The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.
Neutrophil Extracellular Traps: Villains and Targets in Arterial, Venous, and Cancer-Associated Thrombosis
Open accessAbstract
Recent studies have demonstrated a role of neutrophils in both venous and arterial thrombosis. A key prothrombotic feature of neutrophils is their ability to release web-like structures composed of DNA filaments coated with histones and granule proteins referred to as neutrophil extracellular traps (NETs). NETs were discovered over a decade ago as part of our first line of host defense against invading microorganisms. Although NETs have a protective role against pathogens, recent data suggest that an uncontrolled and excessive NET formation within the vasculature may contribute to pathological thrombotic disorders. In vitro studies suggest that NETs promote vessel occlusion by providing a scaffold for platelets, red blood cells, extracellular vesicles, and procoagulant molecules, such as von Willebrand factor and tissue factor. In addition, NET components enhance coagulation by both activating the intrinsic pathway and degrading an inhibitor of the extrinsic pathway (tissue factor pathway inhibitor). NET formation has, therefore, been proposed to contribute to thrombus formation and propagation in arterial, venous, and cancer-associated thrombosis. This review will describe animal and human studies suggesting a role of NETs in the pathogenesis of various thrombotic disorders. Targeting NETs may be a novel approach to reduce thrombosis without affecting hemostasis.
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Cites
Immunity, Inflammation, and Cancer
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Neutrophil Extracellular Traps Kill Bacteria
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Extracellular DNA traps promote thrombosis
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Self-citationThe role of co-infections and secondary infections in patients with COVID-19
Feldman, C., & Anderson, R. (2021) · Pneumonia · doi:10.1186/s41479-021-00083-w · Cited by 319
Neutrophil extracellular traps and thrombosis in COVID-19
Zuo, Y., Zuo, M., Yalavarthi, S., Gockman, K., Madison, J. A., Shi, H., Woodard, W., Lezak, S. P., Lugogo, N. L., Knight, J. S., et al. (2021) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-020-02324-z · Cited by 267
The neurobiology of SARS-CoV-2 infection
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Metadata
- Authors
- Thålin, C., Hisada, Y., Lundström, S., Mackman, N., & Wallén, H.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2019-09
- Volume
- 39
- Issue
- 9
- Pages
- 1724-1738
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2963080746
- Cited by
- 406
- References
- 132
- FWCI
- 15.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Thålin, C., Hisada, Y., Lundström, S., Mackman, N., & Wallén, H. (2019). Neutrophil Extracellular Traps: Villains and Targets in Arterial, Venous, and Cancer-Associated Thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/atvbaha.119.312463
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