardiovascular ateroesclerótica
    Vanesa Viana‐Huete, José J. Fuster · 2019 · Revista Española de Cardiología
  39. Connecting the Dots: NLRP3 Inflammasome as a Key Mediator in the Intersection of Depression and Cardiovascular Disease – A Narrative Review
    Ghazaleh Ghaffaripour Jahromi, Nima Rezaei · 2025 · Heart and Mind
  40. Platelet-derived biomimetic nanoplatforms: a promising drug delivery strategy for cardiovascular disease
    Simin Zhang, Mei Han, Shan Li, Yixuan Wang, Lihua Wu, Li Dong, Pan Liang · 2025 · Journal of Nanobiotechnology
  41. The importance of mitochondria and mitochondrial calcium signaling in health and disease: an updated outlook on inflammation
    Giampaolo Morciano, Giulia Pellielo, Esther Densu Agyapong, Cristina Pellegrino, Simone Patergnani, Davide Franceschini, Konstantinos Koutsikos, Leonardo Rigon, Paolo Pinton, Alessandro Rimessi · 2026 · Journal of Translational Medicine
  42. Emerging insights into the role of NLRP3 inflammasome and endoplasmic reticulum stress in renal diseases
    Yan-ting Yann Zhang, Shiyun Guo, Xiaodi Fu, Qi Zhang, Honggang Wang · 2024 · International Immunopharmacology
  43. Genetic and epigenetic regulation of inflammasomes: Role in atherosclerosis
    Mustafa Yalçınkaya, Alan R. Tall · 2024 · Atherosclerosis
  44. NLRP3 as a sensor of metabolism gone awry
    Emilia Neuwirt, Oliver Gorka, Benedikt S. Saller, Christina J. Groß, Tobias Madl, Olaf Groß · 2021 · Current Opinion in Biotechnology
  45. NLRP3 Inflammasome Inhibition by the Novel Bispecific Antibody InflamAb Attenuates Atherosclerosis in Apolipoprotein E–Deficient Mice
    Lucie Delfos, Marie A.C. Depuydt, Melody Chemaly, Sophie Coyle, Frank H. Schaftenaar, Peter J. van Santbrink, Pier Pieterszoon Lindenbergh, Mireia N. A. Bernabé Kleijn, Ciara Costello, Christopher Power et al. · 2025 · JACC Basic to Translational Science
  46. NLRP3 Inflammasome: A New Target for the Treatment of CVD and Depression Comorbidity
    Chen Chen, Siqi Zhang, Ming Sheng, Wei Shao · 2025 · Mediators of Inflammation
  47. Optimal Medical Therapy Targeting Lipids and Inflammation for Secondary Prevention in Patients Undergoing Percutaneous Coronary Intervention
    Imma Forzano, Domenico Florimonte, Viviana Narciso, Mario Enrico Canonico, Domenico Simone Castiello, Lina Manzi, Stefano Cristiano, Alessandra Maria Spinelli, Donato Maria Vallone, Dario D’Alconzo et al. · 2025 · Journal of Clinical Medicine
  48. Inhibition of NLRP3 inflammasome activity by MCC950 leads to exacerbation of Sjӧgren's syndrome pathologies in non‐obese diabetic mice
    Jing Zhou, Shoko Onodera, Qing Yu · 2022 · Immunology
  49. Molecular Mechanism of NLRP3 Inflammasome in Inflammatory Diseases and Tumors
    Le‐Lan Gong, Hejiang Zhou, Quanming Zhao, Ning Xu, Feng‐Chang Huang, Ling‐Yan Su, Wenliang Li · 2025 · Immunity Inflammation and Disease
  50. Crosstalk Between Cholesterol, ABC Transporters, and PIP2 in Inflammation and Atherosclerosis
    Kailash Gulshan · 2023 · Advances in experimental medicine and biology
  51. Inflammasomes and Cardiovascular Disease: Linking Inflammation to Cardiovascular Pathophysiology
    Mohamed J. Saadh, Faris Anad Muhammad, Rafid Jihad Albadr, Gaurav V. Sanghvi, S. Renuka Jyothi, Mayank Kundlas, Kamal Kant Joshi, Anvar Rakhmatullaev, Waam Mohammed Taher, Mariem Alwan et al. · 2025 · Scandinavian Journal of Immunology
  52. Liver kinase B1 attenuates liver ischemia/reperfusion injury via inhibiting the NLRP3 inflammasome
    Jiangwen Dai, Qingsong Chen, Wei-Feng Huang, Kun Shi, Yuke Zhang, Tingting Li, Tong Mou, Zuotian Huang, Zhongjun Wu · 2021 · Acta Biochimica et Biophysica Sinica
  53. NLRP3 priming due to skin damage precedes LTP allergic sensitization in a mouse model
    Diego Pazos‐Castro, Zulema Gonzalez Klein, Alma Yuste‐Montalvo, Guadalupe Hernández‐Ramírez, Alejandro Romero‐Sahagun, Vanesa Esteban, María Garrido‐Arandia, Jaime Tomé‐Amat, Araceli Díaz‐Perales · 2022 · Scientific Reports
  54. The NLRP3 Inflammasome Works as a Sensor for Detecting Hypoactivity of the Mitochondrial Src Family Kinases
    Yuto Sekiguchi, Saya Takano, Takuya Noguchi, Tomohiro Kagi, Ryuto Komatsu, Maoko Tan, Yusuke Hirata, Atsushi Matsuzawa · 2023 · The Journal of Immunology
  55. MCC950 ameliorates cognitive function by reducing white matter microstructure damage in rats after SAH
    Yunchuan Cao, Yingwen Wang, Xiaoguo Li, Xiaomin Yang, Bo Zeng, Zongduo Guo · 2023 · Brain Research Bulletin
  56. Targeting the NLRP3 Inflammasome-Gasdermin D Axis to Combat Cardiovascular Diseases
    Judy S.Y. Choi, Mehnaz Pervin, James Edward Vince, Arpeeta Sharma, Judy B. de Haan · 2025 · Journal of Molecular and Cellular Cardiology
  57. The Severity of CVB3‐Induced Myocarditis Can Be Improved by Blocking the Orchestration of NLRP3 and Th17 in Balb/c Mice
    Jifei Chen, Fan Yang, Song Shi, Xuexiang Liu, Fengxian Qin, Xiaomou Wei, Yujie Huang, Wenwu Liang, Lin Miao · 2021 · Mediators of Inflammation
  58. MCC950 attenuates inflammation-mediated damage in canines with Staphylococcus pseudintermedius keratitis by inhibiting the NLRP3 inflammasome
    Long Guo, Zhihao Wang, Jun Li, Luying Cui, Junsheng Dong, Xia Meng, Guoqiang Zhu, Jianji Li, Heng Wang · 2022 · International Immunopharmacology
  59. GP73 enhances the ox-LDL-induced inflammatory response in THP-1 derived macrophages via affecting NLRP3 inflammasome signaling
    Yi-fen Lin, M. Li, Rihua Huang, Shaozhao Zhang, Xingfeng Xu, Huimin Zhou, Menghui Liu, Xinxue Liao, Lizhen Liao, Yue Guo et al. · 2023 · International Journal of Cardiology
  60. OxLDL induces the release of IL-1β from primed human endothelial and smooth muscle cells via different caspase -1-dependent mechanisms
    Majid Almansouri, Pooja Patel, Janet Chamberlain, Sheila Francis · 2022 · Vascular Biology
  61. Integrated Stress Response Inhibition in Atherosclerosis
    José J. Fuster · 2019 · Journal of the American College of Cardiology
  62. Macrophages in human atherosclerotic plaques in the era of single-cell and spatial transcriptomics
    Adil Ijaz, Adil Rasheed, Marco Orecchioni · 2026 · ImmunoHorizons
  63. Synthesis and Evaluation of [11C]MCC950 for Imaging NLRP3-Mediated Inflammation in Atherosclerosis
    Uzair S. Ismailani, Ariel Buchler, Nicole MacMullin, Faduma Abdirahman, Myriam Adi, Benjamin H. Rotstein · 2023 · Molecular Pharmaceutics
  64. The regulation of self-tolerance and the role of inflammasome molecules
    Ke Qi, Ashley Nicole Greenawalt, Veera Manukonda, Xingqi Ji, Roland Tisch · 2023 · Frontiers in Immunology
  65. Exploring the Role of NLRP3 in Neurodegeneration: Cutting‐Edge Therapeutic Strategies and Inhibitors
    Mohammed Ahmed Mustafa, Pooja Bansal, MS Pallavi, Rajashree Panigrahi, Deepak Nathiya, Sachin Kumar, Shaker Al-Hasnaawei, Ashish Singh Chauhan, Siya Singla · 2025 · Developmental Neurobiology
  66. Inflammasomes: Role in Disease Pathogenesis and Therapeutic Potential
    Ekaterina Evgenevna Garanina, Ekaterina Vladimirovna Martynova, Konstantin Ivanov, Albert Anatolyevich Rizvanov, Svetlana Francevna Khaiboullina · 2020 · Učënye zapiski Kazanskogo universiteta. Seriâ Estestvennye nauki/Učënye zapiski Kazanskogo universiteta. Seriâ Estestvennye nauki/Učenye zapiski Kazanskogo gosudarstvennogo universiteta. Seriâ Estestvennye nauki
  67. Identification of anti-inflammatory and anti-cancer compounds targeting the NF-κB-NLRP3 inflammasome pathway from a phytochemical library of the Sideritis genus
    Rümeysa Yücer, Angela Schröder, Gülaçtı Topçu, Thomas Efferth · 2024 · Journal of Ethnopharmacology
  68. MCC950 inhibits the inflammatory response and excessive proliferation of canine corneal stromal cells induced by Staphylococcus pseudintermedius
    Long Guo, Zhihao Wang, Chengcheng Zhu, Jun Li, Luying Cui, Junsheng Dong, Xia Meng, Guoqiang Zhu, Jianji Li, Heng Wang · 2022 · Molecular Immunology
  69. NLRP3 Activation Contributes to Memory Impairment in an Experimental Model of Pneumococcal Meningitis
    Jaqueline S. Generoso, Cristiano Julio Faller, Allan Collodel, Carlos Henrique Rocha Catalão, Diogo Dominguini, Fabricia Cardoso Petronilho, Tatiana Barichello, Vijayasree Vayalanellore Giridharan · 2023 · Molecular Neurobiology
  70. Research Landscape on Atherosclerotic Cardiovascular Disease and Inflammation: A Bibliometric and Visualized Study
    Wende Tian, Tai Zhang, Xinyi Wang, Jie Zhang, Jianqing Ju, Hao Xu · 2022 · Reviews in Cardiovascular Medicine
  71. Endothelial dysfunction in atherosclerosis: from classical pathways to emerging mechanisms
    Yuyao Feng, Chenyang Li, Junye Chen, Xingqi Xiao, Qi Mao, Hongmei Zhao, Jing Wang, Bao Liu · 2025 · Vessel Plus
  72. Natural, Engineered, and Hybrid Platelet Membrane–Based Nanotherapeutics for Inflammatory Diseases
    Boyuan Liu, Yongjie Wang, Weiquan Gong, Song Han, Zhenshan Lv, Zilin Zhang, Jinwei Qi, Aijun Song, Zongyuan Yang, Longfei Duan et al. · 2025 · International Journal of Nanomedicine
  73. Inflammasome Targeted Therapy as Novel Treatment Option for Aortic Aneurysms and Dissections: A Systematic Review of the Preclinical Evidence
    Markus Wortmann, Rosa Klotz, Eva Kalkum, Susanne Dihlmann, Dittmar Böckler, Andreas Sebastian Peters · 2022 · Frontiers in Cardiovascular Medicine
  74. Blockage of the NLRP3 inflammasome by MCC950 inhibits migration and invasion in adenomyosis
    Yanping Liu, Zhou Jiang, Lu Zhang, Wei Tian, Aimin Lin, Mingjiang Li · 2024 · Reproductive BioMedicine Online
  75. Immune-mediated interactions between sarcopenia and atherosclerosis in aging
    Mei Yu, Rujia Zhao, Li-Chao Ge, Tong Yu, Hangyan Shen, Chengyi Dai, Haihua Wang · 2025 · Immunity & Ageing
  76. Target practice: Opportunities for therapeutic intervention in CHIP and CCUS
    Ayman Mohammad, John O Mascarenhas, Bridget Kelly Marcellino, Daniel I. Nathan · 2025 · Blood Reviews
  77. LncRNA MIR17HG accelerates the development of atherosclerosis by promoting macrophage pyroptosis through the miR-301a-3p/TXNIP pathway
    Yu-Ping Wang, Xian Liu, Xiaodan Xu, Lei Hui, Guanghong Xu, Mengqing Ma, Lin Zhu, Kun Ren · 2025 · International Immunopharmacology
  78. Global research trends of Apolipoprotein E in central nervous system: A scientometric analysis
    Kai Gong, Yuhua Chen, Wei Liu, Zhanxiang Wang · 2021 · International Immunopharmacology
  79. Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment
    Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Po Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng et al. · 2026 · Med Research
  80. Dehydroepiandrosterone inhibits vascular proliferation and inflammation by modulating the miR-486a-3p/NLRP3 axis.
    Manli Zhang, Manna Zhang, Wenli Wang, Hui Chen, Xia Wang, Kun Zhao, Ze Li, Jiangqing Xu, Fei Tong · 2022 · PubMed Central
  81. Pyroptosis: the dawn of a new era in endometrial cancer treatment
    Peng Tian, Chi Zhang, Wenjun Chen, Xuefei Zhao, Weibo Wu, Weiji Yang, Ruojia Liang · 2023 · Frontiers in Oncology
  82. Age-associated diseases: the role of the inflammasome complex
    Ludmila V. Gankovskaya, O.V. Artemyeva, Греченко Вячеслав Владимирович, Насаева Екатерина Дмитриевна, Е. М. Хасанова · 2023 · Immunologiya
  83. Spotlight on macrophage pyroptosis: A bibliometric and visual analysis from 2001 to 2023
    Zhimei Peng, Hua Xiao, Yao Tan, Xinzhou Zhang · 2024 · Heliyon
  84. Stem cell-derived exosomes prevent the development of thoracic aortic aneurysm/dissection by inhibiting AIM2 inflammasome and pyroptosis
    Lin Lu, Feng Liu, Weiliang Wu, Yu Zhang, Bin Liu, Qingfang Han, Tonggan Lu, Huiling Zhang, Xiyong Yu, Yangxin Li · 2024 · Extracellular Vesicle
  85. PGC1α enhances macrophage efferocytosis in ox-LDL-stimulated RAW264.7 cells by regulating the NLRP3/PPARα axis
    Qi Long Lu, Xujiao Chen, Qijun Zhang · 2024 · Tissue and Cell
  86. Recent Highlights of ATVB
    Jacqueline S. Dron, Julieta Lazarte, Robert Alexander Hegele · 2018 · Arteriosclerosis Thrombosis and Vascular Biology
  87. Inflammasomes as Potential Therapeutic Targets in Atherosclerotic Cardiovascular Disease
    Ping Wang, Jun Ma, Ru Zhang · 2022 · Endocrine Metabolic & Immune Disorders - Drug Targets
  88. Targeting the NLRP3 inflammasome and associated cytokines in scleroderma associated interstitial lung disease
    Samuel Woo, Shifa Gandhi, Alexander Ghincea, Tina Saber, Chris Lee, Changwan Ryu · 2023 · Frontiers in Cell and Developmental Biology
  89. Progression of Multifaceted Immune Cells in Atherosclerotic Development
    Sungmi Park, In‐Kyu Lee · 2019 · Journal of Lipid and Atherosclerosis
  90. Metabolic Inflammation as a Common Thread in Cardio-Endocrine Diseases: Toward a Unified Therapeutic Framework
    Nidhi Patil, Neha Uppal, Simranjeet Bedi, Hiral Undhad, Pooja Joshi · 2026 · Cureus
  91. Immune–endothelial crosstalk in cardiovascular inflammation: Canakinumab at the intersection of mechanism and precision therapy
    Arti Srivastava, Drishya Dinesh, Jagriti Bhatia, Dharmavir Singh Arya · 2026 · Biomedicine & Pharmacotherapy
  92. Inflammasome-Driven Cardiac Fibrosis in Cardiometabolic Disease and Arrhythmias: Mechanisms, Biomarkers, and Therapeutic Targets
    Konstantinos Grigoriou, Vasileios Lamprou, Antonios P. Antoniadis, Panagiotis Theofilis, Panagιotis Iliakis, Nikolaos Ktenopoulos, Anastasiοs Apostolos, Athina Nasoufidou, Barbara Fyntanidou, Efstratios Karagiannidis et al. · 2026 · Frontiers in Bioscience-Landmark
  93. The genetic advantage of healthy centenarians: unraveling the central role of NLRP3 in exceptional healthspan
    Stefan F. F. Verlinden · 2024 · Frontiers in Aging
  94. Discovery of N-phenyl-1-(phenylsulfonamido)cyclopropane-1-carboxamide analogs as NLRP3 inflammasome inhibitors
    Wanwan Li, Zhongqiang Cao, Junjie Cheng, Feiyu Chen, Shuai Li, Yiwei Huang, Long Tai Zheng, Na Ye · 2021 · Medicinal Chemistry Research
  95. Exploring Inflammasome Complex as a Therapeutic Approach in Inflammatory Diseases
    Sharmim Sultana, Thanh Doan Viet, Tasmiha Amin Oishy, Esha Kazi, Luigina Micolucci, A. K. M. Moniruzzaman Mollah, Most Mauluda Akhtar, Md Soriful Islam · 2023 · Future Pharmacology
  96. Bone-marrow mononuclear cells and acellular human amniotic membrane improve global cardiac function without inhibition of the NLRP3 Inflammasome in a rat model of heart failure
    Aline Luri Takejima, Paulo André Bispo Machado Júnior, Gustavo Gavazzoni Blume, Rossana Baggio Simeoni, Júlio César Francisco, Murilo Sgarbossa Tonial, Luis Felipe Marqueze, Lúcia de Noronha, Márcia Olandoski, Eltyeb Abdelwahid et al. · 2024 · Anais da Academia Brasileira de Ciências
  97. Targeting against the activity of the NLRP3 inflammasome is a potential therapy for rat testicular tissue cryopreservation and transplantation
    Juntao Li, Jingjing Liu, Zhao‐Wei Song, Xi‐Lan Lu, Hongxia Wang, Jianmin Zhang · 2021 · Andrologia
  98. Negative regulatory mechanisms of NLRP3 inflammasome
    Wei Zhao, Ying QIN · 2018 · Scientia Sinica Vitae
  99. NLRP3 inflammasome inhibition protects against intracranial aneurysm rupture and alters the phenotype of infiltrating macrophages
    William Dodd, Devan Patel, Kartik Motwani, Brandon Peter Lucke-Wold, Koji Hosaka, Brian Lim Hoh · 2023 · Frontiers in Stroke
  100. A Review: Can Cytokines Induce Vascular Inflammation as a Sequela of Viral Infections?
    Shahana Akhter Deena, Samia Aziz Tonima, Sakif Ahamed Khan, Mohammad Shahangir Biswas, Syed Masudur Rahman Dewan · 2025 · Health Science Reports