Inhibition of VEGF (Vascular Endothelial Growth Factor)-A or its Receptor Activity Suppresses Experimental Aneurysm Progression in the Aortic Elastase Infusion Model

Xu, Baohui; Iida, Yasunori; Glover, Keith J.; Ge, Yingbin; Wang, Yan; Xuan, Haojun; Hu, Xiaolei; Tanaka, Hiroki; Wang, Wei; Fujimura, Naoki; Miyata, Masaaki; Shoji, Takahiro; Guo, Jia; Zheng, Xiaoya; Gerritsen, Mary; Kuo, Calvin; Michie, Sara A.; Dalman, Ronald L.

doi:10.1161/atvbaha.119.312497

Inhibition of VEGF (Vascular Endothelial Growth Factor)-A or its Receptor Activity Suppresses Experimental Aneurysm Progression in the Aortic Elastase Infusion Model

Objective: We examined the pathogenic significance of VEGF (vascular endothelial growth factor)-A in experimental abdominal aortic aneurysms (AAAs) and the translational value of pharmacological VEGF-A or its receptor inhibition in aneurysm suppression. Approaches and Results: AAAs were created …