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Cited by 242Erythrocyte Function and PathophysiologyIon Channels and ReceptorsCellular Mechanics and Interactions

Force Sensing by Piezo Channels in Cardiovascular Health and Disease

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Beech, David J., Kalli, Antreas C.·2019·Arteriosclerosis, Thrombosis, and Vascular Biology
DOI 10.1161/atvbaha.119.313348PMC PMC6818984
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Abstract

Mechanical forces are fundamental in cardiovascular biology, and deciphering the mechanisms by which they act remains a testing frontier in cardiovascular research. Here, we raise awareness of 2 recently discovered proteins, Piezo1 and Piezo2, which assemble as transmembrane triskelions to combine exquisite force sensing with regulated calcium influx. There is emerging evidence for their importance in endothelial shear stress sensing and secretion, NO generation, vascular tone, angiogenesis, atherosclerosis, vascular permeability and remodeling, blood pressure regulation, insulin sensitivity, exercise performance, and baroreceptor reflex, and there are early suggestions of relevance to cardiac fibroblasts and myocytes. Human genetic analysis points to significance in lymphatic disease, anemia, varicose veins, and potentially heart failure, hypertension, aneurysms, and stroke. These channels appear to be versatile force sensors, used creatively to inform various force-sensing situations. We discuss emergent concepts and controversies and suggest that the potential for new important understanding is substantial.

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  • Most endothelial cells express Piezo1 in the mRNA and protein forms.

    “Numerous studies have indicated that most endothelial cells express Piezo1 in the mRNA and protein forms.33,34,82,83,84,85,86”

    From Mechanosensitive calcium ion channels Piezo1: A therapeutic target in liver disease (2025) · cites this paper as [82]

    The “Piezo1 in Endothelium” section describes Piezo1-dependent responses in embryonic and adult endothelial cells, supporting endothelial Piezo1 presence. It does not establish that most endothelial cells express it or specify expression in both mRNA and protein forms; searches for those terms found no such passage. Page numbers are unavailable in our copy. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

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References 113 · Cited by 242

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Authors
Beech, D. J., & Kalli, A. C.
Affiliations
University of Leeds (GB)
Corresponding author
Beech, David J.
ORCID
Venue
Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2019-11
Volume
39
Issue
11
Pages
2228-2239
ISSN
  • 1079-5642 (ISSN-L)
  • 1524-4636
DOI
10.1161/atvbaha.119.313348
PMC
PMC6818984
OpenAlex
W2973598194
Cited by
242
References
113
Citations by year
2026: 25 · 2025: 36 · 2024: 49 · 2023: 36 · 2022: 35 · 2021: 39 · 2020: 20 · 2019: 1 · 2018: 1
FWCI
2.80
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
Funders
  • Wellcome Trust (110044/Z/15/Z)
  • British Heart Foundation (RG/17/11/33042)
  • Academy of Medical Sciences (SBF002\1031)
Topics
  • Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Keywords
Piezo1, Piezo2, mechanosensitive ion channels, mechanotransduction, endothelial shear stress, calcium influx, nitric oxide production, vascular tone, angiogenesis, atherosclerosis, vascular permeability, vascular remodeling, blood pressure regulation, insulin sensitivity, baroreflex, cardiomyocytes, lymphatic disorders, heart failure, hypertension, stroke
MeSH terms
Animals, Cardiovascular Diseases, Cardiovascular Physiological Phenomena, Endothelium, Vascular, Humans, Ion Channels, Mutation, Calcium Channels, Mechanotransduction, Cellular

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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